Q2JQB9 (KGUA_SYNJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	CYA_2697

Organism

Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321327 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266424
Regions
	Domain	30 – 208	179	Guanylate kinase-like
	Nucleotide binding	37 – 44	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JQB9 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 61E2477E160DBA4A	FASTA	217	24,522
	10 20 30 40 50 60 MAVSSTTLSS PTPPECLQQQ EAPRPPATRG RLVVLTGPSG VGKGTLVSQL RQRHPELYFS 70 80 90 100 110 120 VSVTTRPPRP GEQEGVNYYF RTREEFLNLI EADELLEWAQ YAGNFYGTPR EIVFQKLSQG 130 140 150 160 170 180 QDVLLEIELA GARQVRQQCP DAIRIFLSPP SLEELERRIR ERGQDSEASI QRRLQQARKE 190 200 210 LDAKDEFDYV IVNDNLEQAL QELEALLYPP SPGKGQS

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-3-3Ab.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000239 Genomic DNA. Translation: ABD00807.1.
RefSeq	YP_476070.1. NC_007775.1.
3D structure databases
ProteinModelPortal	Q2JQB9.
ModBase	Search...
Protein-protein interaction databases
STRING	321327.CYA_2697.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD00807; ABD00807; CYA_2697.
GeneID	3899459.
KEGG	cya:CYA_2697.
PATRIC	23813656. VBISynSp90045_2653.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037640.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_SYNJA

Accession

Primary (citable) accession number: Q2JQB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program