Q2JPP9 (Q2JPP9_SYNJB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase HAMAP MF_01401

Gene names

Name:	msrA HAMAP MF_01401
Ordered Locus Names:	CYB_0235

Organism

Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321332 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 EMBL ABD01233.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	59	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	Q2JPP9 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: C866A773A9D127CC	FASTA	222	24,888
	10 20 30 40 50 60 MVLFGFGKLG KKLSLPKPEE ALPGRAEPMV IVNRHFVNGH PLQPPFPEGM ELAMFGMGCF 70 80 90 100 110 120 WGAERKFWQV PGVFSTAVGY AGGFTPNPTY EEVCTGLTGH NEVVRVVYDP AQVSYAQLLK 130 140 150 160 170 180 VFWENHDPTQ GMRQGNDVGT QYRSGIYVYS PAQRELAEKT RDLYQQALTA HGYGQITTEI 190 200 210 220 LDAPEFYYAE DYHQQYLAKN PRGYCGLRGT RVCLPEILTE PA

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000240 Genomic DNA. Translation: ABD01233.1.
RefSeq	YP_476496.1. NC_007776.1.
3D structure databases
ProteinModelPortal	Q2JPP9.
SMR	Q2JPP9. Positions 18-215.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JPP9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3900962.
GenomeReviews	Gene locus CYB_0235 in contig CP000240_GR.
KEGG	cyb:CYB_0235.
PATRIC	23802752. VBISynSp29577_0243.
TIGR	CYB_0235.
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	QETSFEQ.
PhylomeDB	Q2JPP9.
ProtClustDB	CLSK750153.
Enzyme and pathway databases
BioCyc	SSP321332:CYB_0235-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2JPP9_SYNJB

Accession

Primary (citable) accession number: Q2JPP9

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)