Q2JPJ7 (COMB_SYNJB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	CYB_0287

Organism

Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321332 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000014470

Sequences

	Sequence		Length	Mass (Da)
	Q2JPJ7 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: AFA132E60C78F3B9	FASTA	242	25,942
	10 20 30 40 50 60 MRFFHFYTPE QVPSSGIPEC AVAIDVLRAT TTIATALAAG AEAVQVFAHL QQLQEASQNW 70 80 90 100 110 120 PASQRLLAGE RGGKAVAGFD LGNSPLDYTP DRVRDKRIFL STTNGTRSLQ RLEGIPVVIT 130 140 150 160 170 180 AALVNLGAVV DFLRRGSFAE VWLVGSGWEG AFSLEDTACA GAILHRLGCS LNQLGNDETL 190 200 210 220 230 240 AALALYQTWQ DDLLGLLRRS SHGQRLLGLG PENDQDLAYC ADLDRLSVVP RQVQPGVLAS GG

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000240 Genomic DNA. Translation: ABD01285.1.
RefSeq	YP_476548.1. NC_007776.1.
3D structure databases
ProteinModelPortal	Q2JPJ7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JPJ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3902192.
GenomeReviews	Gene locus CYB_0287 in contig CP000240_GR.
KEGG	cyb:CYB_0287.
PATRIC	23802854. VBISynSp29577_0294.
TIGR	CYB_0287.
Phylogenomic databases
eggNOG	COG2045.
HOGENOM	HBG633644.
OMA	GWEGAYS.
PhylomeDB	Q2JPJ7.
ProtClustDB	CLSK750208.
Enzyme and pathway databases
BioCyc	SSP321332:CYB_0287-MONOMER.
Family and domain databases
HAMAP	MF_00490. ComB. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. IPR022995. Pase_ComB. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
KO	K05979.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
SUPFAM	SSF142823. SSF142823. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_SYNJB

Accession

Primary (citable) accession number: Q2JPJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program