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Q2JNK3

- HIS7_SYNJB

UniProt

Q2JNK3 - HIS7_SYNJB

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Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. imidazoleglycerol-phosphate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciSSP321332:GH1B-671-MONOMER.
UniPathwayiUPA00031; UER00011.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydrataseUniRule annotation (EC:4.2.1.19UniRule annotation)
Short name:
IGPDUniRule annotation
Gene namesi
Name:hisBUniRule annotation
Ordered Locus Names:CYB_0671
OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Taxonomic identifieri321332 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001938: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Imidazoleglycerol-phosphate dehydratasePRO_0000336349Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321332.CYB_0671.

Structurei

3D structure databases

ProteinModelPortaliQ2JNK3.
SMRiQ2JNK3. Positions 13-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0131.
HOGENOMiHOG000228064.
KOiK01693.
OMAiFINLDGN.
OrthoDBiEOG60PHGP.

Family and domain databases

HAMAPiMF_00076. HisB.
InterProiIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JNK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTALDSSRLL QPRTASVHRR TGETDVQIHL NLDGSGRHEI DTGIPFLDHM
60 70 80 90 100
LAQLSTHGLI DLQIKAIGDL HIDDHHTNED VGITLGQALA QALQDRRGIH
110 120 130 140 150
RFGHFWAPLD EALVQVVLDF SGRPHLSYGL ELPTERIGRY ETQLVREFYQ
160 170 180 190 200
AVVNHAQLTL HIRQAAGLNA HHIVEASFKA FARALRMAVE RDPRRQEGIP

SSKGVL
Length:206
Mass (Da):23,053
Last modified:March 7, 2006 - v1
Checksum:i1884E00737CEB507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000240 Genomic DNA. Translation: ABD01656.1.
RefSeqiWP_011432314.1. NC_007776.1.
YP_476919.1. NC_007776.1.

Genome annotation databases

EnsemblBacteriaiABD01656; ABD01656; CYB_0671.
GeneIDi3902414.
KEGGicyb:CYB_0671.
PATRICi23803632. VBISynSp29577_0676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000240 Genomic DNA. Translation: ABD01656.1 .
RefSeqi WP_011432314.1. NC_007776.1.
YP_476919.1. NC_007776.1.

3D structure databases

ProteinModelPortali Q2JNK3.
SMRi Q2JNK3. Positions 13-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321332.CYB_0671.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD01656 ; ABD01656 ; CYB_0671 .
GeneIDi 3902414.
KEGGi cyb:CYB_0671.
PATRICi 23803632. VBISynSp29577_0676.

Phylogenomic databases

eggNOGi COG0131.
HOGENOMi HOG000228064.
KOi K01693.
OMAi FINLDGN.
OrthoDBi EOG60PHGP.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00011 .
BioCyci SSP321332:GH1B-671-MONOMER.

Family and domain databases

HAMAPi MF_00076. HisB.
InterProi IPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
Pfami PF00475. IGPD. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 2 hits.
PROSITEi PS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
    Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
    ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JA-2-3B'a(2-13).

Entry informationi

Entry nameiHIS7_SYNJB
AccessioniPrimary (citable) accession number: Q2JNK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3