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Q2JNK3

- HIS7_SYNJB

UniProt

Q2JNK3 - HIS7_SYNJB

Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. imidazoleglycerol-phosphate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciSSP321332:GH1B-671-MONOMER.
    UniPathwayiUPA00031; UER00011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Imidazoleglycerol-phosphate dehydrataseUniRule annotation (EC:4.2.1.19UniRule annotation)
    Short name:
    IGPDUniRule annotation
    Gene namesi
    Name:hisBUniRule annotation
    Ordered Locus Names:CYB_0671
    OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
    Taxonomic identifieri321332 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001938: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Imidazoleglycerol-phosphate dehydratasePRO_0000336349Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi321332.CYB_0671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2JNK3.
    SMRiQ2JNK3. Positions 13-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0131.
    HOGENOMiHOG000228064.
    KOiK01693.
    OMAiFINLDGN.
    OrthoDBiEOG60PHGP.

    Family and domain databases

    HAMAPiMF_00076. HisB.
    InterProiIPR000807. ImidazoleglycerolP_deHydtase.
    IPR020565. ImidazoleglycerP_deHydtase_CS.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PfamiPF00475. IGPD. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 2 hits.
    PROSITEiPS00954. IGP_DEHYDRATASE_1. 1 hit.
    PS00955. IGP_DEHYDRATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2JNK3-1 [UniParc]FASTAAdd to Basket

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    MTALDSSRLL QPRTASVHRR TGETDVQIHL NLDGSGRHEI DTGIPFLDHM    50
    LAQLSTHGLI DLQIKAIGDL HIDDHHTNED VGITLGQALA QALQDRRGIH 100
    RFGHFWAPLD EALVQVVLDF SGRPHLSYGL ELPTERIGRY ETQLVREFYQ 150
    AVVNHAQLTL HIRQAAGLNA HHIVEASFKA FARALRMAVE RDPRRQEGIP 200
    SSKGVL 206
    Length:206
    Mass (Da):23,053
    Last modified:March 7, 2006 - v1
    Checksum:i1884E00737CEB507
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000240 Genomic DNA. Translation: ABD01656.1.
    RefSeqiWP_011432314.1. NC_007776.1.
    YP_476919.1. NC_007776.1.

    Genome annotation databases

    EnsemblBacteriaiABD01656; ABD01656; CYB_0671.
    GeneIDi3902414.
    KEGGicyb:CYB_0671.
    PATRICi23803632. VBISynSp29577_0676.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000240 Genomic DNA. Translation: ABD01656.1 .
    RefSeqi WP_011432314.1. NC_007776.1.
    YP_476919.1. NC_007776.1.

    3D structure databases

    ProteinModelPortali Q2JNK3.
    SMRi Q2JNK3. Positions 13-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321332.CYB_0671.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD01656 ; ABD01656 ; CYB_0671 .
    GeneIDi 3902414.
    KEGGi cyb:CYB_0671.
    PATRICi 23803632. VBISynSp29577_0676.

    Phylogenomic databases

    eggNOGi COG0131.
    HOGENOMi HOG000228064.
    KOi K01693.
    OMAi FINLDGN.
    OrthoDBi EOG60PHGP.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00011 .
    BioCyci SSP321332:GH1B-671-MONOMER.

    Family and domain databases

    HAMAPi MF_00076. HisB.
    InterProi IPR000807. ImidazoleglycerolP_deHydtase.
    IPR020565. ImidazoleglycerP_deHydtase_CS.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    Pfami PF00475. IGPD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 2 hits.
    PROSITEi PS00954. IGP_DEHYDRATASE_1. 1 hit.
    PS00955. IGP_DEHYDRATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
      Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
      ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JA-2-3B'a(2-13).

    Entry informationi

    Entry nameiHIS7_SYNJB
    AccessioniPrimary (citable) accession number: Q2JNK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3