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Q2JNK3 (HIS7_SYNJB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Imidazoleglycerol-phosphate dehydratase

Short name=IGPD
EC=4.2.1.19
Gene names
Name:hisB
Ordered Locus Names:CYB_0671
OrganismSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321332 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00076.

Sequence similarities

Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionimidazoleglycerol-phosphate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076
PRO_0000336349

Sequences

Sequence LengthMass (Da)Tools
Q2JNK3 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 1884E00737CEB507

FASTA20623,053
        10         20         30         40         50         60 
MTALDSSRLL QPRTASVHRR TGETDVQIHL NLDGSGRHEI DTGIPFLDHM LAQLSTHGLI 

        70         80         90        100        110        120 
DLQIKAIGDL HIDDHHTNED VGITLGQALA QALQDRRGIH RFGHFWAPLD EALVQVVLDF 

       130        140        150        160        170        180 
SGRPHLSYGL ELPTERIGRY ETQLVREFYQ AVVNHAQLTL HIRQAAGLNA HHIVEASFKA 

       190        200 
FARALRMAVE RDPRRQEGIP SSKGVL 

« Hide

References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000240 Genomic DNA. Translation: ABD01656.1.
RefSeqYP_476919.1. NC_007776.1.

3D structure databases

ProteinModelPortalQ2JNK3.
SMRQ2JNK3. Positions 13-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321332.CYB_0671.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD01656; ABD01656; CYB_0671.
GeneID3902414.
KEGGcyb:CYB_0671.
PATRIC23803632. VBISynSp29577_0676.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0131.
HOGENOMHOG000228064.
KOK01693.
OMAFINLDGN.
OrthoDBEOG60PHGP.

Enzyme and pathway databases

BioCycSSP321332:GH1B-671-MONOMER.
UniPathwayUPA00031; UER00011.

Family and domain databases

HAMAPMF_00076. HisB.
InterProIPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamPF00475. IGPD. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 2 hits.
PROSITEPS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS7_SYNJB
AccessionPrimary (citable) accession number: Q2JNK3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways