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Q2JM18 (Q2JM18_SYNJB) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840
Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase HAMAP MF_01840
EC=1.14.13.81 HAMAP MF_01840
Gene names
Name:acsF HAMAP MF_01840
Ordered Locus Names:CYB_1254
OrganismSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321332 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840

Catalytic activity

131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840

131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840

Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840

Cofactor

Iron By similarity. HAMAP MF_01840

Pathway

Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840

Sequence similarities

Belongs to the AcsF family. HAMAP MF_01840

Sequences

Sequence LengthMass (Da)Tools
Q2JM18 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: E3D15B38096F9326

FASTA36342,949
        10         20         30         40         50         60 
MSPSLQAAQT QARVPTETIL TPRFYTTDFE AIGKMGLGDR EADFRAILQE FRADYNRHHF 

        70         80         90        100        110        120 
VRGEEFNQDW ESQLDPEARR LFVEFLERSC TAEFSGFLLY KELSRKLKET NPVLAECFAL 

       130        140        150        160        170        180 
MSRDEARHAG FLNRAMGDFN LAFDLSFLTK HKSYTYFAPR FIFYATYLSE KIGYWRYILI 

       190        200        210        220        230        240 
YRHLEAHPED RIYPIFNFFK NWCQDENRHG DFFALMLLSQ PRLLKGWVAK LWCRFFLLSV 

       250        260        270        280        290        300 
FATMYLNDVG ERPDFYRLIG LDPHAYDMEV IYKTNREAAK VFPVVLDVEN PEFVRRLQKC 

       310        320        330        340        350        360 
VANNAKLREI ARGSGPFKGL RKLPLYLDNF YQFLRLFLLK PRKAGFYLWE QPEPRFEGTA 


VSA

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References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000240 Genomic DNA. Translation: ABD02229.1.
RefSeqYP_477492.1. NC_007776.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2JM18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3900988.
GenomeReviewsGene locus CYB_1254 in contig CP000240_GR.
KEGGcyb:CYB_1254.
PATRIC23804822. VBISynSp29577_1265.
TIGRCYB_1254.

Phylogenomic databases

eggNOGNOG10633.
HOGENOMHBG284843.
OMAHGDFFDA.
PhylomeDBQ2JM18.
ProtClustDBPRK13654.

Enzyme and pathway databases

BioCycSSP321332:CYB_1254-MONOMER.

Family and domain databases

HAMAPMF_01840. AcsF.
[Tree]
InterProIPR008434. AcsF.
IPR012347. Ferritin-rel.
IPR009078. Ferritin/RR-like.
IPR003251. Rubrerythrin.
[Graphical view]
Gene3DG3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
KOK04035.
PfamPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMSSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMsTIGR02029. AcsF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2JM18_SYNJB
AccessionPrimary (citable) accession number: Q2JM18
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info