Q2JLM3 (CYSC_SYNJB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylyl-sulfate kinase
EC=2.7.1.25

Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase

Gene names

Name:	cysC
Ordered Locus Names:	CYB_1417

Organism

Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321332 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylylsulfate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000057447
Regions
	Nucleotide binding	12 – 19	8	ATP By similarity
Sites
	Active site	86	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JLM3 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 024F60FBD64E8CD4	FASTA	175	19,543
	10 20 30 40 50 60 MSRRGVTVWF TGLSGAGKTT LSCGVAQQLR AWGLPVEVLD GDLVRQHLTK GLGFSKVDRE 70 80 90 100 110 120 ENIRRIGFVA EMLTRHGVIV LVSAISPYRA ARQEVRRYIG SFIEVFVDAP LEVCERRDVK 130 140 150 160 170 GLYRKARAGL IQHFTGIDDP YEPPEQPEVV CKTAEQSIPE CIDLVIQSLK SRGYV

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000240 Genomic DNA. Translation: ABD02384.1.
RefSeq	YP_477647.1. NC_007776.1.
3D structure databases
ProteinModelPortal	Q2JLM3.
SMR	Q2JLM3. Positions 3-175.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JLM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3901321.
GenomeReviews	Gene locus CYB_1417 in contig CP000240_GR.
KEGG	cyb:CYB_1417.
PATRIC	23805156. VBISynSp29577_1426.
TIGR	CYB_1417.
Phylogenomic databases
eggNOG	COG0529.
HOGENOM	HBG309946.
OMA	LAGEIPH.
PhylomeDB	Q2JLM3.
ProtClustDB	PRK00889.
Enzyme and pathway databases
BioCyc	SSP321332:CYB_1417-MONOMER.
Family and domain databases
HAMAP	MF_00065. Adenylyl_sulf_kinase. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
KO	K00860.
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00455. ApsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_SYNJB

Accession

Primary (citable) accession number: Q2JLM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program