Reviewed, UniProtKB/Swiss-Prot Q2JLM3 (CYSC_SYNJB)

Names and origin

Protein names

Recommended name:
    Adenylyl-sulfate kinase
    EC=2.7.1.25
Alternative name(s):
    APS kinase
    Adenosine-5'-phosphosulfate kinase
    ATP adenosine-5'-phosphosulfate 3'-phosphotransferase

Gene names

Name:	cysC
Ordered Locus Names:	CYB_1417

Organism

Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321332 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylylsulfate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000057447
Regions
	Nucleotide binding	12 – 19	8	ATP By similarity
Sites
	Active site	86	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JLM3-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 024F60FBD64E8CD4	FASTA	175	19,543
	10 20 30 40 50 60 MSRRGVTVWF TGLSGAGKTT LSCGVAQQLR AWGLPVEVLD GDLVRQHLTK GLGFSKVDRE 70 80 90 100 110 120 ENIRRIGFVA EMLTRHGVIV LVSAISPYRA ARQEVRRYIG SFIEVFVDAP LEVCERRDVK 130 140 150 160 170 GLYRKARAGL IQHFTGIDDP YEPPEQPEVV CKTAEQSIPE CIDLVIQSLK SRGYV

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000240 Genomic DNA. Translation: ABD02384.1.
RefSeq	YP_477647.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3901321.
GenomeReviews	Gene locus CYB_1417 in contig CP000240_GR.
KEGG	cyb:CYB_1417.
TIGR	CYB_1417.
Phylogenomic databases
HOGENOM	Q2JLM3.
OMA	Q2JLM3. IITITAF.
Family and domain databases
HAMAP	MF_00065. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
ProDom	PD002350. APS_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00455. apsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_SYNJB

Accession

Primary (citable) accession number: Q2JLM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)