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Q2JKX6 (PGK_SYNJB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase
EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:CYB_1693
OrganismSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321332 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000058076

Regions

Nucleotide binding368 – 3714ATP By similarity
Region26 – 283Substrate binding By similarity
Region65 – 684Substrate binding By similarity

Sites

Binding site421Substrate By similarity
Binding site1331Substrate By similarity
Binding site1661Substrate By similarity
Binding site2171ATP By similarity
Binding site3081ATP; via carbonyl oxygen By similarity
Binding site3391ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2JKX6 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 53269D11F35DFFEA

FASTA41243,532
        10         20         30         40         50         60 
MAKQTLGSLL SSGFDLAGKR VLVRADFNVP LDAQGNITDD TRIRAALPTV QALTQAGAKV 

        70         80         90        100        110        120 
ILTSHLGRPV KKDKETGAVK VAREGNSLAP VATRLSQLLG QPVAFAPDCI GPEAEAVVNR 

       130        140        150        160        170        180 
LENGQVALLE NVRFYPEEED NDPEFARKLA SLADLFVNDA FGSAHRAHAS TAGVTAYLQP 

       190        200        210        220        230        240 
AVAGYLVERE LQFLSGAIED PRRPLAAIIG GSKVSTKIGV IERLLEKVDK LLLGGGMIFT 

       250        260        270        280        290        300 
FYQAQGIQTG KSLVETDKLD LARSLMEKAK ERGVELLLPV DVVVADRFDK DAQAQTVSIH 

       310        320        330        340        350        360 
AIPEDWMGLD IGPESVKAFQ SALQGCQTVV WNGPMGVFEF DRFALGTEAI ARTLADLTQA 

       370        380        390        400        410 
GATTIIGGGD SVAAVEKVGL ADKMTHISTG GGASLELLEG KVLPGIAALT EA

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References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000240 Genomic DNA. Translation: ABD02652.1.
RefSeqYP_477915.1. NC_007776.1.

3D structure databases

ProteinModelPortalQ2JKX6.
SMRQ2JKX6. Positions 1-411.
ModBaseSearch...

Protein-protein interaction databases

STRING321332.CYB_1693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD02652; ABD02652; CYB_1693.
GeneID3901908.
KEGGcyb:CYB_1693.
PATRIC23805718. VBISynSp29577_1701.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.
OMAKFGLADK.
ProtClustDBPRK00073.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. PGK. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_SYNJB
AccessionPrimary (citable) accession number: Q2JKX6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 7, 2006
Last modified: May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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