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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei187 – 1871UniRule annotation
Active sitei629 – 6291UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciSSP321332:GH1B-1842-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:CYB_1842Imported
OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)Imported
Taxonomic identifieri321332 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001938: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi321332.CYB_1842.

Structurei

3D structure databases

ProteinModelPortaliQ2JKJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JKJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSSPHLTAA EGAAGSANGL KEASLFGERD PLAHSLQVNE AFNRRNNLLN
60 70 80 90 100
RRLQLVEELW ESVILQECGQ SLVDLLQRLR SMCSPEGQAL EYPIPEVLQI
110 120 130 140 150
IEYLSLDATI QTARAFALFF QLINIVEQHY ERAEDSDMRM VDSQQRTVRE
160 170 180 190 200
NEKFERLFPY LRAQGVPPGL LRRLLEQLHI RMVFTAHPTE IVRHTIREKQ
210 220 230 240 250
RAFSRLLSQL DWAEQTQPLQ AQMIKEQMAE EVLLWWRTDE LHQSKPTVLN
260 270 280 290 300
EVDYTLHYFE EVLFQAIPLL HEYLSRSLKK AFPSVEPPPA GFCNFGSWVG
310 320 330 340 350
GDRDGNPSVT ADVTWQTARY QRNLILGKYI ESVKALTKTL SISLHWGDVD
360 370 380 390 400
SQLLDALEQD HRLMPEVYES FSLQYRQEPY RLKLSYIQRR LELTRERNRN
410 420 430 440 450
LADSACLPTP PPVDNAYANA EEFLADLQLI QKSLKNSGLS CRQLDHLIQQ
460 470 480 490 500
VQVFGFHLAH LDIRQDSSYH EAALTEIFEY LRILPRPYNE MTEEEKTAFL
510 520 530 540 550
LQELQTRRPL IPLEIAFSEK TAELIATFRT LRRLQQEFGL AICQTYVISM
560 570 580 590 600
SRQLSDLLEV LLMAKEVGLY DPISGRGSLA VVPLFETVED LKRAPEVLRQ
610 620 630 640 650
LLEIPFYRQY LAQQGNLQEV MLGYSDSNKD SGFLSSNWEI YKAQQRLQTV
660 670 680 690 700
AESYGVKLQI FHGRGGSVGR GGGPAYEAIL AQPGRSVGGR IKITEQGEVL
710 720 730 740 750
ASKYSLQDLA IFNLETVTSA VIQASLLRTY PNDLHEWSRL MESLAERSRQ
760 770 780 790 800
VYRNLVYEQE GFVEFFHEVT PIEEISQLQI SSRPARRSGS QKDIGSLRAI
810 820 830 840 850
PWVFSWTQSR FLLPAWYGVG TALQEYVARG EHNLNHLQHL YREWPFFRMV
860 870 880 890 900
ISKVEMTLAK VDLQIARHYV REMSSPERLE RAMELFECIA QEMHRTRTIV
910 920 930 940 950
LQITGHRELL ENDPYLKRSV QLRNRSIVPL GFIQVSLLKR LRERQGSRTG
960 970
RTRYDRAELL RGALLTINGI AAGMRNTG
Length:978
Mass (Da):112,660
Last modified:March 7, 2006 - v1
Checksum:i1C48A452823D584D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000240 Genomic DNA. Translation: ABD02797.1.
RefSeqiWP_011433437.1. NC_007776.1.
YP_478060.1. NC_007776.1.

Genome annotation databases

EnsemblBacteriaiABD02797; ABD02797; CYB_1842.
GeneIDi3900901.
KEGGicyb:CYB_1842.
PATRICi23806018. VBISynSp29577_1848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000240 Genomic DNA. Translation: ABD02797.1.
RefSeqiWP_011433437.1. NC_007776.1.
YP_478060.1. NC_007776.1.

3D structure databases

ProteinModelPortaliQ2JKJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi321332.CYB_1842.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD02797; ABD02797; CYB_1842.
GeneIDi3900901.
KEGGicyb:CYB_1842.
PATRICi23806018. VBISynSp29577_1848.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciSSP321332:GH1B-1842-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
    Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
    ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JA-2-3B'a(2-13)Imported.

Entry informationi

Entry nameiQ2JKJ2_SYNJB
AccessioniPrimary (citable) accession number: Q2JKJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: February 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.