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Q2JK60 (ILVD_SYNJB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase

Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:CYB_1987
OrganismSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321332 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP-Rule MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP-Rule MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP-Rule MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565Dihydroxy-acid dehydratase HAMAP-Rule MF_00012
PRO_0000321608

Sites

Metal binding1261Iron-sulfur (4Fe-4S) Potential
Metal binding1981Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2JK60 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 3CB28147B1DD4C6C

FASTA56559,804
        10         20         30         40         50         60 
MANSPFPLRS QVVTQGVQRS PNRAMLRAVG FRDEDFGKPI VGIANAHSTL TPCNMGIQTL 

        70         80         90        100        110        120 
AERAEAALRT AGCMPQVFGT ITISDGISMG TEGMKYSLVS REVIADSIET VVNGQSMDGL 

       130        140        150        160        170        180 
LAIGGCDKNM PGAMIAMARL NVPSIFVYGG TIKPGHYNGR DLTIVSAFEA VGEFSAGRIS 

       190        200        210        220        230        240 
EEELLAVERH ACPGAGSCGG MYTANTMSSA FEAMGMSLPY SSTMAAEDEE KAESAAQSAK 

       250        260        270        280        290        300 
VLAEAIKANI RPRDIITRKS IENAISVIMA VGGSTNAVLH FLAIAHAAEV PLTLDDFETI 

       310        320        330        340        350        360 
RARVPVLCDL KPSGRFVATD LHRAGGIPQV MKMLLNHGLL HGDCLTISGQ TIVEVLRDVP 

       370        380        390        400        410        420 
DEPSPDQEVI RPWHSPLYPQ GHLAILKGNL APEGAVAKIT GVKNPQITGP ARVFDSEESC 

       430        440        450        460        470        480 
LQAILSGQIR AGDVVVIRYE GPKGGPGMRE MLSPTSAIIG AGLGDSVGLI TDGRFSGGTY 

       490        500        510        520        530        540 
GMVVGHVAPE AYVGGTIALV EEGDLITIDA PARQLHLHVS EEELARRRAR WSPPEPRYKR 

       550        560 
GTLAKYAKLV SSSSLGAVTD LNLWD 

« Hide

References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000240 Genomic DNA. Translation: ABD02935.1.
RefSeqYP_478198.1. NC_007776.1.

3D structure databases

ProteinModelPortalQ2JK60.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321332.CYB_1987.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD02935; ABD02935; CYB_1987.
GeneID3900000.
KEGGcyb:CYB_1987.
PATRIC23806322. VBISynSp29577_1995.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0129.
HOGENOMHOG000173155.
KOK01687.
OMADWTIDDF.
OrthoDBEOG6MSS24.
ProtClustDBPRK00911.

Enzyme and pathway databases

BioCycSSP321332:GH1B-1987-MONOMER.
UniPathwayUPA00047; UER00057.
UPA00049; UER00061.

Family and domain databases

HAMAPMF_00012. IlvD.
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERPTHR21000. PTHR21000. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. SSF52016. 1 hit.
TIGRFAMsTIGR00110. ilvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_SYNJB
AccessionPrimary (citable) accession number: Q2JK60
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways