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Q2JK60

- ILVD_SYNJB

UniProt

Q2JK60 - ILVD_SYNJB

Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi126 – 1261Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi198 – 1981Iron-sulfur (4Fe-4S)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. dihydroxy-acid dehydratase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciSSP321332:GH1B-1987-MONOMER.
    UniPathwayiUPA00047; UER00057.
    UPA00049; UER00061.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
    Short name:
    DADUniRule annotation
    Gene namesi
    Name:ilvDUniRule annotation
    Ordered Locus Names:CYB_1987
    OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
    Taxonomic identifieri321332 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001938: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Dihydroxy-acid dehydratasePRO_0000321608Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi321332.CYB_1987.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2JK60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IlvD/Edd family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0129.
    HOGENOMiHOG000173155.
    KOiK01687.
    OMAiPENQDVI.
    OrthoDBiEOG6MSS24.

    Family and domain databases

    HAMAPiMF_00012. IlvD.
    InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR004404. DihydroxyA_deHydtase.
    IPR000581. DiOHA_6PGluconate_deHydtase.
    IPR020558. DiOHA_6PGluconate_deHydtase_CS.
    [Graphical view]
    PANTHERiPTHR21000. PTHR21000. 1 hit.
    PfamiPF00920. ILVD_EDD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52016. SSF52016. 1 hit.
    TIGRFAMsiTIGR00110. ilvD. 1 hit.
    PROSITEiPS00886. ILVD_EDD_1. 1 hit.
    PS00887. ILVD_EDD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2JK60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANSPFPLRS QVVTQGVQRS PNRAMLRAVG FRDEDFGKPI VGIANAHSTL    50
    TPCNMGIQTL AERAEAALRT AGCMPQVFGT ITISDGISMG TEGMKYSLVS 100
    REVIADSIET VVNGQSMDGL LAIGGCDKNM PGAMIAMARL NVPSIFVYGG 150
    TIKPGHYNGR DLTIVSAFEA VGEFSAGRIS EEELLAVERH ACPGAGSCGG 200
    MYTANTMSSA FEAMGMSLPY SSTMAAEDEE KAESAAQSAK VLAEAIKANI 250
    RPRDIITRKS IENAISVIMA VGGSTNAVLH FLAIAHAAEV PLTLDDFETI 300
    RARVPVLCDL KPSGRFVATD LHRAGGIPQV MKMLLNHGLL HGDCLTISGQ 350
    TIVEVLRDVP DEPSPDQEVI RPWHSPLYPQ GHLAILKGNL APEGAVAKIT 400
    GVKNPQITGP ARVFDSEESC LQAILSGQIR AGDVVVIRYE GPKGGPGMRE 450
    MLSPTSAIIG AGLGDSVGLI TDGRFSGGTY GMVVGHVAPE AYVGGTIALV 500
    EEGDLITIDA PARQLHLHVS EEELARRRAR WSPPEPRYKR GTLAKYAKLV 550
    SSSSLGAVTD LNLWD 565
    Length:565
    Mass (Da):59,804
    Last modified:March 7, 2006 - v1
    Checksum:i3CB28147B1DD4C6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000240 Genomic DNA. Translation: ABD02935.1.
    RefSeqiWP_011433574.1. NC_007776.1.
    YP_478198.1. NC_007776.1.

    Genome annotation databases

    EnsemblBacteriaiABD02935; ABD02935; CYB_1987.
    GeneIDi3900000.
    KEGGicyb:CYB_1987.
    PATRICi23806322. VBISynSp29577_1995.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000240 Genomic DNA. Translation: ABD02935.1 .
    RefSeqi WP_011433574.1. NC_007776.1.
    YP_478198.1. NC_007776.1.

    3D structure databases

    ProteinModelPortali Q2JK60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321332.CYB_1987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD02935 ; ABD02935 ; CYB_1987 .
    GeneIDi 3900000.
    KEGGi cyb:CYB_1987.
    PATRICi 23806322. VBISynSp29577_1995.

    Phylogenomic databases

    eggNOGi COG0129.
    HOGENOMi HOG000173155.
    KOi K01687.
    OMAi PENQDVI.
    OrthoDBi EOG6MSS24.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00057 .
    UPA00049 ; UER00061 .
    BioCyci SSP321332:GH1B-1987-MONOMER.

    Family and domain databases

    HAMAPi MF_00012. IlvD.
    InterProi IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR004404. DihydroxyA_deHydtase.
    IPR000581. DiOHA_6PGluconate_deHydtase.
    IPR020558. DiOHA_6PGluconate_deHydtase_CS.
    [Graphical view ]
    PANTHERi PTHR21000. PTHR21000. 1 hit.
    Pfami PF00920. ILVD_EDD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52016. SSF52016. 1 hit.
    TIGRFAMsi TIGR00110. ilvD. 1 hit.
    PROSITEi PS00886. ILVD_EDD_1. 1 hit.
    PS00887. ILVD_EDD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
      Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
      ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JA-2-3B'a(2-13).

    Entry informationi

    Entry nameiILVD_SYNJB
    AccessioniPrimary (citable) accession number: Q2JK60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3