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Q2JK60

- ILVD_SYNJB

UniProt

Q2JK60 - ILVD_SYNJB

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Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi198 – 1981Iron-sulfur (4Fe-4S)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. dihydroxy-acid dehydratase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSSP321332:GH1B-1987-MONOMER.
UniPathwayiUPA00047; UER00057.
UPA00049; UER00061.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
Short name:
DADUniRule annotation
Gene namesi
Name:ilvDUniRule annotation
Ordered Locus Names:CYB_1987
OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Taxonomic identifieri321332 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001938: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Dihydroxy-acid dehydratasePRO_0000321608Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321332.CYB_1987.

Structurei

3D structure databases

ProteinModelPortaliQ2JK60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0129.
HOGENOMiHOG000173155.
KOiK01687.
OMAiPENQDVI.
OrthoDBiEOG6MSS24.

Family and domain databases

HAMAPiMF_00012. IlvD.
InterProiIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERiPTHR21000. PTHR21000. 1 hit.
PfamiPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00110. ilvD. 1 hit.
PROSITEiPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JK60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANSPFPLRS QVVTQGVQRS PNRAMLRAVG FRDEDFGKPI VGIANAHSTL
60 70 80 90 100
TPCNMGIQTL AERAEAALRT AGCMPQVFGT ITISDGISMG TEGMKYSLVS
110 120 130 140 150
REVIADSIET VVNGQSMDGL LAIGGCDKNM PGAMIAMARL NVPSIFVYGG
160 170 180 190 200
TIKPGHYNGR DLTIVSAFEA VGEFSAGRIS EEELLAVERH ACPGAGSCGG
210 220 230 240 250
MYTANTMSSA FEAMGMSLPY SSTMAAEDEE KAESAAQSAK VLAEAIKANI
260 270 280 290 300
RPRDIITRKS IENAISVIMA VGGSTNAVLH FLAIAHAAEV PLTLDDFETI
310 320 330 340 350
RARVPVLCDL KPSGRFVATD LHRAGGIPQV MKMLLNHGLL HGDCLTISGQ
360 370 380 390 400
TIVEVLRDVP DEPSPDQEVI RPWHSPLYPQ GHLAILKGNL APEGAVAKIT
410 420 430 440 450
GVKNPQITGP ARVFDSEESC LQAILSGQIR AGDVVVIRYE GPKGGPGMRE
460 470 480 490 500
MLSPTSAIIG AGLGDSVGLI TDGRFSGGTY GMVVGHVAPE AYVGGTIALV
510 520 530 540 550
EEGDLITIDA PARQLHLHVS EEELARRRAR WSPPEPRYKR GTLAKYAKLV
560
SSSSLGAVTD LNLWD
Length:565
Mass (Da):59,804
Last modified:March 7, 2006 - v1
Checksum:i3CB28147B1DD4C6C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000240 Genomic DNA. Translation: ABD02935.1.
RefSeqiWP_011433574.1. NC_007776.1.
YP_478198.1. NC_007776.1.

Genome annotation databases

EnsemblBacteriaiABD02935; ABD02935; CYB_1987.
GeneIDi3900000.
KEGGicyb:CYB_1987.
PATRICi23806322. VBISynSp29577_1995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000240 Genomic DNA. Translation: ABD02935.1 .
RefSeqi WP_011433574.1. NC_007776.1.
YP_478198.1. NC_007776.1.

3D structure databases

ProteinModelPortali Q2JK60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321332.CYB_1987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD02935 ; ABD02935 ; CYB_1987 .
GeneIDi 3900000.
KEGGi cyb:CYB_1987.
PATRICi 23806322. VBISynSp29577_1995.

Phylogenomic databases

eggNOGi COG0129.
HOGENOMi HOG000173155.
KOi K01687.
OMAi PENQDVI.
OrthoDBi EOG6MSS24.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00057 .
UPA00049 ; UER00061 .
BioCyci SSP321332:GH1B-1987-MONOMER.

Family and domain databases

HAMAPi MF_00012. IlvD.
InterProi IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view ]
PANTHERi PTHR21000. PTHR21000. 1 hit.
Pfami PF00920. ILVD_EDD. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00110. ilvD. 1 hit.
PROSITEi PS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
    Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
    ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JA-2-3B'a(2-13).

Entry informationi

Entry nameiILVD_SYNJB
AccessioniPrimary (citable) accession number: Q2JK60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 7, 2006
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3