Q2JJG9 (FBSB_SYNJB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase
Short name=FBPase class 2/SBPase
EC=3.1.3.11
EC=3.1.3.37

Gene names

Ordered Locus Names:

CYB_2257

Organism

Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321332 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6-phosphate and sedoheptulose 7-phosphate, respectively By similarity.
Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. Sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate.
Cofactor	Manganese By similarity.
Pathway	Carbohydrate biosynthesis; Calvin cycle.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the FBPase class 2 family.

Ontologies

Keywords
Biological process	Calvin cycle Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: InterPro reductive pentose-phosphate cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sedoheptulose-bisphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	D-fructose 1,6-bisphosphatase class 2/sedoheptulose 1,7-bisphosphatase		PRO_0000342730
Regions
	Region	100 – 102	3	Substrate binding By similarity
	Region	176 – 178	3	Substrate binding By similarity
	Region	198 – 200	3	Substrate binding By similarity
Sites
	Metal binding	33	1	Manganese 1 By similarity
	Metal binding	57	1	Manganese 1 By similarity
	Metal binding	97	1	Manganese 2 By similarity
	Metal binding	100	1	Manganese 2 By similarity
	Metal binding	225	1	Manganese 2 By similarity
	Binding site	131	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JJG9 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 0EEBD5BC10CB5E87	FASTA	347	37,715
	10 20 30 40 50 60 MDNKLGLEII EVVEQAAIAA ARWMGKGDNK TADQVAVEAM REKLNQIPMR GRIVIGEGTR 70 80 90 100 110 120 DEAPMLYIGE EVGICTRPDA EQFCRVEELV EIDIAVDPCE GTNLVAKGQN GSMAVLAISE 130 140 150 160 170 180 KGGLLHAPDI YMQKLAAPPQ AKGKVHIDYP PEKNLKIIAE SLDREISDLT VVVMDRKRHL 190 200 210 220 230 240 DLIRQIREAG ARVKLITDGD ISAALSAGFN GTGIHALMGI GAAPEGVISA AALRCLGAHF 250 260 270 280 290 300 QGRLIYDPEV VQAGTYLPPV EETRRELKEK GIEDPDKVWE CEELASGKEV LFAATGITDG 310 320 330 340 DLMRGVRFFG GGARTETLVI SSQSRTVRFV DTIHMKDGQQ PRGLQLR

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000240 Genomic DNA. Translation: ABD03198.1.
RefSeq	YP_478461.1. NC_007776.1.
3D structure databases
ProteinModelPortal	Q2JJG9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JJG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3900420.
GenomeReviews	Gene locus CYB_2257 in contig CP000240_GR.
KEGG	cyb:CYB_2257.
PATRIC	23806864. VBISynSp29577_2261.
TIGR	CYB_2257.
Phylogenomic databases
eggNOG	COG1494.
HOGENOM	HBG284837.
OMA	TSEWADM.
PhylomeDB	Q2JJG9.
ProtClustDB	PRK09479.
Enzyme and pathway databases
BioCyc	SSP321332:CYB_2257-MONOMER.
Family and domain databases
InterPro	IPR004464. FBPase_class-2/SBPase. [Graphical view]
KO	K11532.
Pfam	PF03320. FBPase_glpX. 1 hit. [Graphical view]
PIRSF	PIRSF004532. GlpX. 1 hit.
TIGRFAMs	TIGR00330. GlpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FBSB_SYNJB

Accession

Primary (citable) accession number: Q2JJG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program