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Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional pantoate ligase/cytidylate kinase (panC/cmk)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton donorUniRule annotation1
Binding sitei59Beta-alanineUniRule annotation1
Binding sitei59PantoateUniRule annotation1
Binding sitei156PantoateUniRule annotation1
Binding sitei179ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35ATPUniRule annotation8
Nucleotide bindingi150 – 153ATPUniRule annotation4
Nucleotide bindingi187 – 190ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Ligase, Multifunctional enzyme, Transferase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP321332:G1G5P-2323-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
Including the following 2 domains:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:panC/cmkUniRule annotation
Ordered Locus Names:CYB_2425
OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Taxonomic identifieri321332 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001938 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397961 – 542Bifunctional pantoate ligase/cytidylate kinaseAdd BLAST542

Proteomic databases

PRIDEiQ2JJ30

Interactioni

Protein-protein interaction databases

STRINGi321332.CYB_2425

Structurei

3D structure databases

ProteinModelPortaliQ2JJ30
SMRiQ2JJ30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 280Pantoate--beta-alanine ligaseUniRule annotationAdd BLAST280
Regioni281 – 542Cytidylate kinaseUniRule annotationAdd BLAST262

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAT Bacteria
COG0283 LUCA
COG0414 LUCA
HOGENOMiHOG000233355
KOiK13799
OMAiLGEKDWQ
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00238 Cytidyl_kinase_type1, 1 hit
MF_00158 PanC, 1 hit
MF_01349 PanCY, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003136 Cytidylate_kin
IPR011994 Cytidylate_kinase_dom
IPR027417 P-loop_NTPase
IPR003721 Pantoate_ligase
IPR024894 Pantoate_ligase/cytidylate_kin
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF02224 Cytidylate_kin, 1 hit
PF02569 Pantoate_ligase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00017 cmk, 1 hit
TIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2JJ30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWLRTVAAL REQVADWRGS TVGLVPTMGS LHEGHLSLIR RCRQECDHTV
60 70 80 90 100
VSIFVNPLQF GPNEDWDRYP RDEEGDRALC EAAGVDVVFA PDPQEMGADP
110 120 130 140 150
ATGSDRTWVM PPESLLQTLC APHRPGHFRG VATIVLQLLN LVQPQRAYFG
160 170 180 190 200
QKDAQQLAII QRLVRDLQIP TTIVPCSTVR EADGLACSSR NRYLSAAERQ
210 220 230 240 250
VAAGLYRALR RGYDHWQAGD PSAEGILAAA RAELEHTPEL QLQYLELVDP
260 270 280 290 300
QTLQPLPRVE DKGLLAIAAY VGQTRLIDNL LLSPEQGDPL PERVQHAAPP
310 320 330 340 350
SSGTTSPPRR PLIAIDGPAG AGKSTVARAV AAQLQLLYLD TGAMYRAITW
360 370 380 390 400
LALQRGIPLD DAEQLTQLAA QTQLTLQSGT SSTEPTRIWA DGEEITQAIR
410 420 430 440 450
SPEVTRWVSH VAAVPGVRQE LVKRQRSIGR DGGAVLEGRD IGTHVFPDAE
460 470 480 490 500
LKVFLTASVG ERAQRRQHQL QAQGQMVPLE ELKAQIEQRD RRDSERLISP
510 520 530 540
LRPAPDAILI DTDHLSQSEV QDKIVMLYRQ LLERSGPARL DQ
Length:542
Mass (Da):59,857
Last modified:March 7, 2006 - v1
Checksum:iBE1BF4BB355F078A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000240 Genomic DNA Translation: ABD03359.1
RefSeqiWP_011433988.1, NC_007776.1

Genome annotation databases

EnsemblBacteriaiABD03359; ABD03359; CYB_2425
KEGGicyb:CYB_2425

Similar proteinsi

Entry informationi

Entry nameiPANCY_SYNJB
AccessioniPrimary (citable) accession number: Q2JJ30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health