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Reviewed, UniProtKB/Swiss-Prot Q2JJ30 (PANCY_SYNJB)

Last modified February 9, 2010. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
    1- Recommended name:
            Pantoate--beta-alanine ligase
              EC=6.3.2.1
        Alternative name(s):
            Pantothenate synthetase
            Pantoate-activating enzyme
    2- Recommended name:
            Cytidylate kinase
                Short name=CK
              EC=2.7.4.14
        Alternative name(s):
            Cytidine monophosphate kinase
              Short name=CMP kinase
Gene names
Name: panC/cmk
Ordered Locus Names: CYB_2425
OrganismSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321332 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaChroococcalesSynechococcus

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_01349

ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_01349

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_01349

Subcellular location

Cytoplasm By similarity HAMAP MF_01349.

Sequence similarities

In the N-terminal section; belongs to the pantothenate synthetase family.

In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Bifunctional pantoate ligase/cytidylate kinase HAMAP MF_01349
PRO_0000239796

Regions

Nucleotide binding317 – 3259ATP By similarity
Region1 – 280280Pantoate--beta-alanine ligase HAMAP MF_01349
Region281 – 542262Cytidylate kinase HAMAP MF_01349

Sequences

Sequence LengthMass (Da)Tools
Q2JJ30-1 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: BE1BF4BB355F078A

FASTA54259,857
        10         20         30         40         50         60 
MHWLRTVAAL REQVADWRGS TVGLVPTMGS LHEGHLSLIR RCRQECDHTV VSIFVNPLQF 

        70         80         90        100        110        120 
GPNEDWDRYP RDEEGDRALC EAAGVDVVFA PDPQEMGADP ATGSDRTWVM PPESLLQTLC 

       130        140        150        160        170        180 
APHRPGHFRG VATIVLQLLN LVQPQRAYFG QKDAQQLAII QRLVRDLQIP TTIVPCSTVR 

       190        200        210        220        230        240 
EADGLACSSR NRYLSAAERQ VAAGLYRALR RGYDHWQAGD PSAEGILAAA RAELEHTPEL 

       250        260        270        280        290        300 
QLQYLELVDP QTLQPLPRVE DKGLLAIAAY VGQTRLIDNL LLSPEQGDPL PERVQHAAPP 

       310        320        330        340        350        360 
SSGTTSPPRR PLIAIDGPAG AGKSTVARAV AAQLQLLYLD TGAMYRAITW LALQRGIPLD 

       370        380        390        400        410        420 
DAEQLTQLAA QTQLTLQSGT SSTEPTRIWA DGEEITQAIR SPEVTRWVSH VAAVPGVRQE 

       430        440        450        460        470        480 
LVKRQRSIGR DGGAVLEGRD IGTHVFPDAE LKVFLTASVG ERAQRRQHQL QAQGQMVPLE 

       490        500        510        520        530        540 
ELKAQIEQRD RRDSERLISP LRPAPDAILI DTDHLSQSEV QDKIVMLYRQ LLERSGPARL 


DQ 

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References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000240 Genomic DNA. Translation: ABD03359.1.
RefSeqYP_478622.1.

3D structure databases

SMRQ2JJ30. Positions 1-284, 312-531.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2JJ30.

Genome annotation databases

GeneID3901394.
GenomeReviewsGene locus CYB_2425 in contig CP000240_GR.
KEGGcyb:CYB_2425.
TIGRCYB_2425.

Phylogenomic databases

eggNOGCOG0414.
HOGENOMHBG428839.
OMALGEKDWQ.
PhylomeDBQ2JJ30.

Family and domain databases

HAMAPMF_01349. PanCY.
[Tree]
InterProIPR004821. Cyt_trans_rel.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHERPTHR21299:SF1. Pantoate_ligase. 1 hit.
PfamPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANCY_SYNJB
AccessionPrimary (citable) accession number: Q2JJ30
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: February 9, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents