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Q2JJ30 (PANCY_SYNJB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional pantoate ligase/cytidylate kinase

Including the following 2 domains:

  1. Pantoate--beta-alanine ligase
    EC=6.3.2.1
    Alternative name(s):
    Pantoate-activating enzyme
    Pantothenate synthetase
  2. Cytidylate kinase
    Short name=CK
    EC=2.7.4.14
    Alternative name(s):
    Cytidine monophosphate kinase
    Short name=CMP kinase
Gene names
Name:panC/cmk
Ordered Locus Names:CYB_2425
OrganismSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321332 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158.

Sequence similarities

In the N-terminal section; belongs to the pantothenate synthetase family.

In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Ligase
Transferase
   Technical termComplete proteome
Multifunctional enzyme
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyrimidine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cytidylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pantoate-beta-alanine ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Bifunctional pantoate ligase/cytidylate kinase HAMAP-Rule MF_00158
PRO_0000239796

Regions

Nucleotide binding317 – 3259ATP By similarity
Region1 – 280280Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
Region281 – 542262Cytidylate kinase HAMAP-Rule MF_00158

Sequences

Sequence LengthMass (Da)Tools
Q2JJ30 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: BE1BF4BB355F078A

FASTA54259,857
        10         20         30         40         50         60 
MHWLRTVAAL REQVADWRGS TVGLVPTMGS LHEGHLSLIR RCRQECDHTV VSIFVNPLQF 

        70         80         90        100        110        120 
GPNEDWDRYP RDEEGDRALC EAAGVDVVFA PDPQEMGADP ATGSDRTWVM PPESLLQTLC 

       130        140        150        160        170        180 
APHRPGHFRG VATIVLQLLN LVQPQRAYFG QKDAQQLAII QRLVRDLQIP TTIVPCSTVR 

       190        200        210        220        230        240 
EADGLACSSR NRYLSAAERQ VAAGLYRALR RGYDHWQAGD PSAEGILAAA RAELEHTPEL 

       250        260        270        280        290        300 
QLQYLELVDP QTLQPLPRVE DKGLLAIAAY VGQTRLIDNL LLSPEQGDPL PERVQHAAPP 

       310        320        330        340        350        360 
SSGTTSPPRR PLIAIDGPAG AGKSTVARAV AAQLQLLYLD TGAMYRAITW LALQRGIPLD 

       370        380        390        400        410        420 
DAEQLTQLAA QTQLTLQSGT SSTEPTRIWA DGEEITQAIR SPEVTRWVSH VAAVPGVRQE 

       430        440        450        460        470        480 
LVKRQRSIGR DGGAVLEGRD IGTHVFPDAE LKVFLTASVG ERAQRRQHQL QAQGQMVPLE 

       490        500        510        520        530        540 
ELKAQIEQRD RRDSERLISP LRPAPDAILI DTDHLSQSEV QDKIVMLYRQ LLERSGPARL 


DQ 

« Hide

References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000240 Genomic DNA. Translation: ABD03359.1.
RefSeqYP_478622.1. NC_007776.1.

3D structure databases

ProteinModelPortalQ2JJ30.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321332.CYB_2425.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD03359; ABD03359; CYB_2425.
GeneID3901394.
KEGGcyb:CYB_2425.
PATRIC23807200. VBISynSp29577_2425.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0283.
HOGENOMHOG000233355.
KOK13799.
OMALGEKDWQ.
OrthoDBEOG6Z6FZ4.

Enzyme and pathway databases

BioCycSSP321332:GH1B-2425-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProIPR004821. Cyt_trans-like.
IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00017. cmk. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANCY_SYNJB
AccessionPrimary (citable) accession number: Q2JJ30
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways