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Q2JIY1 (Q2JIY1_SYNJB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL ABD03413.1
Ordered Locus Names:CYB_2481
OrganismSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP] EMBL ABD03413.1
Taxonomic identifier321332 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU000485

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000109-3
Region129 – 1313Substrate binding By similarity PIRSR PIRSR000109-2
Region186 – 1872Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1831Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1901Proton donor By similarity PIRSR PIRSR000109-1
Binding site1031NADP By similarity PIRSR PIRSR000109-3
Binding site1031Substrate By similarity PIRSR PIRSR000109-2
Binding site1911Substrate By similarity PIRSR PIRSR000109-2
Binding site2611Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2881Substrate By similarity PIRSR PIRSR000109-2
Binding site4461Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4521Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q2JIY1 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: D1C7C9A64FC4C2CF

FASTA47251,844
        10         20         30         40         50         60 
MSKPSFAVIG LAVMGENLAL NVERNGFPVA VYNRTSSKTD QFMRERAQGK RITPAYSLPE 

        70         80         90        100        110        120 
LVQLMERPRK FLIMVKAGAP VDAVIDELKP LLDPGDIIID GGNSLYTDTD RRAEALAPTG 

       130        140        150        160        170        180 
IHFVGMGVSG GEEGALNGPS LMPGCSPEAY QQLEPILAKI AAQVPDGPCV TYLGPKGGGH 

       190        200        210        220        230        240 
YVKMVHNGIE YGDMQLIAEV YDLMRRALKL SASQMQEIFQ AWNETELESF LIEITAKIFQ 

       250        260        270        280        290        300 
TLDPETGKPL VDLILDKAGQ KGTGLWTVKD ALDLGVPVPT IEAAVQARIL SSMKEERVAA 

       310        320        330        340        350        360 
SAQLKGPDAT FAGDPDCFIQ DLRAALYCSK ICSYAQGMAL LKRATVAHGY VYTFSEIPRI 

       370        380        390        400        410        420 
WKGGCIIRAR FLGEIQSAYK RDPELVNLLL DEEFEQAIRE RQGSWRRVVS TAAALGIPIP 

       430        440        450        460        470 
AISASLAYYD SYRTANLPQN LTQAQRDFFG AHTFERIDRP GVFHHEWNAC CR

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References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000240 Genomic DNA. Translation: ABD03413.1.
RefSeqYP_478676.1. NC_007776.1.

3D structure databases

ProteinModelPortalQ2JIY1.
SMRQ2JIY1. Positions 1-468.
ModBaseSearch...

Protein-protein interaction databases

STRING321332.CYB_2481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD03413; ABD03413; CYB_2481.
GeneID3902474.
KEGGcyb:CYB_2481.
PATRIC23807312. VBISynSp29577_2481.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHOG000255147.
KOK00033.
OMAKQQIGVI.
ProtClustDBCLSK750283.

Enzyme and pathway databases

UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ2JIY1_SYNJB
AccessionPrimary (citable) accession number: Q2JIY1
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info