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Q2JIY1

- Q2JIY1_SYNJB

UniProt

Q2JIY1 - Q2JIY1_SYNJB

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031NADPUniRule annotation
    Binding sitei103 – 1031SubstrateUniRule annotation
    Active sitei183 – 1831Proton acceptorUniRule annotation
    Active sitei190 – 1901Proton donorUniRule annotation
    Binding sitei191 – 1911SubstrateUniRule annotation
    Binding sitei261 – 2611Substrate; via amide nitrogenUniRule annotation
    Binding sitei288 – 2881SubstrateUniRule annotation
    Binding sitei446 – 4461Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei452 – 4521Substrate; shared with dimeric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADPUniRule annotation
    Nucleotide bindingi33 – 353NADPUniRule annotation
    Nucleotide bindingi75 – 773NADPUniRule annotation

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Gluconate utilizationUniRule annotation, Pentose shuntUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSSP321332:GH1B-2480-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
    Gene namesi
    Name:gndImported
    Ordered Locus Names:CYB_2481Imported
    OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)Imported
    Taxonomic identifieri321332 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001938: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi321332.CYB_2481.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2JIY1.
    SMRiQ2JIY1. Positions 1-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni129 – 1313Substrate bindingUniRule annotation
    Regioni186 – 1872Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0362.
    HOGENOMiHOG000255147.
    KOiK00033.
    OMAiETYQDAW.
    OrthoDBiEOG6MSS4W.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.
    PROSITEiPS00461. 6PGD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2JIY1-1 [UniParc]FASTAAdd to Basket

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    MSKPSFAVIG LAVMGENLAL NVERNGFPVA VYNRTSSKTD QFMRERAQGK    50
    RITPAYSLPE LVQLMERPRK FLIMVKAGAP VDAVIDELKP LLDPGDIIID 100
    GGNSLYTDTD RRAEALAPTG IHFVGMGVSG GEEGALNGPS LMPGCSPEAY 150
    QQLEPILAKI AAQVPDGPCV TYLGPKGGGH YVKMVHNGIE YGDMQLIAEV 200
    YDLMRRALKL SASQMQEIFQ AWNETELESF LIEITAKIFQ TLDPETGKPL 250
    VDLILDKAGQ KGTGLWTVKD ALDLGVPVPT IEAAVQARIL SSMKEERVAA 300
    SAQLKGPDAT FAGDPDCFIQ DLRAALYCSK ICSYAQGMAL LKRATVAHGY 350
    VYTFSEIPRI WKGGCIIRAR FLGEIQSAYK RDPELVNLLL DEEFEQAIRE 400
    RQGSWRRVVS TAAALGIPIP AISASLAYYD SYRTANLPQN LTQAQRDFFG 450
    AHTFERIDRP GVFHHEWNAC CR 472
    Length:472
    Mass (Da):51,844
    Last modified:March 7, 2006 - v1
    Checksum:iD1C7C9A64FC4C2CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000240 Genomic DNA. Translation: ABD03413.1.
    RefSeqiWP_011434040.1. NC_007776.1.
    YP_478676.1. NC_007776.1.

    Genome annotation databases

    EnsemblBacteriaiABD03413; ABD03413; CYB_2481.
    GeneIDi3902474.
    KEGGicyb:CYB_2481.
    PATRICi23807312. VBISynSp29577_2481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000240 Genomic DNA. Translation: ABD03413.1 .
    RefSeqi WP_011434040.1. NC_007776.1.
    YP_478676.1. NC_007776.1.

    3D structure databases

    ProteinModelPortali Q2JIY1.
    SMRi Q2JIY1. Positions 1-468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321332.CYB_2481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD03413 ; ABD03413 ; CYB_2481 .
    GeneIDi 3902474.
    KEGGi cyb:CYB_2481.
    PATRICi 23807312. VBISynSp29577_2481.

    Phylogenomic databases

    eggNOGi COG0362.
    HOGENOMi HOG000255147.
    KOi K00033.
    OMAi ETYQDAW.
    OrthoDBi EOG6MSS4W.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci SSP321332:GH1B-2480-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR006184. 6PGdom_BS.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    PROSITEi PS00461. 6PGD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
      Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
      ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JA-2-3B'a(2-13)Imported.

    Entry informationi

    Entry nameiQ2JIY1_SYNJB
    AccessioniPrimary (citable) accession number: Q2JIY1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3