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Q2JIY1

- Q2JIY1_SYNJB

UniProt

Q2JIY1 - Q2JIY1_SYNJB

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031NADPUniRule annotation
Binding sitei103 – 1031SubstrateUniRule annotation
Active sitei183 – 1831Proton acceptorUniRule annotation
Active sitei190 – 1901Proton donorUniRule annotation
Binding sitei191 – 1911SubstrateUniRule annotation
Binding sitei261 – 2611Substrate; via amide nitrogenUniRule annotation
Binding sitei288 – 2881SubstrateUniRule annotation
Binding sitei446 – 4461Substrate; shared with dimeric partnerUniRule annotation
Binding sitei452 – 4521Substrate; shared with dimeric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADPUniRule annotation
Nucleotide bindingi33 – 353NADPUniRule annotation
Nucleotide bindingi75 – 773NADPUniRule annotation

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Gluconate utilizationUniRule annotation, Pentose shuntUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciSSP321332:GH1B-2480-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
Name:gndImported
Ordered Locus Names:CYB_2481Imported
OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)Imported
Taxonomic identifieri321332 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001938: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi321332.CYB_2481.

Structurei

3D structure databases

ProteinModelPortaliQ2JIY1.
SMRiQ2JIY1. Positions 1-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1313Substrate bindingUniRule annotation
Regioni186 – 1872Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
KOiK00033.
OMAiETYQDAW.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JIY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKPSFAVIG LAVMGENLAL NVERNGFPVA VYNRTSSKTD QFMRERAQGK
60 70 80 90 100
RITPAYSLPE LVQLMERPRK FLIMVKAGAP VDAVIDELKP LLDPGDIIID
110 120 130 140 150
GGNSLYTDTD RRAEALAPTG IHFVGMGVSG GEEGALNGPS LMPGCSPEAY
160 170 180 190 200
QQLEPILAKI AAQVPDGPCV TYLGPKGGGH YVKMVHNGIE YGDMQLIAEV
210 220 230 240 250
YDLMRRALKL SASQMQEIFQ AWNETELESF LIEITAKIFQ TLDPETGKPL
260 270 280 290 300
VDLILDKAGQ KGTGLWTVKD ALDLGVPVPT IEAAVQARIL SSMKEERVAA
310 320 330 340 350
SAQLKGPDAT FAGDPDCFIQ DLRAALYCSK ICSYAQGMAL LKRATVAHGY
360 370 380 390 400
VYTFSEIPRI WKGGCIIRAR FLGEIQSAYK RDPELVNLLL DEEFEQAIRE
410 420 430 440 450
RQGSWRRVVS TAAALGIPIP AISASLAYYD SYRTANLPQN LTQAQRDFFG
460 470
AHTFERIDRP GVFHHEWNAC CR
Length:472
Mass (Da):51,844
Last modified:March 7, 2006 - v1
Checksum:iD1C7C9A64FC4C2CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000240 Genomic DNA. Translation: ABD03413.1.
RefSeqiWP_011434040.1. NC_007776.1.
YP_478676.1. NC_007776.1.

Genome annotation databases

EnsemblBacteriaiABD03413; ABD03413; CYB_2481.
GeneIDi3902474.
KEGGicyb:CYB_2481.
PATRICi23807312. VBISynSp29577_2481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000240 Genomic DNA. Translation: ABD03413.1 .
RefSeqi WP_011434040.1. NC_007776.1.
YP_478676.1. NC_007776.1.

3D structure databases

ProteinModelPortali Q2JIY1.
SMRi Q2JIY1. Positions 1-468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321332.CYB_2481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD03413 ; ABD03413 ; CYB_2481 .
GeneIDi 3902474.
KEGGi cyb:CYB_2481.
PATRICi 23807312. VBISynSp29577_2481.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
KOi K00033.
OMAi ETYQDAW.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci SSP321332:GH1B-2480-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
    Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
    ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JA-2-3B'a(2-13)Imported.

Entry informationi

Entry nameiQ2JIY1_SYNJB
AccessioniPrimary (citable) accession number: Q2JIY1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3