Q2JIN6 (Q2JIN6_SYNJB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Cobyrinic acid A,C-diamide synthase HAMAP-Rule MF_00027

Gene names

Name:	cobB HAMAP-Rule MF_00027 EMBL ABD03518.1
Ordered Locus Names:	CYB_2586

Organism

Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP] EMBL ABD03518.1

Taxonomic identifier

321332 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation By similarity. HAMAP-Rule MF_00027
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis. HAMAP-Rule MF_00027
Sequence similarities	Belongs to the CobB/CobQ family. CobB subfamily. HAMAP-Rule MF_00027 Contains 1 GATase cobBQ-type domain. HAMAP-Rule MF_00027 SAAS SAAS011698

Ontologies

Keywords
Biological process	Cobalamin biosynthesis HAMAP-Rule MF_00027 SAAS SAAS011698
Domain	Glutamine amidotransferase HAMAP-Rule MF_00027 SAAS SAAS011698
Molecular function	Ligase EMBL ABD03518.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cobalamin biosynthetic process Inferred from electronic annotation. Source: HAMAP glutamine metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	cobalamin-transporting ATPase activity Inferred from electronic annotation. Source: HAMAP cobyrinic acid a,c-diamide synthase activity Inferred from electronic annotation. Source: HAMAP ligase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Domain	263 – 450	188	GATase cobBQ-type By similarity HAMAP-Rule MF_00027
Sites
	Active site	343	1	Nucleophile By similarity HAMAP-Rule MF_00027
	Active site	442	1	By similarity HAMAP-Rule MF_00027

Sequences

	Sequence		Length	Mass (Da)
	Q2JIN6 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: A11DB3A34D3D8A6A	FASTA	470	51,432
	10 20 30 40 50 60 MAILLAAAAS GSGKTTITLA LLAALRRRGL RIQPFKVGPD YIDPLFHTAV SGIPCRNLDP 70 80 90 100 110 120 FLTDEDFVQR CFRHHCQGKD GAIVEGVMGL FDGRAPGSLP LPEGGTEPFF ASSAHVARLL 130 140 150 160 170 180 GIPVVLVIDG SGMGTTVAAL LYGLSRWDPR LSIAGVIFNR VASERHGQIL QQAAAAAGIL 190 200 210 220 230 240 VLGQFPRRED LRLPSRHLGL VPVSELDHFP HWQAAWAELA EQHVNWDSLL PLIRRLPPAV 250 260 270 280 290 300 GELWPGIPPL TERTPPRRCE QVRVAVAQDH AFNFYYADNL DLLRACGAEL LEYSPLQVGL 310 320 330 340 350 360 WPPEPCDGVL LGGGFPELFA APLSERINQQ PPPPTHPPLY AECGGLMVLG QSLTDFQGKT 370 380 390 400 410 420 YPMAGLLPIQ VDMADRLCLG YREAAVLRPT LLAPAGDRLR GHEFHRSRST PISPSPIYSW 430 440 450 460 470 GSPAQLQQEG WATERLHASY LHLHWGSRPD LAMRLLRSFI RITRGLPIPS

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000240 Genomic DNA. Translation: ABD03518.1.
RefSeq	YP_478781.1. NC_007776.1.
3D structure databases
ProteinModelPortal	Q2JIN6.
ModBase	Search...
Protein-protein interaction databases
STRING	321332.CYB_2586.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD03518; ABD03518; CYB_2586.
GeneID	3901923.
KEGG	cyb:CYB_2586.
PATRIC	23807526. VBISynSp29577_2587.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1797.
HOGENOM	HOG000289959.
KO	K02224.
OMA	CWLPGGY.
ProtClustDB	PRK01077.
Enzyme and pathway databases
UniPathway	UPA00148.
Family and domain databases
HAMAP	MF_00027. CobB.
InterPro	IPR004484. CbiA_synth. IPR017929. CobB/CobQ_GATase. IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom. IPR011698. GATase_3. [Graphical view]
Pfam	PF01656. CbiA. 1 hit. PF07685. GATase_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00379. cobB. 1 hit.
PROSITE	PS51274. GATASE_COBBQ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2JIN6_SYNJB

Accession

Primary (citable) accession number: Q2JIN6

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)