Q2JI60 (Q2JI60_SYNJB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388
EC=3.5.1.- HAMAP MF_00388

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase HAMAP MF_00388

Gene names

Name:	lpxC HAMAP MF_00388
Ordered Locus Names:	CYB_2785

Organism

Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]

Taxonomic identifier

321332 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388
Sequence similarities	Belongs to the LpxC family. HAMAP MF_00388

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00388 Lipid synthesis
Molecular function	Hydrolase HAMAP MF_00388 EMBL ABD03709.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q2JI60 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 8299D2089D4FC90D	FASTA	284	30,643
	10 20 30 40 50 60 MRGRQHTLAS SIALEGVGLH TGLPIGCSLH PAPAGSGRVF VRVDQPGSPE IPARLGSLAP 70 80 90 100 110 120 AHLCTLLQQG SPSVQVQTVE HLLAALYILG IDNCRIEVEG PELPILDGSA LPFVEAIAQA 130 140 150 160 170 180 GIQAQDQPAL LGVIQEPVTV WAGEAFVSAL PHPTARFTYG IDFADCPIGE QWLSWRENRP 190 200 210 220 230 240 DFVQSIAPAR TFARQQDVEL ARERGLIQGG SLENAIVCSQ TEWLGPLRYP DEPVRHKLID 250 260 270 280 LLGDLSLLGC RLQGHIVAYK AGHALHHRLA EQLLKSGSLL IHEE

References

[1]

"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses." Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F. ISME J. 1:703-713(2007) [PubMed: 18059494] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000240 Genomic DNA. Translation: ABD03709.1.
RefSeq	YP_478972.1. NC_007776.1.
3D structure databases
ProteinModelPortal	Q2JI60.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JI60.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3901118.
GenomeReviews	Gene locus CYB_2785 in contig CP000240_GR.
KEGG	cyb:CYB_2785.
PATRIC	23807938. VBISynSp29577_2791.
TIGR	CYB_2785.
Phylogenomic databases
eggNOG	COG0774.
HOGENOM	HBG482342.
OMA	KAYKSGH.
PhylomeDB	Q2JI60.
ProtClustDB	PRK13186.
Enzyme and pathway databases
BioCyc	SSP321332:CYB_2785-MONOMER.
Family and domain databases
HAMAP	MF_00388. LpxC. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KO	K02535.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. LpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q2JI60_SYNJB

Accession

Primary (citable) accession number: Q2JI60

Entry history

Integrated into UniProtKB/TrEMBL:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)