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Q2JHZ4 (HEMH_SYNJB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:CYB_2857
OrganismSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) [Complete proteome] [HAMAP]
Taxonomic identifier321332 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP-Rule MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP-Rule MF_00323

Pathway

Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Ferrochelatase HAMAP-Rule MF_00323
PRO_1000019376

Sites

Metal binding1961Iron By similarity
Metal binding2771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2JHZ4 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 8F713E926EB94860

FASTA34438,612
        10         20         30         40         50         60 
MSKSGVLLLN LGGPETQADV QPFLYNLFAD PELIRLPFPF LQRAFAWAIS TLRAEKSRRN 

        70         80         90        100        110        120 
YAAIGGGSPL RRITAEQARE LQAHLVAEGY DVPVYVAMRY WHPLIESVVQ QIKSDGITRL 

       130        140        150        160        170        180 
VVLPLYPQYS ISTTGSSFKL LDRLWAEDPE LACIERRQIC SWYDQPQYVQ AMARAIREQL 

       190        200        210        220        230        240 
DGFAEPEGVH VLFSAHGIPE SYVTEAGDPY QREMEACVRL IWKQVGRPND HTLSYQSRVG 

       250        260        270        280        290        300 
SVRWLQPYTE RVILELGSRG VKQLLVVPIS FVSEHIETLQ EIDIEYRELA HRAGIADFRR 

       310        320        330        340 
VPALNADPLF IAGLAALVRP HLLTPGLAAP AFVPAAVGSS LLER

« Hide

References

[1]"Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JA-2-3B'a(2-13).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000240 Genomic DNA. Translation: ABD03777.1.
RefSeqYP_479040.1. NC_007776.1.

3D structure databases

ProteinModelPortalQ2JHZ4.
ModBaseSearch...

Protein-protein interaction databases

STRING321332.CYB_2857.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD03777; ABD03777; CYB_2857.
GeneID3900713.
KEGGcyb:CYB_2857.
PATRIC23808082. VBISynSp29577_2862.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHOG000060727.
KOK01772.
OMAWNNSSEV.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycSSP321332:GH1B-2857-MONOMER.
UniPathwayUPA00252; UER00325.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERPTHR11108. PTHR11108. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. hemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_SYNJB
AccessionPrimary (citable) accession number: Q2JHZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: May 29, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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