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Q2JHX0

- SYL_SYNJB

UniProt

Q2JHX0 - SYL_SYNJB

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei635 – 6351ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP321332:GH1B-2881-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CYB_2881
OrganismiSynechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime)
Taxonomic identifieri321332 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001938: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 882882Leucine--tRNA ligasePRO_1000009456Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321332.CYB_2881.

Structurei

3D structure databases

ProteinModelPortaliQ2JHX0.
SMRiQ2JHX0. Positions 4-818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi632 – 6365"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVHRQSWP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JHX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDARYNPQAI ESKWQAHWRE IGLDRTPELK DGSRKFYALS MFPYPSGNLH
60 70 80 90 100
MGHVRNYTIT DVIARHKRMQ GYAVLHPMGW DAFGLPAENA AIDRGIPPAK
110 120 130 140 150
WTYQNIAQMR EQLQRLGLSY DWEREITTCA PDYYKWTQWL FLQFFKAGLA
160 170 180 190 200
YQKEAPVNWD PVDQTVLANE QVDAEGRSWR SGALVEKRML KQWFFKITAY
210 220 230 240 250
ADQLLADLEK LSGWPERVRT MQENWIGQSV GAKVIFKTEA GDELAVFTTR
260 270 280 290 300
PDTLWGATFM VMSPEHPLVD KLTTAEQLQA VRAYQAQAAA RSEIERSAED
310 320 330 340 350
REKTGVWTGS YAINPVNQER IPIWIADYVL MGYGTGAIMA VPAHDQRDFE
360 370 380 390 400
FARKFGLPIK RVVQPPEGSL SSTDRASGTE SSELQAAWTG EGVMINSGPL
410 420 430 440 450
DGIPVGKGPG QSVERAIAWL EAQGLGEKQI NYRLRDWLIS RQRYWGCPIP
460 470 480 490 500
VIHCPHCGIV PVPEKDLPVL LPEDVELTGR GGSPLAQLED WVKVKCPTCG
510 520 530 540 550
AEARRETDTM DTFICSSWYF LRFSDARNDR EIFRKDRVNA WLPVDQYVGG
560 570 580 590 600
IEHAILHLLY SRFFTKVLRD RGLLDFDEPF LRLLTQGMVQ GRTYYNPNKS
610 620 630 640 650
GKDRWIPAAL VKDPDNPTDP ETGEPLEVIY ATMSKSKGNG VDPEEVLAHY
660 670 680 690 700
GADTARMFIL FKAPPEKDLE WDDADVEGQF RFLNRVWRQV YEFVVRGGGT
710 720 730 740 750
ESWRGRVSEL LPAKVEVGSL TKAEKDLRRA IHTAIKEVSE DLENDYQFNT
760 770 780 790 800
AIAELMKLSN ALGEAGIPDS PVYAEGIRTL VLLMAPFAPH IAEELWQALG
810 820 830 840 850
GADSVHRQSW PSYDPAALVA DTVTIVIQVN GKLRGSFEAP AEVTPEEQEQ
860 870 880
LALRSEAAQK YLEGATPKKV VVVPKKLVNF VL
Length:882
Mass (Da):99,521
Last modified:March 7, 2006 - v1
Checksum:i6ED220A8B591A861
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000240 Genomic DNA. Translation: ABD03801.1.
RefSeqiWP_011434420.1. NC_007776.1.
YP_479064.1. NC_007776.1.

Genome annotation databases

EnsemblBacteriaiABD03801; ABD03801; CYB_2881.
GeneIDi3900583.
KEGGicyb:CYB_2881.
PATRICi23808132. VBISynSp29577_2887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000240 Genomic DNA. Translation: ABD03801.1 .
RefSeqi WP_011434420.1. NC_007776.1.
YP_479064.1. NC_007776.1.

3D structure databases

ProteinModelPortali Q2JHX0.
SMRi Q2JHX0. Positions 4-818.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321332.CYB_2881.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD03801 ; ABD03801 ; CYB_2881 .
GeneIDi 3900583.
KEGGi cyb:CYB_2881.
PATRICi 23808132. VBISynSp29577_2887.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VHRQSWP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SSP321332:GH1B-2881-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Population level functional diversity in a microbial community revealed by comparative genomic and metagenomic analyses."
    Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N., Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.
    ISME J. 1:703-713(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JA-2-3B'a(2-13).

Entry informationi

Entry nameiSYL_SYNJB
AccessioniPrimary (citable) accession number: Q2JHX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3