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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei301D-inositol 3-phosphateUniRule annotation1
Binding sitei44UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei991D-inositol 3-phosphateUniRule annotation1
Binding sitei1321D-inositol 3-phosphateUniRule annotation1
Binding sitei1561D-inositol 3-phosphateUniRule annotation1
Binding sitei1761D-inositol 3-phosphateUniRule annotation1
Binding sitei250UDP-GlcNAcUniRule annotation1
Binding sitei255UDP-GlcNAcUniRule annotation1
Metal bindingi325Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi326Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi328Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei338UDP-GlcNAcUniRule annotation1
Binding sitei346UDP-GlcNAcUniRule annotation1
Metal bindingi352MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Metal-binding

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Francci3_0456
OrganismiFrankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000001937 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001231 – 435D-inositol 3-phosphate glycosyltransferaseAdd BLAST435

Proteomic databases

PRIDEiQ2JFV0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi106370.Francci3_0456

Structurei

3D structure databases

ProteinModelPortaliQ2JFV0
SMRiQ2JFV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 37UDP-GlcNAc bindingUniRule annotation2
Regioni41 – 461D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M Bacteria
COG0438 LUCA
HOGENOMiHOG000077288
KOiK15521
OMAiHTMAKVK
OrthoDBiPOG091H0AO3

Family and domain databases

HAMAPiMF_01695 MshA, 1 hit
InterProiView protein in InterPro
IPR001296 Glyco_trans_1
IPR028098 Glyco_trans_4-like_N
IPR017814 Mycothiol_biosynthesis_MshA
PfamiView protein in Pfam
PF13439 Glyco_transf_4, 1 hit
PF00534 Glycos_transf_1, 1 hit
TIGRFAMsiTIGR03449 mycothiol_MshA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2JFV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIRSGAAQ VRGEAERRGR PSRVAMLSMH TSPMEQPGTG DAGGLNVYVV
60 70 80 90 100
ELSRQLAALG VEVEVFTRAV SSKLPTSAEL LPGVTVRHVD AGPFEEIHRE
110 120 130 140 150
DLPAWLCAFT AALLRAEAGH EPGWFDVIHS HYWLSGQVGL AVAQRWGIPL
160 170 180 190 200
VHTSHTLAKI KNGALAVGDR PEPPGRLLGE QEVIGGATRL LASTPDEYRH
210 220 230 240 250
LIDLYDAASD RVDVVAPGVD LEVFRPGDMA QSRARVGVDP ADDLLLFVGR
260 270 280 290 300
IQPLKAPDLL LRAAAELLRR DPARRSRLTV AVVGGPSGSG LEQPDALVKL
310 320 330 340 350
AAYLGISDRV RFQPPAPQQE LVHWYRAATA VVVPSHSESF GLVALEAQAC
360 370 380 390 400
GTPVVAAAVG GLRTAVADGV SGLLVSGRTP AVYADALDRL LRQPRWRARL
410 420 430
SAGAVAWAGG FGWSATAHGV LRSYRHALSP TAVAV
Length:435
Mass (Da):46,275
Last modified:March 7, 2006 - v1
Checksum:i2D226ED3F72607A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA Translation: ABD09842.1
RefSeqiWP_011434919.1, NC_007777.1

Genome annotation databases

EnsemblBacteriaiABD09842; ABD09842; Francci3_0456
GeneIDi32155463
KEGGifra:Francci3_0456

Similar proteinsi

Entry informationi

Entry nameiMSHA_FRACC
AccessioniPrimary (citable) accession number: Q2JFV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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