Q2JFM8 (FENR_FRASC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferredoxin--NADP reductase
Short name=FNR
Short name=Fd-NADP+ reductase
EC=1.18.1.2

Gene names

Ordered Locus Names:

Francci3_0530

Organism

Frankia sp. (strain CcI3) [Complete proteome] [HAMAP]

Taxonomic identifier

106370 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP MF_01685
Cofactor	Binds 1 FAD per subunit By similarity. HAMAP MF_01685
Subunit structure	Homodimer By similarity. HAMAP MF_01685
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Ferredoxin--NADP reductase HAMAP MF_01685		PRO_0000364839
Sites
	Binding site	28	1	FAD By similarity
	Binding site	36	1	FAD By similarity
	Binding site	41	1	FAD By similarity
	Binding site	81	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	115	1	FAD; via amide nitrogen By similarity
	Binding site	274	1	FAD By similarity
	Binding site	315	1	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2JFM8 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: AE7E778C0B149B5E	FASTA	321	34,028
	10 20 30 40 50 60 MLIVGAGPAG LYGAYYAGFR GMSVALMDSL PEAGGQVTAM YPEKVIYDIA GLPAVRGREL 70 80 90 100 110 120 IDALLIQANQ FSPTYLLGQQ AAELAHKPDA VVVTSSQGLR VRAKVVVITG GLGTFAPRPL 130 140 150 160 170 180 PTGTAHLGRG LVYFVPKLDV HTGQDVIVVG GGDSAFDWAL ALEPIARSVT LVHRRDRFRA 190 200 210 220 230 240 HMSTVERVEA SSVEILTFTE VAMVHGEEWI EKVELVQTRT GDRHVRPAQA VVAALGFTAD 250 260 270 280 290 300 LGPLTRWNLT IDKRHIVVDP TMATGVERIF AAGDITEYPG KVRLIATGFG EAATAVNNAA 310 320 PLVDPSAKIF PGHSSDDGTG G

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CcI3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000249 Genomic DNA. Translation: ABD09914.1.
RefSeq	YP_479643.1. NC_007777.1.
3D structure databases
ProteinModelPortal	Q2JFM8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JFM8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3905441.
GenomeReviews	Gene locus Francci3_0530 in contig CP000249_GR.
KEGG	fra:Francci3_0530.
PATRIC	21923908. VBIFraSp10456_0583.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0492.
HOGENOM	HBG669726.
OMA	GRGLVYF.
ProtClustDB	CLSK947807.
Enzyme and pathway databases
BioCyc	FSP106370:FRANCCI3_0530-MONOMER.
Family and domain databases
HAMAP	MF_01685. FENR2. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR022890. Fd--NADP_Rdtase_type_2. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
KO	K00384.
PANTHER	PTHR22912:SF53. PTHR22912:SF53. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
ProtoNet	Search...

Entry information

Entry name

FENR_FRASC

Accession

Primary (citable) accession number: Q2JFM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program