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Q2JFJ9 (Q2JFJ9_FRASC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:Francci3_0559
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP] EMBL ABD09943.1
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region115 – 12395-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site2415-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site8915-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9015-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9315-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1191Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
Q2JFJ9 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 307B82706DADE2A9

FASTA17818,742
        10         20         30         40         50         60 
MNDNAALAAQ VRTASQLTGT FLLRSGRTST EYFDKYLFEA DPALLAAVVA GLTELVPPGA 

        70         80         90        100        110        120 
EILAGLELGG VPLVTLLSQR TGLPARFVRK KAKEYGTRRI AEGGDVTGRH VALVEDVVTS 

       130        140        150        160        170 
GGAVLDATRV LRDAGAVVEH VLCVIDRQEG GRERLAELGL TLHPVLTRAD LEAAAADT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000249 Genomic DNA. Translation: ABD09943.1.
RefSeqYP_479672.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2JFJ9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2JFJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3905780.
GenomeReviewsGene locus Francci3_0559 in contig CP000249_GR.
KEGGfra:Francci3_0559.
PATRIC21923974. VBIFraSp10456_0615.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMAEMGGIPI.
PhylomeDBQ2JFJ9.
ProtClustDBCLSK2486794.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2JFJ9_FRASC
AccessionPrimary (citable) accession number: Q2JFJ9
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info