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Q2JFD6 (ALR_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:Francci3_0622
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Alanine racemase HAMAP-Rule MF_01201
PRO_1000065989

Sites

Active site461Proton acceptor; specific for D-alanine By similarity
Active site2781Proton acceptor; specific for L-alanine By similarity
Binding site1441Substrate By similarity
Binding site3261Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue461N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2JFD6 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 037FD75C7602E435

FASTA38439,581
        10         20         30         40         50         60 
MTEQRAGSPA GNDLRSCAVI DLDAVRTSVT ALVARAGDAA TMAVVKADGY GHGMIPCARA 

        70         80         90        100        110        120 
ALEGGATWLG TAFLEEALAL RAAGFTVPVL SWLAAPGESF AAAIAADVDL SASAGWALEE 

       130        140        150        160        170        180 
AAAAARRTGR TARVHLKADT GLGRAGATEA DWPALCDAGA ALEAEGVIEV IGVWSHFAFA 

       190        200        210        220        230        240 
DAPGHPTVQG QIGRFRDAID IATKAGLHPS VRHLANSAAT LVSPEAHFDL VRPGVSVYGL 

       250        260        270        280        290        300 
SPGPEIGPPA AFGLRPAMTL TTHAALTKRV PAGTGVSYAH RYTTTRETTL AVVPLGYADG 

       310        320        330        340        350        360 
IPRSATNTAE VLFGGRRRRI AGTVCMDQFV LDVGDDQVAA GDEVLLFGPG DRGEPTADDW 

       370        380 
AAALGTINYE IVSRVGARVP RRYV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD10006.1.
RefSeqYP_479735.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2JFD6.
SMRQ2JFD6. Positions 15-384.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_0622.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD10006; ABD10006; Francci3_0622.
GeneID3903490.
KEGGfra:Francci3_0622.
PATRIC21924112. VBIFraSp10456_0681.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMAITMDQLM.
OrthoDBEOG6PP9NJ.
ProtClustDBCLSK947836.

Enzyme and pathway databases

BioCycFSP106370:GI1F-639-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_FRASC
AccessionPrimary (citable) accession number: Q2JFD6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways