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Protein

Urease subunit alpha

Gene

ureC

Organism
Frankia sp. (strain CcI3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC), Urease subunit beta (ureB), Urease subunit gamma (ureA)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi143 – 1431Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi145 – 1451Nickel 1; via tele nitrogenUniRule annotation
Metal bindingi226 – 2261Nickel 1; via carbamate groupUniRule annotation
Metal bindingi226 – 2261Nickel 2; via carbamate groupUniRule annotation
Binding sitei228 – 2281SubstrateUniRule annotation
Metal bindingi255 – 2551Nickel 2; via pros nitrogenUniRule annotation
Metal bindingi281 – 2811Nickel 2; via tele nitrogenUniRule annotation
Active sitei329 – 3291Proton donorUniRule annotation
Metal bindingi369 – 3691Nickel 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciFSP106370:GI1F-849-MONOMER.
UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:Francci3_0832
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000001937 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Urease subunit alphaPRO_0000239875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi106370.Francci3_0832.

Structurei

3D structure databases

ProteinModelPortaliQ2JES6.
SMRiQ2JES6. Positions 2-575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 575438UreaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the urease family.UniRule annotation
Contains 1 urease domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.
OMAiFDSHIHF.
OrthoDBiPOG091H0ARR.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JES6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLDRSRYA ALYGPTVGDR IRLADTDLFI EVTEDRSRGP AGTGTGDEAV
60 70 80 90 100
FGGGKVIRES MGQSLATRAE GAPDLVITGA VVLDHWGVVK ADVGIRDGRI
110 120 130 140 150
VALGKAGNPD TMDGVHPELV MGPGTEIIAG NGKILTAGAV DCHVHLICPQ
160 170 180 190 200
QVPEALGAGI TTLIGGGTGP AEGTKATTVT PGSWNLARML SALDDWPVNV
210 220 230 240 250
VLLGKGNTVS DESMWEQLRA GAAGFKLHED WGTTPAAIDA CLRVADAAGV
260 270 280 290 300
QVALHSDTLN EAGFVEDTLA AIAGRAIHAY HTEGAGGGHA PDIITVAAAG
310 320 330 340 350
NVLPSSTNPT RPHTVNTLDE HLDMLMVCHH LNPSVPEDLA FAESRIRPST
360 370 380 390 400
IAAEDILHDL GAISMIGSDS QAMGRIGEVV LRTWQTAHVM KLRRGSLAGD
410 420 430 440 450
DRADNTRARR YIAKYTICPA VAHGLDAEIG SVEPGKLADL VLYDPAFFGV
460 470 480 490 500
RPSLVLKGGF IAWAAMGDAN ASIPTPQPVL PRPMWGAARG PAAASSLIFV
510 520 530 540 550
APAAIEDGLP GRLGLATPVV PVADVRRRGK ADLPENTATP DIRVDPDTFT
560 570
VTVDGEAIEA DPVSELPMTQ RYFLF
Length:575
Mass (Da):60,100
Last modified:March 7, 2006 - v1
Checksum:i94389AA0821A0C59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD10216.1.
RefSeqiWP_011435285.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD10216; ABD10216; Francci3_0832.
KEGGifra:Francci3_0832.
PATRICi21924576. VBIFraSp10456_0914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD10216.1.
RefSeqiWP_011435285.1. NC_007777.1.

3D structure databases

ProteinModelPortaliQ2JES6.
SMRiQ2JES6. Positions 2-575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi106370.Francci3_0832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD10216; ABD10216; Francci3_0832.
KEGGifra:Francci3_0832.
PATRICi21924576. VBIFraSp10456_0914.

Phylogenomic databases

eggNOGiENOG4105CQM. Bacteria.
COG0804. LUCA.
HOGENOMiHOG000075064.
KOiK01428.
OMAiFDSHIHF.
OrthoDBiPOG091H0ARR.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.
BioCyciFSP106370:GI1F-849-MONOMER.

Family and domain databases

CDDicd00375. Urease_alpha. 1 hit.
Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01953. Urease_alpha. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
IPR011612. Urease_alpha_N_dom.
IPR017950. Urease_AS.
IPR005848. Urease_asu.
IPR017951. Urease_asu_c.
IPR029754. Urease_Ni-bd.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00449. Urease_alpha. 1 hit.
[Graphical view]
PRINTSiPR01752. UREASE.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 2 hits.
TIGRFAMsiTIGR01792. urease_alph. 1 hit.
PROSITEiPS01120. UREASE_1. 1 hit.
PS00145. UREASE_2. 1 hit.
PS51368. UREASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURE1_FRASC
AccessioniPrimary (citable) accession number: Q2JES6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.