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Q2JDQ9

- CLPP1_FRASC

UniProt

Q2JDQ9 - CLPP1_FRASC

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Protein
ATP-dependent Clp protease proteolytic subunit 1
Gene
clpP1, Francci3_1205
Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Nucleophile By similarity
Active sitei133 – 1331 By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciFSP106370:GI1F-1229-MONOMER.

Protein family/group databases

MEROPSiS14.008.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit 1 (EC:3.4.21.92)
Alternative name(s):
Endopeptidase Clp 1
Gene namesi
Name:clpP1
Ordered Locus Names:Francci3_1205
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213ATP-dependent Clp protease proteolytic subunit 1UniRule annotation
PRO_0000236387Add
BLAST

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Protein-protein interaction databases

STRINGi106370.Francci3_1205.

Structurei

3D structure databases

ProteinModelPortaliQ2JDQ9.
SMRiQ2JDQ9. Positions 25-203.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.

Phylogenomic databases

eggNOGiCOG0740.
HOGENOMiHOG000285833.
KOiK01358.
OMAiADITIQA.
OrthoDBiEOG6Z3KQ0.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JDQ9-1 [UniParc]FASTAAdd to Basket

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MSNIAAPRLP VPGPDLRAPG QGGPAFDDQV FNRLLANRIV FLGSVVEDSI    50
ANAICAQLLL LNAEDPTRDI FLYINSPGGS VSAGMAIYDT MQFVENDVAT 100
VSLGLAASMG QFLLCAGASG KRYSLPHARI MMHQPSGGIG GTASDIAIQA 150
EQMLYTKRMM QERIAFHTGQ PIEQIERDSD RDRWFTAEEA KDYGFVDHVV 200
QQARQVPSEG PVS 213
Length:213
Mass (Da):23,039
Last modified:March 7, 2006 - v1
Checksum:iA96C99EFFAB03FAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD10583.1.
RefSeqiYP_480312.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD10583; ABD10583; Francci3_1205.
GeneIDi3903559.
KEGGifra:Francci3_1205.
PATRICi21925372. VBIFraSp10456_1306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD10583.1 .
RefSeqi YP_480312.1. NC_007777.1.

3D structure databases

ProteinModelPortali Q2JDQ9.
SMRi Q2JDQ9. Positions 25-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 106370.Francci3_1205.

Protein family/group databases

MEROPSi S14.008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD10583 ; ABD10583 ; Francci3_1205 .
GeneIDi 3903559.
KEGGi fra:Francci3_1205.
PATRICi 21925372. VBIFraSp10456_1306.

Phylogenomic databases

eggNOGi COG0740.
HOGENOMi HOG000285833.
KOi K01358.
OMAi ADITIQA.
OrthoDBi EOG6Z3KQ0.

Enzyme and pathway databases

BioCyci FSP106370:GI1F-1229-MONOMER.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3.

Entry informationi

Entry nameiCLPP1_FRASC
AccessioniPrimary (citable) accession number: Q2JDQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 7, 2006
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi