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Q2JDQ9 (CLPP1_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease proteolytic subunit 1

EC=3.4.21.92
Alternative name(s):
Endopeptidase Clp 1
Gene names
Name:clpP1
Ordered Locus Names:Francci3_1205
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP-Rule MF_00444

Catalytic activity

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP-Rule MF_00444

Subunit structure

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00444.

Sequence similarities

Belongs to the peptidase S14 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213ATP-dependent Clp protease proteolytic subunit 1 HAMAP-Rule MF_00444
PRO_0000236387

Sites

Active site1081Nucleophile By similarity
Active site1331 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2JDQ9 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: A96C99EFFAB03FAB

FASTA21323,039
        10         20         30         40         50         60 
MSNIAAPRLP VPGPDLRAPG QGGPAFDDQV FNRLLANRIV FLGSVVEDSI ANAICAQLLL 

        70         80         90        100        110        120 
LNAEDPTRDI FLYINSPGGS VSAGMAIYDT MQFVENDVAT VSLGLAASMG QFLLCAGASG 

       130        140        150        160        170        180 
KRYSLPHARI MMHQPSGGIG GTASDIAIQA EQMLYTKRMM QERIAFHTGQ PIEQIERDSD 

       190        200        210 
RDRWFTAEEA KDYGFVDHVV QQARQVPSEG PVS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD10583.1.
RefSeqYP_480312.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2JDQ9.
SMRQ2JDQ9. Positions 25-203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_1205.

Protein family/group databases

MEROPSS14.008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD10583; ABD10583; Francci3_1205.
GeneID3903559.
KEGGfra:Francci3_1205.
PATRIC21925372. VBIFraSp10456_1306.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0740.
HOGENOMHOG000285833.
KOK01358.
OMAADITIQA.
OrthoDBEOG6Z3KQ0.

Enzyme and pathway databases

BioCycFSP106370:GI1F-1229-MONOMER.

Family and domain databases

Gene3D3.90.226.10. 1 hit.
HAMAPMF_00444. ClpP.
InterProIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERPTHR10381. PTHR10381. 1 hit.
PfamPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSPR00127. CLPPROTEASEP.
SUPFAMSSF52096. SSF52096. 1 hit.
PROSITEPS00382. CLP_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLPP1_FRASC
AccessionPrimary (citable) accession number: Q2JDQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 7, 2006
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries