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Q2JDD9 (DXS_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:Francci3_1326
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6556551-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
PRO_0000256418

Sequences

Sequence LengthMass (Da)Tools
Q2JDD9 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 2197EBFB348B64D4

FASTA65569,593
        10         20         30         40         50         60 
MSLLSTISSP QDVKRLDHEE LATLAAEIRD FLIHAVARTG GHLGPNLGAV ELTLAIHRVF 

        70         80         90        100        110        120 
DSPFDRILWD TGHQSYVHKI LTGRADDFSG LRQRGGLSGY PSRAESEHDI IENSHASTAL 

       130        140        150        160        170        180 
SYADGLSRAY ALRGEDRAVV AVVGDGALTG GMCWEALNNI AADDRPVVIV VNDNGRSYAP 

       190        200        210        220        230        240 
TIGGLADHLA ALRLAPEYEQ VLDVVKQVLG RTPLVGPPLF DALHGIKKGI KDVVQPQGMF 

       250        260        270        280        290        300 
EDLGLKYVGP VDGHDVVAVE SALRRARDFG GPVIVHCVTR KGFGYPPAEQ DDADNFHGVG 

       310        320        330        340        350        360 
IIDPATGKPV STSKTISWTS IFSDEIVQIG SERPDVVTLT AAMLQPVGLG AFAKAYPDRV 

       370        380        390        400        410        420 
FDVGIAEQHA VTSAAGLAMG GLKPVVCLYA TFLNRAFDQV LMDVALHRQP VTFVLDRAGI 

       430        440        450        460        470        480 
TGEDGASHNG MWDLSFLQVV PGLAIAAPRD APTLRAELRE AVGDTDGPTV VRFPKGKVAV 

       490        500        510        520        530        540 
DVPAIDTVGG VDVLYRSPKV AQRREVLLVS IGAMAATCLE VAERVASQGI GITVVDPRWV 

       550        560        570        580        590        600 
KPLDPALIDL ARAHDLVVTV EDNGRVGGVG AALAQLLRDA DVDVPLRDFG IAQRFLDHGK 

       610        620        630        640        650 
RDEVMAEVGL APQDLARKVV EAVAKRQPAI EDDPTSPGEA APAGERAGEA IGDQR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000249 Genomic DNA. Translation: ABD10703.1.
RefSeqYP_480432.1. NC_007777.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2JDD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3906598.
GenomeReviewsGene locus Francci3_1326 in contig CP000249_GR.
KEGGfra:Francci3_1326.
PATRIC21925636. VBIFraSp10456_1437.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMADPILYHG.
PhylomeDBQ2JDD9.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycFSP106370:FRANCCI3_1326-MONOMER.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_FRASC
AccessionPrimary (citable) accession number: Q2JDD9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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