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Protein

Catalase-peroxidase

Gene

katG

Organism
Frankia sp. (strain CcI3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei105 – 1051Transition state stabilizerUniRule annotation
Active sitei109 – 1091Proton acceptorUniRule annotation
Metal bindingi272 – 2721Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciFSP106370:GI1F-1950-MONOMER.

Protein family/group databases

PeroxiBasei2368. FspCP_CcI3.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Francci3_1918
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000001937 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Catalase-peroxidasePRO_0000354797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki108 ↔ 231Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-257)UniRule annotation
Cross-linki231 ↔ 257Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-108)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi106370.Francci3_1918.

Structurei

3D structure databases

ProteinModelPortaliQ2JBP8.
SMRiQ2JBP8. Positions 33-743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JBP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENHDAVVY NTNAENGGGC PVAHRRAPHP TQGGGNRGWW PNRLNLKILA
60 70 80 90 100
KNPAVANPLG GEFTYAEAFR TLDLAAVKQD IAAVLTTSQA WWPADYGHYG
110 120 130 140 150
PFIIRMAWHS AGTYRISDGR GGAGAGQLRF APLNSWPDNA NLDKARRLLW
160 170 180 190 200
PVKKKYGQKI SWADLMILAG NVALESMGFE TFGFAGGRVD VWEPDEDVYW
210 220 230 240 250
GPETTWLDDE RYTGDRELEN PLAAVQMGLI YVNPEGPNGN PDPIAAARDI
260 270 280 290 300
RETFRRMAMN DEETVALIAG GHTFGKTHGA ANPDEHVGPE PEGAPIEEQG
310 320 330 340 350
FGWTSTFGTG RGGDTITSGL EGAWTNTPVS WDNSFFEILF SYEWELTKSP
360 370 380 390 400
AGANQWKPKD GAGAGTVPDA HDAAKSHAPT MLTTDLALRF DPIYEPISRR
410 420 430 440 450
FLENPSAFAD AFARAWFKLT HRDLGPVARY LGPEVPTETL LWQDPLPAVA
460 470 480 490 500
HELIDAADVA TLKGQILASG LSVSQLVSTA WASASTFRGG DKRGGANGAR
510 520 530 540 550
IRLEPQRGWE VNEPDQLAAV LRTLTRIQEV FNAAQTGGKQ VSLADLIVLA
560 570 580 590 600
GGVAVEQAAA NAGFDVEVPF APGRTDASQE QTDVESFAVL EPTADGFRNY
610 620 630 640 650
LGKGHRLPAE YLLLDRANQL TLSAPELTVL VGGLRVLGAN YQQSPLGVFT
660 670 680 690 700
ATPGSLTNDF FVNLLELGTT WKTTSEDANT FEGRDAATGK VRWTGSRADL
710 720 730 740
VFGSNSELRA LAEVYASDDA REKFVHDFVA AWVKVMNLDR FDLV
Length:744
Mass (Da):80,679
Last modified:March 7, 2006 - v1
Checksum:i0E7E7C028A9DC4FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD11294.1.
RefSeqiWP_011436354.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD11294; ABD11294; Francci3_1918.
KEGGifra:Francci3_1918.
PATRICi21926916. VBIFraSp10456_2071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD11294.1.
RefSeqiWP_011436354.1. NC_007777.1.

3D structure databases

ProteinModelPortaliQ2JBP8.
SMRiQ2JBP8. Positions 33-743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi106370.Francci3_1918.

Protein family/group databases

PeroxiBasei2368. FspCP_CcI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD11294; ABD11294; Francci3_1918.
KEGGifra:Francci3_1918.
PATRICi21926916. VBIFraSp10456_2071.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciFSP106370:GI1F-1950-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3.

Entry informationi

Entry nameiKATG_FRASC
AccessioniPrimary (citable) accession number: Q2JBP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 7, 2006
Last modified: December 9, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.