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Q2JAX0

- Q2JAX0_FRASC

UniProt

Q2JAX0 - Q2JAX0_FRASC

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Francci3_2203

Organism
Frankia sp. (strain CcI3)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei145 – 1451SubstrateUniRule annotation
    Sitei255 – 2551Critical for catalysisUniRule annotation
    Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
    Sitei418 – 4181Critical for catalysisUniRule annotation
    Binding sitei545 – 5451Substrate
    Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciFSP106370:GI1F-2236-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    Ordered Locus Names:Francci3_2203Imported
    OrganismiFrankia sp. (strain CcI3)Imported
    Taxonomic identifieri106370 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
    ProteomesiUP000001937: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi106370.Francci3_2203.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2JAX0.
    SMRiQ2JAX0. Positions 4-738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni132 – 1398Substrate binding

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiSIVKLMQ.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2JAX0-1 [UniParc]FASTAAdd to Basket

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    MTDSTIIYTH TDEAPALATY SFLPVVQAYA ATAGVSVDSR DISLAGRIIA    50
    SFPEDLEEAQ RIEDALAELG ELARTPEANI IKLPNISASI PQLKAAIVEL 100
    QKRGYALPDY PDDPKTDEER EIRARYDKVK GSAVNPVLRE GNSDRRAPAS 150
    VKNYARTHPH RMGAWTPDSK TNVATMGAGD FRSTEKSTII AAAGTLRIEL 200
    AGDDGSTTVL LPSLPVLAGE VVDAAVLRVA ALREFLTAQI ARAKAEGVLF 250
    SVHLKATMMK VSDPIIFGHV VRAFFPKTFA THGATLAAAG LSPNDGLGGI 300
    LKGLESLPEG AQIKASFAAE LAEGPALAMV DSDRGITNLH VPSDVIVDAS 350
    MPAMIRTSGH MWGPDGREAD TLAVLPDSSY AGIYQVAIDD CRAHGAYDPA 400
    TMGSVANVGL MAQKAEEYGS HDKTFEIPTT GTVRIVDQAG TVVLEQAVAA 450
    GDIFRACQTK DAPIRDWVKL AVARARATGD PAVFWLDENR AHDARLIEKV 500
    RAYLPGHDTS GLRIEIKAPV DAIAFSLERI RRGENTISVT GNVLRDYLTD 550
    LFPILELGTS AKMLSIVPLM NGGGLFETGA GGSAPKHVQQ LLRENYLRWD 600
    SLGEFLALAA SFEQFARTTG NARAQVLADT LDRATATFLN EDKSPSRRLG 650
    GLDNRGSHFY LALYWAQELA AQIGDPRLAE AFAGLAKTLA DQEKAIVDEL 700
    IAVQGSPADI GGYYQPDPVK AAAVMRPSKI FNEAIASLG 739
    Length:739
    Mass (Da):78,945
    Last modified:March 7, 2006 - v1
    Checksum:i3FB68196C50F95F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD11572.1.
    RefSeqiWP_011436619.1. NC_007777.1.
    YP_481301.1. NC_007777.1.

    Genome annotation databases

    EnsemblBacteriaiABD11572; ABD11572; Francci3_2203.
    GeneIDi3906342.
    KEGGifra:Francci3_2203.
    PATRICi21927560. VBIFraSp10456_2393.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD11572.1 .
    RefSeqi WP_011436619.1. NC_007777.1.
    YP_481301.1. NC_007777.1.

    3D structure databases

    ProteinModelPortali Q2JAX0.
    SMRi Q2JAX0. Positions 4-738.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 106370.Francci3_2203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD11572 ; ABD11572 ; Francci3_2203 .
    GeneIDi 3906342.
    KEGGi fra:Francci3_2203.
    PATRICi 21927560. VBIFraSp10456_2393.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi SIVKLMQ.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci FSP106370:GI1F-2236-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CcI3Imported.

    Entry informationi

    Entry nameiQ2JAX0_FRASC
    AccessioniPrimary (citable) accession number: Q2JAX0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3