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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Francci3_2203

Organism
Frankia sp. (strain CcI3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451SubstrateUniRule annotation
Sitei255 – 2551Critical for catalysisUniRule annotation
Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
Sitei418 – 4181Critical for catalysisUniRule annotation
Binding sitei545 – 5451SubstrateUniRule annotation
Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFSP106370:GI1F-2236-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Francci3_2203Imported
OrganismiFrankia sp. (strain CcI3)Imported
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi106370.Francci3_2203.

Structurei

3D structure databases

ProteinModelPortaliQ2JAX0.
SMRiQ2JAX0. Positions 4-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1398Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2JAX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSTIIYTH TDEAPALATY SFLPVVQAYA ATAGVSVDSR DISLAGRIIA
60 70 80 90 100
SFPEDLEEAQ RIEDALAELG ELARTPEANI IKLPNISASI PQLKAAIVEL
110 120 130 140 150
QKRGYALPDY PDDPKTDEER EIRARYDKVK GSAVNPVLRE GNSDRRAPAS
160 170 180 190 200
VKNYARTHPH RMGAWTPDSK TNVATMGAGD FRSTEKSTII AAAGTLRIEL
210 220 230 240 250
AGDDGSTTVL LPSLPVLAGE VVDAAVLRVA ALREFLTAQI ARAKAEGVLF
260 270 280 290 300
SVHLKATMMK VSDPIIFGHV VRAFFPKTFA THGATLAAAG LSPNDGLGGI
310 320 330 340 350
LKGLESLPEG AQIKASFAAE LAEGPALAMV DSDRGITNLH VPSDVIVDAS
360 370 380 390 400
MPAMIRTSGH MWGPDGREAD TLAVLPDSSY AGIYQVAIDD CRAHGAYDPA
410 420 430 440 450
TMGSVANVGL MAQKAEEYGS HDKTFEIPTT GTVRIVDQAG TVVLEQAVAA
460 470 480 490 500
GDIFRACQTK DAPIRDWVKL AVARARATGD PAVFWLDENR AHDARLIEKV
510 520 530 540 550
RAYLPGHDTS GLRIEIKAPV DAIAFSLERI RRGENTISVT GNVLRDYLTD
560 570 580 590 600
LFPILELGTS AKMLSIVPLM NGGGLFETGA GGSAPKHVQQ LLRENYLRWD
610 620 630 640 650
SLGEFLALAA SFEQFARTTG NARAQVLADT LDRATATFLN EDKSPSRRLG
660 670 680 690 700
GLDNRGSHFY LALYWAQELA AQIGDPRLAE AFAGLAKTLA DQEKAIVDEL
710 720 730
IAVQGSPADI GGYYQPDPVK AAAVMRPSKI FNEAIASLG
Length:739
Mass (Da):78,945
Last modified:March 7, 2006 - v1
Checksum:i3FB68196C50F95F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD11572.1.
RefSeqiYP_481301.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD11572; ABD11572; Francci3_2203.
KEGGifra:Francci3_2203.
PATRICi21927560. VBIFraSp10456_2393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD11572.1.
RefSeqiYP_481301.1. NC_007777.1.

3D structure databases

ProteinModelPortaliQ2JAX0.
SMRiQ2JAX0. Positions 4-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi106370.Francci3_2203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD11572; ABD11572; Francci3_2203.
KEGGifra:Francci3_2203.
PATRICi21927560. VBIFraSp10456_2393.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciFSP106370:GI1F-2236-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3Imported.

Entry informationi

Entry nameiQ2JAX0_FRASC
AccessioniPrimary (citable) accession number: Q2JAX0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: April 1, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.