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Q2JAX0

- Q2JAX0_FRASC

UniProt

Q2JAX0 - Q2JAX0_FRASC

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Protein
Submitted name: Isocitrate dehydrogenase, NADP-dependent
Gene
Francci3_2203
Organism
Frankia sp. (strain CcI3)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451Substrate By similarityUniRule annotation
Sitei255 – 2551Critical for catalysis By similarityUniRule annotation
Metal bindingi348 – 3481Magnesium or manganese By similarityUniRule annotation
Sitei418 – 4181Critical for catalysis By similarityUniRule annotation
Binding sitei545 – 5451Substrate By similarityUniRule annotation
Metal bindingi546 – 5461Magnesium or manganese By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciFSP106370:GI1F-2236-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Francci3_2203Imported
OrganismiFrankia sp. (strain CcI3)Imported
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi106370.Francci3_2203.

Structurei

3D structure databases

ProteinModelPortaliQ2JAX0.
SMRiQ2JAX0. Positions 4-738.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1398Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiSIVKLMQ.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2JAX0-1 [UniParc]FASTAAdd to Basket

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MTDSTIIYTH TDEAPALATY SFLPVVQAYA ATAGVSVDSR DISLAGRIIA    50
SFPEDLEEAQ RIEDALAELG ELARTPEANI IKLPNISASI PQLKAAIVEL 100
QKRGYALPDY PDDPKTDEER EIRARYDKVK GSAVNPVLRE GNSDRRAPAS 150
VKNYARTHPH RMGAWTPDSK TNVATMGAGD FRSTEKSTII AAAGTLRIEL 200
AGDDGSTTVL LPSLPVLAGE VVDAAVLRVA ALREFLTAQI ARAKAEGVLF 250
SVHLKATMMK VSDPIIFGHV VRAFFPKTFA THGATLAAAG LSPNDGLGGI 300
LKGLESLPEG AQIKASFAAE LAEGPALAMV DSDRGITNLH VPSDVIVDAS 350
MPAMIRTSGH MWGPDGREAD TLAVLPDSSY AGIYQVAIDD CRAHGAYDPA 400
TMGSVANVGL MAQKAEEYGS HDKTFEIPTT GTVRIVDQAG TVVLEQAVAA 450
GDIFRACQTK DAPIRDWVKL AVARARATGD PAVFWLDENR AHDARLIEKV 500
RAYLPGHDTS GLRIEIKAPV DAIAFSLERI RRGENTISVT GNVLRDYLTD 550
LFPILELGTS AKMLSIVPLM NGGGLFETGA GGSAPKHVQQ LLRENYLRWD 600
SLGEFLALAA SFEQFARTTG NARAQVLADT LDRATATFLN EDKSPSRRLG 650
GLDNRGSHFY LALYWAQELA AQIGDPRLAE AFAGLAKTLA DQEKAIVDEL 700
IAVQGSPADI GGYYQPDPVK AAAVMRPSKI FNEAIASLG 739
Length:739
Mass (Da):78,945
Last modified:March 7, 2006 - v1
Checksum:i3FB68196C50F95F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD11572.1.
RefSeqiWP_011436619.1. NC_007777.1.
YP_481301.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD11572; ABD11572; Francci3_2203.
GeneIDi3906342.
KEGGifra:Francci3_2203.
PATRICi21927560. VBIFraSp10456_2393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD11572.1 .
RefSeqi WP_011436619.1. NC_007777.1.
YP_481301.1. NC_007777.1.

3D structure databases

ProteinModelPortali Q2JAX0.
SMRi Q2JAX0. Positions 4-738.
ModBasei Search...

Protein-protein interaction databases

STRINGi 106370.Francci3_2203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD11572 ; ABD11572 ; Francci3_2203 .
GeneIDi 3906342.
KEGGi fra:Francci3_2203.
PATRICi 21927560. VBIFraSp10456_2393.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi SIVKLMQ.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci FSP106370:GI1F-2236-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3Imported.

Entry informationi

Entry nameiQ2JAX0_FRASC
AccessioniPrimary (citable) accession number: Q2JAX0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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