ID   UPPP1_FRASC             Reviewed;         371 AA.
AC   Q2JAC3;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Undecaprenyl-diphosphatase 1;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase 1;
DE   AltName: Full=Bacitracin resistance protein 1;
GN   Name=uppP1; OrderedLocusNames=Francci3_2402;
OS   Frankia sp. (strain CcI3).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=106370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl
CC       diphosphate (UPP). Confers resistance to bacitracin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O =
CC       undecaprenyl phosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- MISCELLANEOUS: Bacitracin is thought to be involved in the
CC       inhibition of peptidoglycan synthesis by sequestering undecaprenyl
CC       diphosphate, thereby reducing the pool of lipid carrier available.
CC   -!- SIMILARITY: Belongs to the uppP family.
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DR   EMBL; CP000249; ABD11769.1; -; Genomic_DNA.
DR   RefSeq; YP_481498.1; -.
DR   GeneID; 3906385; -.
DR   GenomeReviews; CP000249_GR; Francci3_2402.
DR   KEGG; fra:Francci3_2402; -.
DR   HOGENOM; Q2JAC3; -.
DR   OMA; Q2JAC3; ANGMILL.
DR   BioCyc; FSP106370:FRANCCI3_2402-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01006; atypical; 1.
DR   InterPro; IPR003824; Bacitracin-R_BacA.
DR   Pfam; PF02673; BacA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Hydrolase;
KW   Membrane; Peptidoglycan synthesis; Transmembrane.
FT   CHAIN         1    371       Undecaprenyl-diphosphatase 1.
FT                                /FTId=PRO_0000250235.
FT   TRANSMEM     53     73       Potential.
FT   TRANSMEM    100    120       Potential.
FT   TRANSMEM    126    146       Potential.
FT   TRANSMEM    291    311       Potential.
FT   TRANSMEM    322    342       Potential.
FT   TRANSMEM    351    371       Potential.
SQ   SEQUENCE   371 AA;  38699 MW;  D1ABE74AF6AF4A84 CRC64;
     MSSFSYAEAG VIGALQGATE LFPVSSLGHS VLVPALIGGR WAADLDVSAP ESPYLAFIVA
     VHVATAAALI VAFRDDWRRI ITGLAVSVRD RRVTTADGRL AWLIILGTVP VGIVGLLLEH
     PLRTHLGRPL PAAVFLTVNG MIMLLGERLR RRSTTRGAPG PAGYRDEHTM PIPRSAPVTG
     RRVGTRPASG PLVAHGSAPG SGPGNHSKAV TTETALPEAE DVTLPEAETA LPEAETAARH
     ADRRLAALPR LDALLVGVAQ TAALAPGISR SGVTMIAGLS RGLSHLDAAR FAFLLATPVI
     LAAGLLKLPD LLGPLGDGVR GQTLFGAIVA GVVAYVSIRF LARWFETRTA TPFAVYCLVA
     GALCVVRFGI F
//