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Q2JAC3 (UPPP1_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 1

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene names
Name:uppP1
Ordered Locus Names:Francci3_2402
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006
PRO_0000250235

Regions

Transmembrane53 – 7321Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane291 – 31121Helical; Potential
Transmembrane322 – 34221Helical; Potential
Transmembrane351 – 37121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2JAC3 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: D1ABE74AF6AF4A84

FASTA37138,699
        10         20         30         40         50         60 
MSSFSYAEAG VIGALQGATE LFPVSSLGHS VLVPALIGGR WAADLDVSAP ESPYLAFIVA 

        70         80         90        100        110        120 
VHVATAAALI VAFRDDWRRI ITGLAVSVRD RRVTTADGRL AWLIILGTVP VGIVGLLLEH 

       130        140        150        160        170        180 
PLRTHLGRPL PAAVFLTVNG MIMLLGERLR RRSTTRGAPG PAGYRDEHTM PIPRSAPVTG 

       190        200        210        220        230        240 
RRVGTRPASG PLVAHGSAPG SGPGNHSKAV TTETALPEAE DVTLPEAETA LPEAETAARH 

       250        260        270        280        290        300 
ADRRLAALPR LDALLVGVAQ TAALAPGISR SGVTMIAGLS RGLSHLDAAR FAFLLATPVI 

       310        320        330        340        350        360 
LAAGLLKLPD LLGPLGDGVR GQTLFGAIVA GVVAYVSIRF LARWFETRTA TPFAVYCLVA 

       370 
GALCVVRFGI F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD11769.1.
RefSeqYP_481498.1. NC_007777.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_2402.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD11769; ABD11769; Francci3_2402.
GeneID3906385.
KEGGfra:Francci3_2402.
PATRIC21927976. VBIFraSp10456_2602.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAHEESARF.
OrthoDBEOG6S52GD.

Enzyme and pathway databases

BioCycFSP106370:GI1F-2435-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP1_FRASC
AccessionPrimary (citable) accession number: Q2JAC3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families