Reviewed, UniProtKB/Swiss-Prot Q2JAC3 (UPPP1_FRASC)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Ordered Locus Names:	Francci3_2402

Organism

Frankia sp. (strain CcI3) [Complete proteome] [HAMAP]

Taxonomic identifier

106370 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000250235
Regions
	Transmembrane	53 – 73	21	Potential
	Transmembrane	100 – 120	21	Potential
	Transmembrane	126 – 146	21	Potential
	Transmembrane	291 – 311	21	Potential
	Transmembrane	322 – 342	21	Potential
	Transmembrane	351 – 371	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2JAC3-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: D1ABE74AF6AF4A84	FASTA	371	38,699
	10 20 30 40 50 60 MSSFSYAEAG VIGALQGATE LFPVSSLGHS VLVPALIGGR WAADLDVSAP ESPYLAFIVA 70 80 90 100 110 120 VHVATAAALI VAFRDDWRRI ITGLAVSVRD RRVTTADGRL AWLIILGTVP VGIVGLLLEH 130 140 150 160 170 180 PLRTHLGRPL PAAVFLTVNG MIMLLGERLR RRSTTRGAPG PAGYRDEHTM PIPRSAPVTG 190 200 210 220 230 240 RRVGTRPASG PLVAHGSAPG SGPGNHSKAV TTETALPEAE DVTLPEAETA LPEAETAARH 250 260 270 280 290 300 ADRRLAALPR LDALLVGVAQ TAALAPGISR SGVTMIAGLS RGLSHLDAAR FAFLLATPVI 310 320 330 340 350 360 LAAGLLKLPD LLGPLGDGVR GQTLFGAIVA GVVAYVSIRF LARWFETRTA TPFAVYCLVA 370 GALCVVRFGI F

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000249 Genomic DNA. Translation: ABD11769.1.
RefSeq	YP_481498.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2JAC3.
Genome annotation databases
GeneID	3906385.
GenomeReviews	Gene locus Francci3_2402 in contig CP000249_GR.
KEGG	fra:Francci3_2402.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	GTHEARM.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. Divergent sequence. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_FRASC

Accession

Primary (citable) accession number: Q2JAC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	March 7, 2006
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)