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Q2JAC3

- UPPP1_FRASC

UniProt

Q2JAC3 - UPPP1_FRASC

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Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciFSP106370:GI1F-2435-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 1UniRule annotation
Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
Gene namesi
Name:uppP1UniRule annotation
Ordered Locus Names:Francci3_2402
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321HelicalUniRule annotationAdd
BLAST
Transmembranei100 – 12021HelicalUniRule annotationAdd
BLAST
Transmembranei126 – 14621HelicalUniRule annotationAdd
BLAST
Transmembranei291 – 31121HelicalUniRule annotationAdd
BLAST
Transmembranei322 – 34221HelicalUniRule annotationAdd
BLAST
Transmembranei351 – 37121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Undecaprenyl-diphosphatase 1PRO_0000250235Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi106370.Francci3_2402.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiHEESARF.
OrthoDBiEOG6S52GD.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2JAC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSFSYAEAG VIGALQGATE LFPVSSLGHS VLVPALIGGR WAADLDVSAP
60 70 80 90 100
ESPYLAFIVA VHVATAAALI VAFRDDWRRI ITGLAVSVRD RRVTTADGRL
110 120 130 140 150
AWLIILGTVP VGIVGLLLEH PLRTHLGRPL PAAVFLTVNG MIMLLGERLR
160 170 180 190 200
RRSTTRGAPG PAGYRDEHTM PIPRSAPVTG RRVGTRPASG PLVAHGSAPG
210 220 230 240 250
SGPGNHSKAV TTETALPEAE DVTLPEAETA LPEAETAARH ADRRLAALPR
260 270 280 290 300
LDALLVGVAQ TAALAPGISR SGVTMIAGLS RGLSHLDAAR FAFLLATPVI
310 320 330 340 350
LAAGLLKLPD LLGPLGDGVR GQTLFGAIVA GVVAYVSIRF LARWFETRTA
360 370
TPFAVYCLVA GALCVVRFGI F
Length:371
Mass (Da):38,699
Last modified:March 7, 2006 - v1
Checksum:iD1ABE74AF6AF4A84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD11769.1.
RefSeqiWP_011436814.1. NC_007777.1.
YP_481498.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD11769; ABD11769; Francci3_2402.
GeneIDi3906385.
KEGGifra:Francci3_2402.
PATRICi21927976. VBIFraSp10456_2602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD11769.1 .
RefSeqi WP_011436814.1. NC_007777.1.
YP_481498.1. NC_007777.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 106370.Francci3_2402.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD11769 ; ABD11769 ; Francci3_2402 .
GeneIDi 3906385.
KEGGi fra:Francci3_2402.
PATRICi 21927976. VBIFraSp10456_2602.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi HEESARF.
OrthoDBi EOG6S52GD.

Enzyme and pathway databases

BioCyci FSP106370:GI1F-2435-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3.

Entry informationi

Entry nameiUPPP1_FRASC
AccessioniPrimary (citable) accession number: Q2JAC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3