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Q2J9H6 (SYR_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Francci3_2705
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence ABD12066.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242024

Regions

Motif129 – 13911"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q2J9H6 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: 49513BC8DA1695C8

FASTA58863,622
        10         20         30         40         50         60 
MTAQTVRSLI NQVEIAVSAA IDRVLPEAAG ADPVVRPSEH ADFQSNAALA LAKRARTKPA 

        70         80         90        100        110        120 
DLATAVADAL RADGSTAVAD VTVSGPGFLN LALADATVWT QVAARLADPR LGIDLPEQSR 

       130        140        150        160        170        180 
RTVIDYSGPN IAKEMHVGHL RTTIIGDALA RVLGFLGAEV IRQNHLGDWG TQFGMLIQYL 

       190        200        210        220        230        240 
DEHPDATWHS DDLAPGTSTV SALDSLYRAA RKEFDADPGF ADRARARVVA LQAGDEDTVA 

       250        260        270        280        290        300 
RWREIVAESE VAFRQIYDRL GVLLEPSDSA GESFYNDRLL DIVDELTAAG IAQDSEGALV 

       310        320        330        340        350        360 
VLSQEVTGPD GDPATLMVRK TDGGYGYDTT DLATIRYRIR DLHADRLLYV VDARQALHFR 

       370        380        390        400        410        420 
LVFETARRAG WLTDAVDVAH VAFGTVLGPD GRPFKTRAGD TVKLMDLLDA ATGKARATVA 

       430        440        450        460        470        480 
EKDHALTDDD LDHIAEAAGI GAVKYADLST SRTKDYVFDV DRMVSFDGNT GVYLQYAHTR 

       490        500        510        520        530        540 
IQSILRKAGD MTATVDVALA LHPAERALAL QLDAFGGALT EVARLLEPHR LCNYLYELAR 

       550        560        570        580 
AFTDFYEACP VLQADPSTRA NRLALCHLTA RTLRQGLDLL GIAAPERM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD12066.1. Different initiation.
RefSeqYP_481795.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2J9H6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_2705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD12066; ABD12066; Francci3_2705.
GeneID3904695.
KEGGfra:Francci3_2705.
PATRIC21928654. VBIFraSp10456_2942.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
KOK01887.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycFSP106370:GI1F-2739-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_FRASC
AccessionPrimary (citable) accession number: Q2J9H6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 16, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries