ID   UPPP2_FRASC             Reviewed;         292 AA.
AC   Q2J987;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Undecaprenyl-diphosphatase 2;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase 2;
DE   AltName: Full=Bacitracin resistance protein 2;
GN   Name=uppP2; OrderedLocusNames=Francci3_2797;
OS   Frankia sp. (strain CcI3).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=106370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl
CC       diphosphate (UPP). Confers resistance to bacitracin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O =
CC       undecaprenyl phosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- MISCELLANEOUS: Bacitracin is thought to be involved in the
CC       inhibition of peptidoglycan synthesis by sequestering undecaprenyl
CC       diphosphate, thereby reducing the pool of lipid carrier available.
CC   -!- SIMILARITY: Belongs to the uppP family.
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DR   EMBL; CP000249; ABD12155.1; -; Genomic_DNA.
DR   RefSeq; YP_481884.1; -.
DR   GeneID; 3904943; -.
DR   GenomeReviews; CP000249_GR; Francci3_2797.
DR   KEGG; fra:Francci3_2797; -.
DR   HOGENOM; Q2J987; -.
DR   OMA; Q2J987; FGLLFKD.
DR   BioCyc; FSP106370:FRANCCI3_2797-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01006; -; 1.
DR   InterPro; IPR003824; Bacitracin-R_BacA.
DR   Pfam; PF02673; BacA; 1.
DR   TIGRFAMs; TIGR00753; undec_PP_bacA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Hydrolase;
KW   Membrane; Peptidoglycan synthesis; Transmembrane.
FT   CHAIN         1    292       Undecaprenyl-diphosphatase 2.
FT                                /FTId=PRO_0000250236.
FT   TRANSMEM     89    109       Potential.
FT   TRANSMEM    118    138       Potential.
FT   TRANSMEM    203    223       Potential.
FT   TRANSMEM    232    252       Potential.
FT   TRANSMEM    263    283       Potential.
SQ   SEQUENCE   292 AA;  31013 MW;  ECD5A9E64ED79D4B CRC64;
     MNFFEGTVLG LVQGLTEFLP VSSSAHLRIA AALAGWEDPG AAFTAVTQIG TETAVLIYFR
     RDIARIVAAW ARSLTRREMR KDPDARTGWL VILGTLPIGL LGVTLQDAIE GPFRDLRLIA
     TTLIVLGLIL GGADWYASKG RPQGRHSPLR PRKVLEDLSV RDGLLYGLAQ SAALIPGVSR
     SGATISGGLL LGYTREAAAR YSFLLAMPAV LASGVFELRS IGGKDADVAW GPTILATFVA
     FVTGYAAIAW FLRYISTRSF APFVLYRVGL GLLLFSLLVG GALSPDAGAP PG
//