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Q2J987 (UPPP2_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Ordered Locus Names:Francci3_2797
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000250236

Regions

Transmembrane89 – 10921Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane263 – 28321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2J987 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: ECD5A9E64ED79D4B

FASTA29231,013
        10         20         30         40         50         60 
MNFFEGTVLG LVQGLTEFLP VSSSAHLRIA AALAGWEDPG AAFTAVTQIG TETAVLIYFR 

        70         80         90        100        110        120 
RDIARIVAAW ARSLTRREMR KDPDARTGWL VILGTLPIGL LGVTLQDAIE GPFRDLRLIA 

       130        140        150        160        170        180 
TTLIVLGLIL GGADWYASKG RPQGRHSPLR PRKVLEDLSV RDGLLYGLAQ SAALIPGVSR 

       190        200        210        220        230        240 
SGATISGGLL LGYTREAAAR YSFLLAMPAV LASGVFELRS IGGKDADVAW GPTILATFVA 

       250        260        270        280        290 
FVTGYAAIAW FLRYISTRSF APFVLYRVGL GLLLFSLLVG GALSPDAGAP PG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD12155.1.
RefSeqYP_481884.1. NC_007777.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_2797.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD12155; ABD12155; Francci3_2797.
GeneID3904943.
KEGGfra:Francci3_2797.
PATRIC21928846. VBIFraSp10456_3038.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMASKTQIMF.
OrthoDBEOG6QP13M.
ProtClustDBPRK12554.

Enzyme and pathway databases

BioCycFSP106370:GI1F-2831-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP2_FRASC
AccessionPrimary (citable) accession number: Q2J987
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families