Reviewed, UniProtKB/Swiss-Prot Q2J987 (UPPP2_FRASC)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Ordered Locus Names:	Francci3_2797

Organism

Frankia sp. (strain CcI3) [Complete proteome] [HAMAP]

Taxonomic identifier

106370 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000250236
Regions
	Transmembrane	89 – 109	21	Potential
	Transmembrane	118 – 138	21	Potential
	Transmembrane	203 – 223	21	Potential
	Transmembrane	232 – 252	21	Potential
	Transmembrane	263 – 283	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2J987-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: ECD5A9E64ED79D4B	FASTA	292	31,013
	10 20 30 40 50 60 MNFFEGTVLG LVQGLTEFLP VSSSAHLRIA AALAGWEDPG AAFTAVTQIG TETAVLIYFR 70 80 90 100 110 120 RDIARIVAAW ARSLTRREMR KDPDARTGWL VILGTLPIGL LGVTLQDAIE GPFRDLRLIA 130 140 150 160 170 180 TTLIVLGLIL GGADWYASKG RPQGRHSPLR PRKVLEDLSV RDGLLYGLAQ SAALIPGVSR 190 200 210 220 230 240 SGATISGGLL LGYTREAAAR YSFLLAMPAV LASGVFELRS IGGKDADVAW GPTILATFVA 250 260 270 280 290 FVTGYAAIAW FLRYISTRSF APFVLYRVGL GLLLFSLLVG GALSPDAGAP PG

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000249 Genomic DNA. Translation: ABD12155.1.
RefSeq	YP_481884.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3904943.
GenomeReviews	Gene locus Francci3_2797 in contig CP000249_GR.
KEGG	fra:Francci3_2797.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2J987.
OMA	Q2J987. FGLLFKD.
Enzyme and pathway databases
BioCyc	FSP106370:FRANCCI3_2797-MON.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_FRASC

Accession

Primary (citable) accession number: Q2J987

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)