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Q2J8L2 (HIS4_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

EC=5.3.1.16
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene names
Name:hisA
Ordered Locus Names:Francci3_3023
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01014.

Sequence similarities

Belongs to the HisA/HisF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2522521-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014
PRO_0000290476

Sites

Active site101Proton acceptor By similarity
Active site1291Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2J8L2 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: B9106F8B83250B3E

FASTA25225,897
        10         20         30         40         50         60 
MTLTLLPAVD VADGRAVRLV QGEAGSETSY GDPREAALTW QRDGAEWIHL VDLDAAFGRG 

        70         80         90        100        110        120 
SNRELIAEVV RAVDVAVELS GGIRDDASLD AALATGAARV NIGTAALEDP DWVRRAIDRV 

       130        140        150        160        170        180 
GDRIAVGLDV RGTTLSARGW TRDGGELFDV LARLDADGCA RYVVTDVRRD GTLTGPNVEL 

       190        200        210        220        230        240 
LRSVTAATSR PVVASGGVAT LDDLTAIAVV PGVEGAIIGK ALYAGAFTLP EALAVAGNIG 

       250 
NIGNGCAGAV GR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD12380.1.
RefSeqYP_482109.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2J8L2.
SMRQ2J8L2. Positions 3-233.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_3023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD12380; ABD12380; Francci3_3023.
GeneID3904376.
KEGGfra:Francci3_3023.
PATRIC21929334. VBIFraSp10456_3283.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0106.
HOGENOMHOG000224614.
KOK01814.
K01817.
OMATNIDSEG.
OrthoDBEOG6H1Q3W.

Enzyme and pathway databases

BioCycFSP106370:GI1F-3058-MONOMER.
UniPathwayUPA00031; UER00009.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01014. HisA.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR010188. HisA_TrpF.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01919. hisA-trpF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS4_FRASC
AccessionPrimary (citable) accession number: Q2J8L2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways