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Q2J8L2

- HIS4_FRASC

UniProt

Q2J8L2 - HIS4_FRASC

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101Proton acceptorUniRule annotation
    Active sitei129 – 1291Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
    2. phosphoribosylanthranilate isomerase activity Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP
    2. tryptophan biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciFSP106370:GI1F-3058-MONOMER.
    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
    Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
    Gene namesi
    Name:hisAUniRule annotation
    Ordered Locus Names:Francci3_3023
    OrganismiFrankia sp. (strain CcI3)
    Taxonomic identifieri106370 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
    ProteomesiUP000001937: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2522521-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000290476Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi106370.Francci3_3023.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2J8L2.
    SMRiQ2J8L2. Positions 3-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    K01817.
    OMAiTNIDSEG.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR010188. HisA_TrpF.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01919. hisA-trpF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2J8L2-1 [UniParc]FASTAAdd to Basket

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    MTLTLLPAVD VADGRAVRLV QGEAGSETSY GDPREAALTW QRDGAEWIHL    50
    VDLDAAFGRG SNRELIAEVV RAVDVAVELS GGIRDDASLD AALATGAARV 100
    NIGTAALEDP DWVRRAIDRV GDRIAVGLDV RGTTLSARGW TRDGGELFDV 150
    LARLDADGCA RYVVTDVRRD GTLTGPNVEL LRSVTAATSR PVVASGGVAT 200
    LDDLTAIAVV PGVEGAIIGK ALYAGAFTLP EALAVAGNIG NIGNGCAGAV 250
    GR 252
    Length:252
    Mass (Da):25,897
    Last modified:March 7, 2006 - v1
    Checksum:iB9106F8B83250B3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD12380.1.
    RefSeqiWP_011437408.1. NC_007777.1.
    YP_482109.1. NC_007777.1.

    Genome annotation databases

    EnsemblBacteriaiABD12380; ABD12380; Francci3_3023.
    GeneIDi3904376.
    KEGGifra:Francci3_3023.
    PATRICi21929334. VBIFraSp10456_3283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD12380.1 .
    RefSeqi WP_011437408.1. NC_007777.1.
    YP_482109.1. NC_007777.1.

    3D structure databases

    ProteinModelPortali Q2J8L2.
    SMRi Q2J8L2. Positions 3-233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 106370.Francci3_3023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD12380 ; ABD12380 ; Francci3_3023 .
    GeneIDi 3904376.
    KEGGi fra:Francci3_3023.
    PATRICi 21929334. VBIFraSp10456_3283.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    K01817.
    OMAi TNIDSEG.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    BioCyci FSP106370:GI1F-3058-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR010188. HisA_TrpF.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01919. hisA-trpF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CcI3.

    Entry informationi

    Entry nameiHIS4_FRASC
    AccessioniPrimary (citable) accession number: Q2J8L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3