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Q2J8H8 (Q2J8H8_FRASC) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Ordered Locus Names:Francci3_3057
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP] EMBL ABD12414.1
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length945 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
Q2J8H8 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 7AC5B6E4F990A75E

FASTA945103,944
        10         20         30         40         50         60 
MAQDTPRKFS VITDGLPSQL PDIDPSETSE WLESLDAVIE ESGRGRARFL MLKLLERARE 

        70         80         90        100        110        120 
KAVGVPGLTS TDYINTISPE REPWFPGNEH IERRIRAYIR WNAAIMVSRA NRPAFNVGGH 

       130        140        150        160        170        180 
IATYASSASL YEVGFNHFFR GKDHLSSSPG SASGDQIFIQ GHASPGIYAR AFLEGRLTEK 

       190        200        210        220        230        240 
QLDAFRREGE SGGLSSYPHP RLMPDFWEFP TVSMGLGPIG AIYQARFNRY LLNRQIKDTS 

       250        260        270        280        290        300 
GSRVWAFLGD GEMDEPESIG ALGVAAREEL DNLIFVVNCN LQRLDGPVRG NGKIMQELES 

       310        320        330        340        350        360 
LFRGAGWNVI KVVWGRDWDP LLAKDTDGVL VNRMNTTPDG QFQTYSTSSG EYIREHFFGS 

       370        380        390        400        410        420 
DARLRRMVAD LSDDDLRKLS RGGHDYRKLY AAYKAATEHA GQPTVILAHT IKGWTLGKDF 

       430        440        450        460        470        480 
EARNATHQMK KLTKSELKEF RDRLYLEIPD SALSGDLPPY CHPGPDSEEI AYMRERRAAL 

       490        500        510        520        530        540 
GGSIPRRVVR AKPLPQPPAK IFDELRKGSG KQPVATTMAF VRLLKDLMKT KEMGARFVPV 

       550        560        570        580        590        600 
IPDEARTFGM DAMFPTAKIY SPHGQRYEAV DRELLLSYQE SETGQMLHEG ISEAGSMGSV 

       610        620        630        640        650        660 
IAAGTAYATH AQHMIPVYVF YSMFGFQRTG DQMWALGDQL GRGFLLGATA GRTTLNGEGL 

       670        680        690        700        710        720 
QHQDGHSLLL ASTNPACVAY DPAFAFELTH IVRDALDRMY GERDDNVFYY LTVYNEPVPQ 

       730        740        750        760        770        780 
PAEPAGLDPA QIISGMYRFR SAEDLAGGLP AAGAGVGSPP RAQLLASGTS IHWALAAQEI 

       790        800        810        820        830        840 
LAADFGVAAD LWSVTSWNEL RRDALDCDRA NLLNPEADDA VPYVTRALEG AAGPVVAVSD 

       850        860        870        880        890        900 
WMRAVPDQIS RWVPQPFTSL GTDGYGRSDT RAALRRHFKV DAESIVVATL EALVRAGEVK 

       910        920        930        940 
ATTVGDAIRR FGLRADKAGL DGPEAIVAGI RIVAGAEQDE RPISG

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000249 Genomic DNA. Translation: ABD12414.1.
RefSeqYP_482143.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2J8H8.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2J8H8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3904258.
GenomeReviewsGene locus Francci3_3057 in contig CP000249_GR.
KEGGfra:Francci3_3057.
PATRIC21929406. VBIFraSp10456_3318.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2609.
HOGENOMHBG289271.
OMAFRQEKSH.
PhylomeDBQ2J8H8.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2J8H8_FRASC
AccessionPrimary (citable) accession number: Q2J8H8
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info