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Q2J866 (ASSY_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:Francci3_3169
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000263927

Regions

Nucleotide binding8 – 169ATP By similarity

Sites

Binding site871Citrulline By similarity
Binding site921Citrulline By similarity
Binding site1171ATP; via amide nitrogen By similarity
Binding site1191Aspartate By similarity
Binding site1231Aspartate By similarity
Binding site1231Citrulline By similarity
Binding site1241Aspartate By similarity
Binding site1271Citrulline By similarity
Binding site1751Citrulline By similarity
Binding site2591Citrulline By similarity
Binding site2711Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2J866 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: B6BE674003171089

FASTA40043,040
        10         20         30         40         50         60 
MTERVVLAYS GGLDTSVAIG WIGAETGADV VALAVDVGQG GEDLEAIRQR ALTCGAVESI 

        70         80         90        100        110        120 
VVDAREEFAE SFVAPAIKSN ALYMDRYPLI SSLSRPVIVR HLVAAAREHG ADAIAHGCTG 

       130        140        150        160        170        180 
KGNDQVRFEV GVAALAPGLS VLAPVRDSGM TRDKAIAFAE ERGLPIDVSK KSPYSIDQNL 

       190        200        210        220        230        240 
WGRTAECGVL EDPWAQPPED VFVYSADPTV ARIPDEVTIS FIDGVPVGLD GRSLPLADLV 

       250        260        270        280        290        300 
AELNVRAGAH GVGRIDLIED RLVGIKSREI YECPAAITLL TAHRDLEDLT LERDVARFKR 

       310        320        330        340        350        360 
GIDQRWGEIV YDGLWYSPLK SALDAFVDSA SAGVSGEVRI RLVGGVAQVV GRRSPASLYD 

       370        380        390        400 
HALATYDAGD QFDQRDARGF IELWGLPTKV WAAREQRLNP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD12526.1.
RefSeqYP_482255.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2J866.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_3169.

Proteomic databases

PRIDEQ2J866.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD12526; ABD12526; Francci3_3169.
GeneID3903894.
KEGGfra:Francci3_3169.
PATRIC21929658. VBIFraSp10456_3441.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMAPWNEPTK.
OrthoDBEOG6K9QCV.

Enzyme and pathway databases

BioCycFSP106370:GI1F-3209-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_FRASC
AccessionPrimary (citable) accession number: Q2J866
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways