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Q2J838

- PYRF_FRASC

UniProt

Q2J838 - PYRF_FRASC

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321SubstrateUniRule annotation
Binding sitei54 – 541SubstrateUniRule annotation
Active sitei101 – 1011Proton donorUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Binding sitei215 – 2151SubstrateUniRule annotation
Binding sitei224 – 2241SubstrateUniRule annotation
Binding sitei244 – 2441Substrate; via amide nitrogenUniRule annotation
Binding sitei245 – 2451SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciFSP106370:GI1F-3238-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Francci3_3197
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_0000241859Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi106370.Francci3_3197.

Structurei

3D structure databases

ProteinModelPortaliQ2J838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 10810Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OMAiDIPNTMR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2J838-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAGRRSSGG RSAAAPRFTP PRGRAPLAVA LDAPDAATAL RWAAAVAPTV
60 70 80 90 100
AVLKIGLELF YREGPAIVTA LRAAGVLAGA GGAAVAAGGT GSAPELFLDL
110 120 130 140 150
KLHDIPATVA GGMRSITPLG PRFVTVHAAG GAAMIRAAIE AAPDVEVAVV
160 170 180 190 200
TVLTSLDVAA LSAIGLAGPP SDAVRRLAVL AVEAGARTLV CSPREVRMVR
210 220 230 240 250
MELGSNVTLI TPGVRPAGSE TGDQARTATP EAALVGGSDL VVVGRPITGA
260 270
PDPGVAARAI AAGLSAAGRA ADLL
Length:274
Mass (Da):26,909
Last modified:March 7, 2006 - v1
Checksum:iDB9EEB7F4076B416
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD12554.1.
RefSeqiYP_482283.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD12554; ABD12554; Francci3_3197.
GeneIDi3906163.
KEGGifra:Francci3_3197.
PATRICi21929716. VBIFraSp10456_3470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD12554.1 .
RefSeqi YP_482283.1. NC_007777.1.

3D structure databases

ProteinModelPortali Q2J838.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 106370.Francci3_3197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD12554 ; ABD12554 ; Francci3_3197 .
GeneIDi 3906163.
KEGGi fra:Francci3_3197.
PATRICi 21929716. VBIFraSp10456_3470.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OMAi DIPNTMR.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci FSP106370:GI1F-3238-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3.

Entry informationi

Entry nameiPYRF_FRASC
AccessioniPrimary (citable) accession number: Q2J838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3