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Q2J838

- PYRF_FRASC

UniProt

Q2J838 - PYRF_FRASC

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, Francci3_3197
Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321Substrate By similarity
Binding sitei54 – 541Substrate By similarity
Active sitei101 – 1011Proton donor By similarity
Binding sitei154 – 1541Substrate By similarity
Binding sitei215 – 2151Substrate By similarity
Binding sitei224 – 2241Substrate By similarity
Binding sitei244 – 2441Substrate; via amide nitrogen By similarity
Binding sitei245 – 2451Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciFSP106370:GI1F-3238-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Francci3_3197
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000241859Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi106370.Francci3_3197.

Structurei

3D structure databases

ProteinModelPortaliQ2J838.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 10810Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OMAiDIPNTMR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2J838-1 [UniParc]FASTAAdd to Basket

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MSAGRRSSGG RSAAAPRFTP PRGRAPLAVA LDAPDAATAL RWAAAVAPTV    50
AVLKIGLELF YREGPAIVTA LRAAGVLAGA GGAAVAAGGT GSAPELFLDL 100
KLHDIPATVA GGMRSITPLG PRFVTVHAAG GAAMIRAAIE AAPDVEVAVV 150
TVLTSLDVAA LSAIGLAGPP SDAVRRLAVL AVEAGARTLV CSPREVRMVR 200
MELGSNVTLI TPGVRPAGSE TGDQARTATP EAALVGGSDL VVVGRPITGA 250
PDPGVAARAI AAGLSAAGRA ADLL 274
Length:274
Mass (Da):26,909
Last modified:March 7, 2006 - v1
Checksum:iDB9EEB7F4076B416
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD12554.1.
RefSeqiYP_482283.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD12554; ABD12554; Francci3_3197.
GeneIDi3906163.
KEGGifra:Francci3_3197.
PATRICi21929716. VBIFraSp10456_3470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD12554.1 .
RefSeqi YP_482283.1. NC_007777.1.

3D structure databases

ProteinModelPortali Q2J838.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 106370.Francci3_3197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD12554 ; ABD12554 ; Francci3_3197 .
GeneIDi 3906163.
KEGGi fra:Francci3_3197.
PATRICi 21929716. VBIFraSp10456_3470.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OMAi DIPNTMR.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci FSP106370:GI1F-3238-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3.

Entry informationi

Entry nameiPYRF_FRASC
AccessioniPrimary (citable) accession number: Q2J838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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