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Q2J838 (PYRF_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:Francci3_3197
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000241859

Regions

Region99 – 10810Substrate binding By similarity

Sites

Active site1011Proton donor By similarity
Binding site321Substrate By similarity
Binding site541Substrate By similarity
Binding site1541Substrate By similarity
Binding site2151Substrate By similarity
Binding site2241Substrate By similarity
Binding site2441Substrate; via amide nitrogen By similarity
Binding site2451Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2J838 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: DB9EEB7F4076B416

FASTA27426,909
        10         20         30         40         50         60 
MSAGRRSSGG RSAAAPRFTP PRGRAPLAVA LDAPDAATAL RWAAAVAPTV AVLKIGLELF 

        70         80         90        100        110        120 
YREGPAIVTA LRAAGVLAGA GGAAVAAGGT GSAPELFLDL KLHDIPATVA GGMRSITPLG 

       130        140        150        160        170        180 
PRFVTVHAAG GAAMIRAAIE AAPDVEVAVV TVLTSLDVAA LSAIGLAGPP SDAVRRLAVL 

       190        200        210        220        230        240 
AVEAGARTLV CSPREVRMVR MELGSNVTLI TPGVRPAGSE TGDQARTATP EAALVGGSDL 

       250        260        270 
VVVGRPITGA PDPGVAARAI AAGLSAAGRA ADLL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD12554.1.
RefSeqYP_482283.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2J838.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_3197.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD12554; ABD12554; Francci3_3197.
GeneID3906163.
KEGGfra:Francci3_3197.
PATRIC21929716. VBIFraSp10456_3470.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226070.
KOK01591.
OMADIPNTMR.

Enzyme and pathway databases

BioCycFSP106370:GI1F-3238-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_FRASC
AccessionPrimary (citable) accession number: Q2J838
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways