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Q2J7E7 (MDH_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase
EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:Francci3_3441
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517

Subunit structure

Homodimer By similarity. HAMAP MF_01517

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Malate dehydrogenase HAMAP MF_01517
PRO_0000294386

Regions

Nucleotide binding12 – 187NAD By similarity
Nucleotide binding130 – 1323NAD By similarity

Sites

Active site1881Proton acceptor By similarity
Binding site931Substrate By similarity
Binding site991Substrate By similarity
Binding site1061NAD By similarity
Binding site1131NAD By similarity
Binding site1321Substrate By similarity
Binding site1631Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2J7E7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: B3C3BF8B1C5EC8CA

FASTA32934,399
        10         20         30         40         50         60 
MSSTPVNVTV TGAAGQIGYA LLFRIASGQL LGADTPVKLR LLEIPQAVRA AEGTALELED 

        70         80         90        100        110        120 
SAFPLLAGVD VFDDAKRAFE GTNVALLVGA RPRTKGMERG DLLSANGGIF KPQGEAINSG 

       130        140        150        160        170        180 
AAEDIRVLVV GNPANTNALI AQTHAPDVPA ERFTAMTRLD HNRAIAQLAK KLGVPSAEIK 

       190        200        210        220        230        240 
KITIWGNHSA TQYPDIFHAE VGGRSGAEAV GDQAWIADEF IPRVAKRGAE IIEVRGASSA 

       250        260        270        280        290        300 
ASAASAAIDH IFTWVNGTPA GDWTSAAIPS DGSYGVPEGL ISSFPVTASG GRFEIVQGLE 

       310        320 
LDAFSREKID ASVRELAEER EAVRALGLI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000249 Genomic DNA. Translation: ABD12795.1.
RefSeqYP_482524.1. NC_007777.1.

3D structure databases

HSSPHSSP built from PDB template 1WZE based on UniProtKB P10584.
ProteinModelPortalQ2J7E7.
SMRQ2J7E7. Positions 5-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2J7E7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3905681.
GenomeReviewsGene locus Francci3_3441 in contig CP000249_GR.
KEGGfra:Francci3_3441.
PATRIC21930278. VBIFraSp10456_3749.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHBG289884.
OMADPNVAFK.
ProtClustDBPRK05442.

Enzyme and pathway databases

BioCycFSP106370:FRANCCI3_3441-MONOMER.

Family and domain databases

HAMAPMF_01517. Malate_dehydrog_2.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00024.
PANTHERPTHR23382. MDH_SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_FRASC
AccessionPrimary (citable) accession number: Q2J7E7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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