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Q2J7A7 (Q2J7A7_FRASC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabH2 HAMAP MF_01815
Ordered Locus Names:Francci3_3482
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP] EMBL ABD12835.1
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region242 – 2465ACP-binding By similarity HAMAP MF_01815

Sites

Active site1161 By similarity HAMAP MF_01815
Active site2411 By similarity HAMAP MF_01815
Active site2711 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q2J7A7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: BB4E485C830EB40A

FASTA31532,538
        10         20         30         40         50         60 
MTELTGARML GLGVYRPARV VTNDEIAQRV DTSDAWIQAR TGIASRRIAD DEETIVAMGA 

        70         80         90        100        110        120 
AAAEKALAAA GLTADSIDLV IGATCTSPSQ IPGAGPQIAH RIGAGRAGAF DINGACAGFS 

       130        140        150        160        170        180 
YAVSTAADMV RAGTLRNVLV VATERLSDYT DWDDRSTCIL LADGAGAAVI GPAETNEIGP 

       190        200        210        220        230        240 
AVWGHDGSRP ETIQVPGYGD NSFRMEGQAV FRWAISLVPV LRQICEQAGV APEDLAGIVP 

       250        260        270        280        290        300 
HQANLRIVEA LVTGIGATNA AVARDVVDAG NTSAASIPLG LSRLLESGEI RRGDPVLLFG 

       310 
FGAGLTYCGQ LVRCP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000249 Genomic DNA. Translation: ABD12835.1.
RefSeqYP_482564.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2J7A7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2J7A7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3905216.
GenomeReviewsGene locus Francci3_3482 in contig CP000249_GR.
KEGGfra:Francci3_3482.
PATRIC21930374. VBIFraSp10456_3797.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMASNCFIFA.
ProtClustDBPRK12879.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ2J7A7_FRASC
AccessionPrimary (citable) accession number: Q2J7A7
Entry history
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info