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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi509MagnesiumUniRule annotation1
Metal bindingi515MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Francci3_3555
OrganismiFrankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
Proteomesi
  • UP000001937 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296571 – 729Polyribonucleotide nucleotidyltransferaseAdd BLAST729

Interactioni

Protein-protein interaction databases

STRINGi106370.Francci3_3555.

Structurei

3D structure databases

ProteinModelPortaliQ2J735.
SMRiQ2J735.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini575 – 634KHUniRule annotationAdd BLAST60
Domaini646 – 718S1 motifUniRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR014069. GPSI/PNP.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2J735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSTHAAEA VIATPAGDRT VRFETGRLAK QAAGSAVAYL GDTMVLSATT
60 70 80 90 100
VSKQPKEQLD FFPLTVDVEE RMYAAGRIPG SFFRREGRPS EDAILTCRLI
110 120 130 140 150
DRPLRPSFAK GLRNEIQVVA TVLALDPDTL YDVVAINAAS ASTTLSGLPF
160 170 180 190 200
TGPIGATRVG FVDGEWIAFP THAELARATF DMVVAGRVIE DGSDVAIMMV
210 220 230 240 250
EAEATPGTVE LLAHGAPAPT EEVVAAGLEA AKPAIRELCR AQSELAALAA
260 270 280 290 300
KPAREFPVFI DYHDDVLDAL SAAIGDELSA ALRIPGKAER ENELDRVRQL
310 320 330 340 350
AAEKVASQFE GREKEIGAAY RALTKKLVRS RIVTESVRID GRSTTEIRAL
360 370 380 390 400
SAEVDYIPRV HGSALFERGE TQILGVTTLA MLRMEQTVDT LNPDRTKRYM
410 420 430 440 450
HNYNFPPYST GETGRVGSPK RREIGHGALA ERALLPVLPS REEFPYAIRQ
460 470 480 490 500
VSEALGSNGS TSMGSVCAST LSLLNAGVPL KAPVAGIAMG LIHADDSYVT
510 520 530 540 550
LTDILGAEDA YGDMDFKVAG TRDFVTALQL DTKLDGIPAS VLAAALQQAR
560 570 580 590 600
GARLAILDVM AEAIGSPDEM SAHAPRVISV KIPVDKIGEV IGPKGKMINQ
610 620 630 640 650
IQADSGAEIT VEDDGTIYIG AVDGPSAESA RSAINAIANP QMPEVGERYL
660 670 680 690 700
GTIVKITNFG AFVSLTPGRD GLLHVSKLKT LSGGKRVEKV EDVLTVGQKL
710 720
QVEITEIDSR GKISLSPSAE AADAAAAAS
Length:729
Mass (Da):77,332
Last modified:March 7, 2006 - v1
Checksum:iC86321ACC5937546
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD12907.1.
RefSeqiWP_011437931.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD12907; ABD12907; Francci3_3555.
GeneIDi32158403.
KEGGifra:Francci3_3555.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPNP_FRACC
AccessioniPrimary (citable) accession number: Q2J735
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 7, 2006
Last modified: July 5, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families