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Q2J6Y1 (DDL_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Francci3_3609
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341101

Regions

Domain169 – 373205ATP-grasp
Nucleotide binding196 – 25156ATP By similarity

Sites

Metal binding3271Magnesium or manganese 1 By similarity
Metal binding3401Magnesium or manganese 1 By similarity
Metal binding3401Magnesium or manganese 2 By similarity
Metal binding3421Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2J6Y1 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: CB9BF0B8882451AA

FASTA38339,975
        10         20         30         40         50         60 
MAGSRRRIRL ALLFGGRSTE HAISCISASG VLRALDRDVY DVVPVGIDTH GRWVVLPDDP 

        70         80         90        100        110        120 
TALAVTGDRL PAVVAAHGES VVLAADPTTP GLLPCRPRGG LDSVRNTLGS SDALGSSDIP 

       130        140        150        160        170        180 
GDIDVVFPLL HGPFGEDGTV QGLLEMAGLP YVGSGVFASA AAMDKQHMKA LLRAAGLPVG 

       190        200        210        220        230        240 
SYAVLRAGDT LTGADQERLG LPVFVKPARG GSSIGISRVE AWADLDTAIK AARASDPKVL 

       250        260        270        280        290        300 
VESAIVGREI ECGVLGILDG PGAEASVPAE ITVTSSAGFY DFEAKYMSDA THFDVPANLS 

       310        320        330        340        350        360 
HAVREEVRGA AIAAFEALDC AGLARVDMFV TADDHVIINE VNTMPGFTPT SMFPRMWEAS 

       370        380 
GVTYPQLVDR LVRLALRDGA GLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD12961.1.
RefSeqYP_482690.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2J6Y1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_3609.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD12961; ABD12961; Francci3_3609.
GeneID3904163.
KEGGfra:Francci3_3609.
PATRIC21930652. VBIFraSp10456_3936.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAIECGVLG.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycFSP106370:GI1F-3652-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 2 hits.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_FRASC
AccessionPrimary (citable) accession number: Q2J6Y1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways