ID   BIOD_FRASC              Reviewed;         238 AA.
AC   Q2J6H9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Dethiobiotin synthetase;
DE            EC=6.3.3.3;
DE   AltName: Full=Dethiobiotin synthase;
DE   AltName: Full=DTB synthetase;
DE            Short=DTBS;
GN   Name=bioD; OrderedLocusNames=Francci3_3762;
OS   Frankia sp. (strain CcI3).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=106370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + 7,8-diaminononanoate + CO(2) = ADP +
CC       phosphate + dethiobiotin.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis; biotin from
CC       6-carboxyhexanoyl-CoA: step 3/4.
CC   -!- SIMILARITY: Belongs to the dethiobiotin synthetase family.
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DR   EMBL; CP000249; ABD13113.1; -; Genomic_DNA.
DR   RefSeq; YP_482842.1; -.
DR   GeneID; 3906046; -.
DR   GenomeReviews; CP000249_GR; Francci3_3762.
DR   KEGG; fra:Francci3_3762; -.
DR   HOGENOM; Q2J6H9; -.
DR   OMA; Q2J6H9; PAGIVFV.
DR   BioCyc; FSP106370:FRANCCI3_3762-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004141; F:dethiobiotin synthase activity; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0009102; P:biotin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00336; -; 1.
DR   InterPro; IPR004472; BioD_synth.
DR   PIRSF; PIRSF006755; DTB_synth; 1.
DR   TIGRFAMs; TIGR00347; bioD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Biotin biosynthesis; Complete proteome; Ligase;
KW   Magnesium; Nucleotide-binding.
FT   CHAIN         1    238       Dethiobiotin synthetase.
FT                                /FTId=PRO_0000302511.
FT   NP_BIND       8     16       ATP (By similarity).
SQ   SEQUENCE   238 AA;  24273 MW;  E82AC3C553209B84 CRC64;
     MTALVVTGTG TGVGKTVVTA AIGALAHDRH HAVAVVKPAQ TGVGPGELGD VDLVRDLTGI
     TDVHELARYP DPLAPATAAR RSGHRAVDLD ELAARIGTLA DSRDLVLVEG AGGLLVRYDA
     GGATLADLAR VLRAPVLVVT AAGLGALNDT ALTLEALAHR GLDLAGVVVG SWPAEPDLAC
     RCNLIDLESL AARPLAGVLP AGAGLLARLE FLAVARASLQ PALGGTFRAQ EFRARYET
//