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Q2J645

- PCKG_FRASC

UniProt

Q2J645 - PCKG_FRASC

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei82 – 821SubstrateUniRule annotation
    Binding sitei223 – 2231Substrate; via amide nitrogenUniRule annotation
    Metal bindingi230 – 2301ManganeseUniRule annotation
    Binding sitei230 – 2301SubstrateUniRule annotation
    Metal bindingi250 – 2501Manganese; via tele nitrogenUniRule annotation
    Binding sitei272 – 2721SubstrateUniRule annotation
    Active sitei274 – 2741UniRule annotation
    Metal bindingi297 – 2971ManganeseUniRule annotation
    Binding sitei389 – 3891GTPUniRule annotation
    Binding sitei420 – 4201GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi273 – 2786GTPUniRule annotation
    Nucleotide bindingi515 – 5184GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFSP106370:GI1F-3948-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:Francci3_3897
    OrganismiFrankia sp. (strain CcI3)
    Taxonomic identifieri106370 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
    ProteomesiUP000001937: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 609609Phosphoenolpyruvate carboxykinase [GTP]PRO_1000060290Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi106370.Francci3_3897.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2J645.
    SMRiQ2J645. Positions 13-606.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni387 – 3893Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2J645-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTAAQVSGL DVAPTRHARL VAWVREIAEL TQPDRVEWCD GSEAEFDRLT    50
    SLLIEQGTLV RLNDEKRPNS FYAASDPGDV ARVEDRTYIC SEQAEDAGPT 100
    NNWLDPAEMR ATLRGLFAGC MRGRTMYVVP FCMGPLGSRI SALGVEITDS 150
    PYVVISMRTM TRMGTPALEQ LGTDGFFVPA VHSLGAPLEP GQADVPWPCN 200
    TTKYITHFPE TREIWSYGSG YGGNALLGKK CYALRIASVM ARDEGWLAEH 250
    MLILKLTSPA GKVHYIAAAF PSACGKTNLA MLIPTLPGWQ AETVGDDIAW 300
    MRFGEDGRLY AVNPEAGFFG VAPGTGEQTN PNAVRTLWGN AIYTNVARTD 350
    NGDVWWEGLT KQPPAHLIDW KGRDWTPESS EPAAHPNARF TVPAGQCPTI 400
    APEWEDPRGV PISAILFGGR RATAVPLVTE APDWRRGVFF GSIVASETTA 450
    AQAGAIGKLR RDPFAMLPFC GYNMADYFAH WLEVGQKADQ TKLPRVYYVN 500
    WFRKSPEGRF LWPGFGDNSR VLAWIVGRLE GTAAGVETPL GVLPTKDALP 550
    VDGIDIAEED LETLLTVDVE VWKQEAQLIP EHYQTFGERL PAALWTEHEA 600
    LVERLNSAD 609
    Length:609
    Mass (Da):66,912
    Last modified:March 7, 2006 - v1
    Checksum:i3790D69E45471916
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD13247.1.
    RefSeqiYP_482976.1. NC_007777.1.

    Genome annotation databases

    EnsemblBacteriaiABD13247; ABD13247; Francci3_3897.
    GeneIDi3906665.
    KEGGifra:Francci3_3897.
    PATRICi21931270. VBIFraSp10456_4238.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD13247.1 .
    RefSeqi YP_482976.1. NC_007777.1.

    3D structure databases

    ProteinModelPortali Q2J645.
    SMRi Q2J645. Positions 13-606.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 106370.Francci3_3897.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD13247 ; ABD13247 ; Francci3_3897 .
    GeneIDi 3906665.
    KEGGi fra:Francci3_3897.
    PATRICi 21931270. VBIFraSp10456_4238.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci FSP106370:GI1F-3948-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CcI3.

    Entry informationi

    Entry nameiPCKG_FRASC
    AccessioniPrimary (citable) accession number: Q2J645
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3