SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2J641

- SYL_FRASC

UniProt

Q2J641 - SYL_FRASC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Leucine--tRNA ligase
Gene
leuS, Francci3_3901
Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei834 – 8341ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFSP106370:GI1F-3952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Francci3_3901
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10641064Leucine--tRNA ligaseUniRule annotation
PRO_0000334759Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi106370.Francci3_3901.

Structurei

3D structure databases

ProteinModelPortaliQ2J641.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi106 – 11712"HIGH" regionUniRule annotation
Add
BLAST
Motifi831 – 8355"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 3 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 3 hits.

Sequencei

Sequence statusi: Complete.

Q2J641-1 [UniParc]FASTAAdd to Basket

« Hide

MARAMSETAE PGARTGAADT TVAPTGASGG IIPAAAGTAG GAPAGTGSVE     50
PSFRYDARLA ADIERRWQRR WADEGTFNSP NPVGPLSTGF EKVAGREPFY 100
IMDMFPYPSG SGLHVGHPLG YIGTDVFARY LRMSGRHVLH PFGYDSFGLP 150
AEQYAINTGQ HPRDTTNANI ANMRRQLSRL GLGHDTRREI ATTDVGYYRW 200
TQWIFQQIFN SWYDPQAGRA RPIAELIEEF AAGTRAPVAG PAGGNTAVSV 250
DAVRAANPAG LAWTELDEVS RRKVVNAHRL AYISEQLVNW CPGLGTVLAN 300
EEVTADGRSD IGNYPVFRRP LKQWILRITA YAERLISDLD LVDWPDSIKQ 350
MQRNWISPSE GASVEFTVVA PGEEAGASDP SGSSTARRIE VYTTRPDTLA 400
GATFLVLAPE HPLADALIAD TWPADTPVSW RFPAGRPGGG TEPADTAGPE 450
AGADPAWTPR AAVDAYREFA AHRSDRQRGE EVIDRTGVFT GSYVRNPVGG 500
GVIPVFLADY VLLGYGTGAI MAVPAHDSRD FSFARAFDLP IPAVLEPDAD 550
WYAAHGVVPA TPSAQWPEAF SGAGEYRPGP ASAPVLVGLS KSEAIKATVH 600
WLEEIGAGRS ARSYRLRDWL FSRQRYWGEP FPIVFDVDGL PHAVPDELLP 650
IELPEMTDFR PTAMAEDDAS DPVPPLARVA DWVTVTLDLG DGPKQYRRET 700
NTMPQWAGSC WYYLRYLDPT NTERFVDPTV ERYWMARPGA VPGDGGVDLY 750
VGGVEHAVLH LLYARFWHKV LYDLGHVSTK EPFKRLFNQG YIQADAFTDA 800
RGMYVPAAEV TATPDGRFLF QGAPVNRRSG KMGKSLKNSV SPDEMYDRFG 850
ADTLRVYEMA MGPLDADRPW HTDDIVGSHR FLQRLWRTVV DETTGAAAVV 900
DEPLDDEALR VLHRTILTVT AEYAGLRFNT AVARLIELTN FVSKSYGKSP 950
TPRALAEPLT LMAAPLAPHI AEELWSRLGH EESVSTVAFP IGDPALAAES 1000
VRTIPVQVNG KVRFTIEVPD GSAEQTVRDL LAAHPEFARQ TDGRTIKKII 1050
VVPGRIVNIA ISPA 1064
Length:1,064
Mass (Da):116,146
Last modified:March 7, 2006 - v1
Checksum:i8AB4FEFDF66F6DF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD13251.1.
RefSeqiWP_011438275.1. NC_007777.1.
YP_482980.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD13251; ABD13251; Francci3_3901.
GeneIDi3906669.
KEGGifra:Francci3_3901.
PATRICi21931278. VBIFraSp10456_4242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD13251.1 .
RefSeqi WP_011438275.1. NC_007777.1.
YP_482980.1. NC_007777.1.

3D structure databases

ProteinModelPortali Q2J641.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 106370.Francci3_3901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD13251 ; ABD13251 ; Francci3_3901 .
GeneIDi 3906669.
KEGGi fra:Francci3_3901.
PATRICi 21931278. VBIFraSp10456_4242.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci FSP106370:GI1F-3952-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 3 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 3 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3.

Entry informationi

Entry nameiSYL_FRASC
AccessioniPrimary (citable) accession number: Q2J641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi