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Q2J641

- SYL_FRASC

UniProt

Q2J641 - SYL_FRASC

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei834 – 8341ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFSP106370:GI1F-3952-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Francci3_3901
    OrganismiFrankia sp. (strain CcI3)
    Taxonomic identifieri106370 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
    ProteomesiUP000001937: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10641064Leucine--tRNA ligasePRO_0000334759Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi106370.Francci3_3901.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2J641.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi106 – 11712"HIGH" regionAdd
    BLAST
    Motifi831 – 8355"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiKGNPLES.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 3 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 2 hits.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q2J641-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARAMSETAE PGARTGAADT TVAPTGASGG IIPAAAGTAG GAPAGTGSVE     50
    PSFRYDARLA ADIERRWQRR WADEGTFNSP NPVGPLSTGF EKVAGREPFY 100
    IMDMFPYPSG SGLHVGHPLG YIGTDVFARY LRMSGRHVLH PFGYDSFGLP 150
    AEQYAINTGQ HPRDTTNANI ANMRRQLSRL GLGHDTRREI ATTDVGYYRW 200
    TQWIFQQIFN SWYDPQAGRA RPIAELIEEF AAGTRAPVAG PAGGNTAVSV 250
    DAVRAANPAG LAWTELDEVS RRKVVNAHRL AYISEQLVNW CPGLGTVLAN 300
    EEVTADGRSD IGNYPVFRRP LKQWILRITA YAERLISDLD LVDWPDSIKQ 350
    MQRNWISPSE GASVEFTVVA PGEEAGASDP SGSSTARRIE VYTTRPDTLA 400
    GATFLVLAPE HPLADALIAD TWPADTPVSW RFPAGRPGGG TEPADTAGPE 450
    AGADPAWTPR AAVDAYREFA AHRSDRQRGE EVIDRTGVFT GSYVRNPVGG 500
    GVIPVFLADY VLLGYGTGAI MAVPAHDSRD FSFARAFDLP IPAVLEPDAD 550
    WYAAHGVVPA TPSAQWPEAF SGAGEYRPGP ASAPVLVGLS KSEAIKATVH 600
    WLEEIGAGRS ARSYRLRDWL FSRQRYWGEP FPIVFDVDGL PHAVPDELLP 650
    IELPEMTDFR PTAMAEDDAS DPVPPLARVA DWVTVTLDLG DGPKQYRRET 700
    NTMPQWAGSC WYYLRYLDPT NTERFVDPTV ERYWMARPGA VPGDGGVDLY 750
    VGGVEHAVLH LLYARFWHKV LYDLGHVSTK EPFKRLFNQG YIQADAFTDA 800
    RGMYVPAAEV TATPDGRFLF QGAPVNRRSG KMGKSLKNSV SPDEMYDRFG 850
    ADTLRVYEMA MGPLDADRPW HTDDIVGSHR FLQRLWRTVV DETTGAAAVV 900
    DEPLDDEALR VLHRTILTVT AEYAGLRFNT AVARLIELTN FVSKSYGKSP 950
    TPRALAEPLT LMAAPLAPHI AEELWSRLGH EESVSTVAFP IGDPALAAES 1000
    VRTIPVQVNG KVRFTIEVPD GSAEQTVRDL LAAHPEFARQ TDGRTIKKII 1050
    VVPGRIVNIA ISPA 1064
    Length:1,064
    Mass (Da):116,146
    Last modified:March 7, 2006 - v1
    Checksum:i8AB4FEFDF66F6DF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD13251.1.
    RefSeqiWP_011438275.1. NC_007777.1.
    YP_482980.1. NC_007777.1.

    Genome annotation databases

    EnsemblBacteriaiABD13251; ABD13251; Francci3_3901.
    GeneIDi3906669.
    KEGGifra:Francci3_3901.
    PATRICi21931278. VBIFraSp10456_4242.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD13251.1 .
    RefSeqi WP_011438275.1. NC_007777.1.
    YP_482980.1. NC_007777.1.

    3D structure databases

    ProteinModelPortali Q2J641.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 106370.Francci3_3901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD13251 ; ABD13251 ; Francci3_3901 .
    GeneIDi 3906669.
    KEGGi fra:Francci3_3901.
    PATRICi 21931278. VBIFraSp10456_4242.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi KGNPLES.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci FSP106370:GI1F-3952-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 3 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 2 hits.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CcI3.

    Entry informationi

    Entry nameiSYL_FRASC
    AccessioniPrimary (citable) accession number: Q2J641
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3