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Q2J641

- SYL_FRASC

UniProt

Q2J641 - SYL_FRASC

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei834 – 8341ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFSP106370:GI1F-3952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Francci3_3901
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10641064Leucine--tRNA ligasePRO_0000334759Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi106370.Francci3_3901.

Structurei

3D structure databases

ProteinModelPortaliQ2J641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi106 – 11712"HIGH" regionAdd
BLAST
Motifi831 – 8355"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 3 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 3 hits.

Sequencei

Sequence statusi: Complete.

Q2J641-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARAMSETAE PGARTGAADT TVAPTGASGG IIPAAAGTAG GAPAGTGSVE
60 70 80 90 100
PSFRYDARLA ADIERRWQRR WADEGTFNSP NPVGPLSTGF EKVAGREPFY
110 120 130 140 150
IMDMFPYPSG SGLHVGHPLG YIGTDVFARY LRMSGRHVLH PFGYDSFGLP
160 170 180 190 200
AEQYAINTGQ HPRDTTNANI ANMRRQLSRL GLGHDTRREI ATTDVGYYRW
210 220 230 240 250
TQWIFQQIFN SWYDPQAGRA RPIAELIEEF AAGTRAPVAG PAGGNTAVSV
260 270 280 290 300
DAVRAANPAG LAWTELDEVS RRKVVNAHRL AYISEQLVNW CPGLGTVLAN
310 320 330 340 350
EEVTADGRSD IGNYPVFRRP LKQWILRITA YAERLISDLD LVDWPDSIKQ
360 370 380 390 400
MQRNWISPSE GASVEFTVVA PGEEAGASDP SGSSTARRIE VYTTRPDTLA
410 420 430 440 450
GATFLVLAPE HPLADALIAD TWPADTPVSW RFPAGRPGGG TEPADTAGPE
460 470 480 490 500
AGADPAWTPR AAVDAYREFA AHRSDRQRGE EVIDRTGVFT GSYVRNPVGG
510 520 530 540 550
GVIPVFLADY VLLGYGTGAI MAVPAHDSRD FSFARAFDLP IPAVLEPDAD
560 570 580 590 600
WYAAHGVVPA TPSAQWPEAF SGAGEYRPGP ASAPVLVGLS KSEAIKATVH
610 620 630 640 650
WLEEIGAGRS ARSYRLRDWL FSRQRYWGEP FPIVFDVDGL PHAVPDELLP
660 670 680 690 700
IELPEMTDFR PTAMAEDDAS DPVPPLARVA DWVTVTLDLG DGPKQYRRET
710 720 730 740 750
NTMPQWAGSC WYYLRYLDPT NTERFVDPTV ERYWMARPGA VPGDGGVDLY
760 770 780 790 800
VGGVEHAVLH LLYARFWHKV LYDLGHVSTK EPFKRLFNQG YIQADAFTDA
810 820 830 840 850
RGMYVPAAEV TATPDGRFLF QGAPVNRRSG KMGKSLKNSV SPDEMYDRFG
860 870 880 890 900
ADTLRVYEMA MGPLDADRPW HTDDIVGSHR FLQRLWRTVV DETTGAAAVV
910 920 930 940 950
DEPLDDEALR VLHRTILTVT AEYAGLRFNT AVARLIELTN FVSKSYGKSP
960 970 980 990 1000
TPRALAEPLT LMAAPLAPHI AEELWSRLGH EESVSTVAFP IGDPALAAES
1010 1020 1030 1040 1050
VRTIPVQVNG KVRFTIEVPD GSAEQTVRDL LAAHPEFARQ TDGRTIKKII
1060
VVPGRIVNIA ISPA
Length:1,064
Mass (Da):116,146
Last modified:March 7, 2006 - v1
Checksum:i8AB4FEFDF66F6DF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD13251.1.
RefSeqiWP_011438275.1. NC_007777.1.
YP_482980.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD13251; ABD13251; Francci3_3901.
GeneIDi3906669.
KEGGifra:Francci3_3901.
PATRICi21931278. VBIFraSp10456_4242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000249 Genomic DNA. Translation: ABD13251.1 .
RefSeqi WP_011438275.1. NC_007777.1.
YP_482980.1. NC_007777.1.

3D structure databases

ProteinModelPortali Q2J641.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 106370.Francci3_3901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD13251 ; ABD13251 ; Francci3_3901 .
GeneIDi 3906669.
KEGGi fra:Francci3_3901.
PATRICi 21931278. VBIFraSp10456_4242.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci FSP106370:GI1F-3952-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 3 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 3 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3.

Entry informationi

Entry nameiSYL_FRASC
AccessioniPrimary (citable) accession number: Q2J641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3