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Q2J641 (SYL_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Francci3_3901
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Protein attributes

Sequence length1064 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10641064Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334759

Regions

Motif106 – 11712"HIGH" region HAMAP-Rule MF_00049
Motif831 – 8355"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site8341ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2J641 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 8AB4FEFDF66F6DF6

FASTA1,064116,146
        10         20         30         40         50         60 
MARAMSETAE PGARTGAADT TVAPTGASGG IIPAAAGTAG GAPAGTGSVE PSFRYDARLA 

        70         80         90        100        110        120 
ADIERRWQRR WADEGTFNSP NPVGPLSTGF EKVAGREPFY IMDMFPYPSG SGLHVGHPLG 

       130        140        150        160        170        180 
YIGTDVFARY LRMSGRHVLH PFGYDSFGLP AEQYAINTGQ HPRDTTNANI ANMRRQLSRL 

       190        200        210        220        230        240 
GLGHDTRREI ATTDVGYYRW TQWIFQQIFN SWYDPQAGRA RPIAELIEEF AAGTRAPVAG 

       250        260        270        280        290        300 
PAGGNTAVSV DAVRAANPAG LAWTELDEVS RRKVVNAHRL AYISEQLVNW CPGLGTVLAN 

       310        320        330        340        350        360 
EEVTADGRSD IGNYPVFRRP LKQWILRITA YAERLISDLD LVDWPDSIKQ MQRNWISPSE 

       370        380        390        400        410        420 
GASVEFTVVA PGEEAGASDP SGSSTARRIE VYTTRPDTLA GATFLVLAPE HPLADALIAD 

       430        440        450        460        470        480 
TWPADTPVSW RFPAGRPGGG TEPADTAGPE AGADPAWTPR AAVDAYREFA AHRSDRQRGE 

       490        500        510        520        530        540 
EVIDRTGVFT GSYVRNPVGG GVIPVFLADY VLLGYGTGAI MAVPAHDSRD FSFARAFDLP 

       550        560        570        580        590        600 
IPAVLEPDAD WYAAHGVVPA TPSAQWPEAF SGAGEYRPGP ASAPVLVGLS KSEAIKATVH 

       610        620        630        640        650        660 
WLEEIGAGRS ARSYRLRDWL FSRQRYWGEP FPIVFDVDGL PHAVPDELLP IELPEMTDFR 

       670        680        690        700        710        720 
PTAMAEDDAS DPVPPLARVA DWVTVTLDLG DGPKQYRRET NTMPQWAGSC WYYLRYLDPT 

       730        740        750        760        770        780 
NTERFVDPTV ERYWMARPGA VPGDGGVDLY VGGVEHAVLH LLYARFWHKV LYDLGHVSTK 

       790        800        810        820        830        840 
EPFKRLFNQG YIQADAFTDA RGMYVPAAEV TATPDGRFLF QGAPVNRRSG KMGKSLKNSV 

       850        860        870        880        890        900 
SPDEMYDRFG ADTLRVYEMA MGPLDADRPW HTDDIVGSHR FLQRLWRTVV DETTGAAAVV 

       910        920        930        940        950        960 
DEPLDDEALR VLHRTILTVT AEYAGLRFNT AVARLIELTN FVSKSYGKSP TPRALAEPLT 

       970        980        990       1000       1010       1020 
LMAAPLAPHI AEELWSRLGH EESVSTVAFP IGDPALAAES VRTIPVQVNG KVRFTIEVPD 

      1030       1040       1050       1060 
GSAEQTVRDL LAAHPEFARQ TDGRTIKKII VVPGRIVNIA ISPA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000249 Genomic DNA. Translation: ABD13251.1.
RefSeqYP_482980.1. NC_007777.1.

3D structure databases

ProteinModelPortalQ2J641.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING106370.Francci3_3901.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD13251; ABD13251; Francci3_3901.
GeneID3906669.
KEGGfra:Francci3_3901.
PATRIC21931278. VBIFraSp10456_4242.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAKGNPLES.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycFSP106370:GI1F-3952-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 3 hits.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 2 hits.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 3 hits.
ProtoNetSearch...

Entry information

Entry nameSYL_FRASC
AccessionPrimary (citable) accession number: Q2J641
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries