ID   UPPP3_FRASC             Reviewed;         278 AA.
AC   Q2J4I7;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Undecaprenyl-diphosphatase 3;
DE            EC=3.6.1.27;
DE   AltName: Full=Undecaprenyl pyrophosphate phosphatase 3;
DE   AltName: Full=Bacitracin resistance protein 3;
GN   Name=uppP3; OrderedLocusNames=Francci3_4459;
OS   Frankia sp. (strain CcI3).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=106370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl
CC       diphosphate (UPP). Confers resistance to bacitracin (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O =
CC       undecaprenyl phosphate + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- MISCELLANEOUS: Bacitracin is thought to be involved in the
CC       inhibition of peptidoglycan synthesis by sequestering undecaprenyl
CC       diphosphate, thereby reducing the pool of lipid carrier available.
CC   -!- SIMILARITY: Belongs to the uppP family.
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DR   EMBL; CP000249; ABD13805.1; -; Genomic_DNA.
DR   RefSeq; YP_483534.1; -.
DR   GeneID; 3907435; -.
DR   GenomeReviews; CP000249_GR; Francci3_4459.
DR   KEGG; fra:Francci3_4459; -.
DR   HOGENOM; Q2J4I7; -.
DR   OMA; Q2J4I7; ILWSGVM.
DR   BioCyc; FSP106370:FRANCCI3_4459-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01006; -; 1.
DR   InterPro; IPR003824; Bacitracin-R_BacA.
DR   Pfam; PF02673; BacA; 1.
DR   TIGRFAMs; TIGR00753; undec_PP_bacA; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Hydrolase;
KW   Membrane; Peptidoglycan synthesis; Transmembrane.
FT   CHAIN         1    278       Undecaprenyl-diphosphatase 3.
FT                                /FTId=PRO_0000250237.
FT   TRANSMEM     42     62       Potential.
FT   TRANSMEM     88    108       Potential.
FT   TRANSMEM    119    139       Potential.
FT   TRANSMEM    187    207       Potential.
FT   TRANSMEM    224    244       Potential.
FT   TRANSMEM    254    274       Potential.
SQ   SEQUENCE   278 AA;  30056 MW;  8A8E6BC8687B2D73 CRC64;
     MNVLEAVFLG AVEGLTEFLP VSSTGHLTIL EKLLGHDIDD PDITAFTAII QVGAVFATLL
     YFRHDFRRLL AAWGRGVRDP AWREHPDYRF GWAVILGSIP IGLVGVAFKD QIETTLRSLW
     FVGGALILWS GVMGYADHVG TQKRHEEDVT WKDTLVIGIV QCMALIPGIS RSGATMSAGL
     LRGLDRVAVT RLSFFLSIPA LMAAAALQVL TKSDDIADGV GWPATIIATV VSFAVAYVAI
     AWLLKFIARH SYSVFIGYRL ALGATVLFLV ATGIVSAT
//