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Q2J4I7

- UPPP3_FRASC

UniProt

Q2J4I7 - UPPP3_FRASC

Protein

Undecaprenyl-diphosphatase 3

Gene

uppP3

Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciFSP106370:GI1F-4528-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 3UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 3UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 3UniRule annotation
    Gene namesi
    Name:uppP3UniRule annotation
    Ordered Locus Names:Francci3_4459
    OrganismiFrankia sp. (strain CcI3)
    Taxonomic identifieri106370 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
    ProteomesiUP000001937: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Undecaprenyl-diphosphatase 3PRO_0000250237Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi106370.Francci3_4459.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei88 – 10821HelicalUniRule annotationAdd
    BLAST
    Transmembranei119 – 13921HelicalUniRule annotationAdd
    BLAST
    Transmembranei187 – 20721HelicalUniRule annotationAdd
    BLAST
    Transmembranei224 – 24421HelicalUniRule annotationAdd
    BLAST
    Transmembranei254 – 27421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiPIVFDIY.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2J4I7-1 [UniParc]FASTAAdd to Basket

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    MNVLEAVFLG AVEGLTEFLP VSSTGHLTIL EKLLGHDIDD PDITAFTAII    50
    QVGAVFATLL YFRHDFRRLL AAWGRGVRDP AWREHPDYRF GWAVILGSIP 100
    IGLVGVAFKD QIETTLRSLW FVGGALILWS GVMGYADHVG TQKRHEEDVT 150
    WKDTLVIGIV QCMALIPGIS RSGATMSAGL LRGLDRVAVT RLSFFLSIPA 200
    LMAAAALQVL TKSDDIADGV GWPATIIATV VSFAVAYVAI AWLLKFIARH 250
    SYSVFIGYRL ALGATVLFLV ATGIVSAT 278
    Length:278
    Mass (Da):30,056
    Last modified:March 7, 2006 - v1
    Checksum:i8A8E6BC8687B2D73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD13805.1.
    RefSeqiWP_011438813.1. NC_007777.1.
    YP_483534.1. NC_007777.1.

    Genome annotation databases

    EnsemblBacteriaiABD13805; ABD13805; Francci3_4459.
    GeneIDi3907435.
    KEGGifra:Francci3_4459.
    PATRICi21932533. VBIFraSp10456_4859.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000249 Genomic DNA. Translation: ABD13805.1 .
    RefSeqi WP_011438813.1. NC_007777.1.
    YP_483534.1. NC_007777.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 106370.Francci3_4459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD13805 ; ABD13805 ; Francci3_4459 .
    GeneIDi 3907435.
    KEGGi fra:Francci3_4459.
    PATRICi 21932533. VBIFraSp10456_4859.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi PIVFDIY.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci FSP106370:GI1F-4528-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CcI3.

    Entry informationi

    Entry nameiUPPP3_FRASC
    AccessioniPrimary (citable) accession number: Q2J4I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3