Reviewed, UniProtKB/Swiss-Prot Q2J4I7 (UPPP3_FRASC)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 3
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 3
    Bacitracin resistance protein 3

Gene names

Name:	uppP3
Ordered Locus Names:	Francci3_4459

Organism

Frankia sp. (strain CcI3) [Complete proteome] [HAMAP]

Taxonomic identifier

106370 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Undecaprenyl-diphosphatase 3 HAMAP MF_01006		PRO_0000250237
Regions
	Transmembrane	42 – 62	21	Potential
	Transmembrane	88 – 108	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	187 – 207	21	Potential
	Transmembrane	224 – 244	21	Potential
	Transmembrane	254 – 274	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2J4I7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 8A8E6BC8687B2D73	FASTA	278	30,056
	10 20 30 40 50 60 MNVLEAVFLG AVEGLTEFLP VSSTGHLTIL EKLLGHDIDD PDITAFTAII QVGAVFATLL 70 80 90 100 110 120 YFRHDFRRLL AAWGRGVRDP AWREHPDYRF GWAVILGSIP IGLVGVAFKD QIETTLRSLW 130 140 150 160 170 180 FVGGALILWS GVMGYADHVG TQKRHEEDVT WKDTLVIGIV QCMALIPGIS RSGATMSAGL 190 200 210 220 230 240 LRGLDRVAVT RLSFFLSIPA LMAAAALQVL TKSDDIADGV GWPATIIATV VSFAVAYVAI 250 260 270 AWLLKFIARH SYSVFIGYRL ALGATVLFLV ATGIVSAT

References

[1]

"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography." Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y. , Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R. Genome Res. 17:7-15(2007) [PubMed: 17151343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000249 Genomic DNA. Translation: ABD13805.1.
RefSeq	YP_483534.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2J4I7.
Genome annotation databases
GeneID	3907435.
GenomeReviews	Gene locus Francci3_4459 in contig CP000249_GR.
KEGG	fra:Francci3_4459.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	ILWSGVM.
PhylomeDB	Q2J4I7.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP3_FRASC

Accession

Primary (citable) accession number: Q2J4I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	March 7, 2006
Last modified:	February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)