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Q2J4I7

- UPPP3_FRASC

UniProt

Q2J4I7 - UPPP3_FRASC

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Protein

Undecaprenyl-diphosphatase 3

Gene
uppP3, Francci3_4459
Organism
Frankia sp. (strain CcI3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciFSP106370:GI1F-4528-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 3 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 3
Undecaprenyl pyrophosphate phosphatase 3
Gene namesi
Name:uppP3
Ordered Locus Names:Francci3_4459
OrganismiFrankia sp. (strain CcI3)
Taxonomic identifieri106370 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia
ProteomesiUP000001937: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Reviewed predictionAdd
BLAST
Transmembranei88 – 10821Helical; Reviewed predictionAdd
BLAST
Transmembranei119 – 13921Helical; Reviewed predictionAdd
BLAST
Transmembranei187 – 20721Helical; Reviewed predictionAdd
BLAST
Transmembranei224 – 24421Helical; Reviewed predictionAdd
BLAST
Transmembranei254 – 27421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Undecaprenyl-diphosphatase 3UniRule annotationPRO_0000250237Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi106370.Francci3_4459.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiPIVFDIY.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2J4I7-1 [UniParc]FASTAAdd to Basket

« Hide

MNVLEAVFLG AVEGLTEFLP VSSTGHLTIL EKLLGHDIDD PDITAFTAII    50
QVGAVFATLL YFRHDFRRLL AAWGRGVRDP AWREHPDYRF GWAVILGSIP 100
IGLVGVAFKD QIETTLRSLW FVGGALILWS GVMGYADHVG TQKRHEEDVT 150
WKDTLVIGIV QCMALIPGIS RSGATMSAGL LRGLDRVAVT RLSFFLSIPA 200
LMAAAALQVL TKSDDIADGV GWPATIIATV VSFAVAYVAI AWLLKFIARH 250
SYSVFIGYRL ALGATVLFLV ATGIVSAT 278
Length:278
Mass (Da):30,056
Last modified:March 7, 2006 - v1
Checksum:i8A8E6BC8687B2D73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD13805.1.
RefSeqiWP_011438813.1. NC_007777.1.
YP_483534.1. NC_007777.1.

Genome annotation databases

EnsemblBacteriaiABD13805; ABD13805; Francci3_4459.
GeneIDi3907435.
KEGGifra:Francci3_4459.
PATRICi21932533. VBIFraSp10456_4859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000249 Genomic DNA. Translation: ABD13805.1 .
RefSeqi WP_011438813.1. NC_007777.1.
YP_483534.1. NC_007777.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 106370.Francci3_4459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD13805 ; ABD13805 ; Francci3_4459 .
GeneIDi 3907435.
KEGGi fra:Francci3_4459.
PATRICi 21932533. VBIFraSp10456_4859.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi PIVFDIY.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci FSP106370:GI1F-4528-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CcI3.

Entry informationi

Entry nameiUPPP3_FRASC
AccessioniPrimary (citable) accession number: Q2J4I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi