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Q2J4D1 (ILVD_FRASC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:Francci3_4515
OrganismFrankia sp. (strain CcI3) [Complete proteome] [HAMAP]
Taxonomic identifier106370 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length617 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 617617Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_1000000983

Sites

Metal binding1221Iron-sulfur (4Fe-4S) Potential
Metal binding1971Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q2J4D1 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: BF5BE4FD129C595C

FASTA61764,329
        10         20         30         40         50         60 
MPALRSRTTT HGRNMAGARA LWRATGMTDD DFGKPIVAVA NSFTEFVPGH VHLRNLGSLV 

        70         80         90        100        110        120 
AGAVAEAGGV AREFNTIAVD DGIAMGHGGM LYSLPSRELI ADSVEYMVNA HCADALVCIS 

       130        140        150        160        170        180 
NCDKITPGML LAALRLNIPT VFVSGGAMES GNAVISGGTA RSRLDLITAM SAAVNPDVSD 

       190        200        210        220        230        240 
GDLSTIERSA CPTCGSCSGM FTANSMNCLT EAIGLSLPGN GSTLATAAAR RELFVEAGRL 

       250        260        270        280        290        300 
VVDLARRYYE KDDEAVLPRS IATAAAFRNA FAVDVAMGGS TNTVLHLLAA AVEAGVDVTL 

       310        320        330        340        350        360 
ADIDQISRTV PCLCKVAPSS TRYYMEDVHR AGGIPAILGE LDRAGLLDPD PHTVHSASLR 

       370        380        390        400        410        420 
EFLDRWDVRG PSPSPDAIEL FHAAPGGVRT IEPFSSTNRW DTLDTDARDG CIRSVEHAYS 

       430        440        450        460        470        480 
AEGGLAVLFG NLAVEGAVVK TAGVDEGQWT FRGPALVVES QEEAVDAILT GRVKAGNVII 

       490        500        510        520        530        540 
VRYEGPRGGP GMQEMLYPTA FLKGRGLGPK CALITDGRFS GGSSGLSIGH VSPEAAHGGT 

       550        560        570        580        590        600 
IALVRDGDII EIDIPARRLE LVVSDEELAS RRAALEAAGG YRPTGRERPV SMALRAYAAM 

       610 
ATSASTGAAR DVGLLGG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000249 Genomic DNA. Translation: ABD13861.1.
RefSeqYP_483590.1. NC_007777.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2J4D1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3907492.
GenomeReviewsGene locus Francci3_4515 in contig CP000249_GR.
KEGGfra:Francci3_4515.
PATRIC21932651. VBIFraSp10456_4917.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0129.
HOGENOMHBG671001.
OMASQDCRWP.
PhylomeDBQ2J4D1.
ProtClustDBPRK12448.

Enzyme and pathway databases

BioCycFSP106370:FRANCCI3_4515-MONOMER.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_FRASC
AccessionPrimary (citable) accession number: Q2J4D1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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