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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei47S-adenosyl-L-methionineUniRule annotation1
Binding sitei78S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei99S-adenosyl-L-methionineUniRule annotation1
Binding sitei141S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-78-MONOMER
UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:RPB_0079
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002417291 – 253Ubiquinone biosynthesis O-methyltransferaseAdd BLAST253

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_0079

Structurei

3D structure databases

ProteinModelPortaliQ2J419
SMRiQ2J419
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HWB Bacteria
COG2227 LUCA
HOGENOMiHOG000278064
KOiK00568
OMAiGTHDWEK
OrthoDBiPOG091H064Z

Family and domain databases

HAMAPiMF_00472 UbiG, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR010233 UbiG_MeTrfase
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01983 UbiG, 1 hit

Sequencei

Sequence statusi: Complete.

Q2J419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQSESPGP VSPSVDPAEI AKFSKLSAQW WDPTGKMAPL HRINPLRISF
60 70 80 90 100
IRDAACRKFE RNAKSLSCLS GLRMLDIGCG AGLLCEPFTR LGAQVIGIDP
110 120 130 140 150
SATNIAAAKI HADKSHLPID YRCTTVEEID PRERFDIVLA MEVIEHVTDV
160 170 180 190 200
GAFLGRCAAL MKPNGIMVVA TLNRNWKSFA LAIVGAEYVM RWLPRGTHQW
210 220 230 240 250
DKFVTPAELE QHLHGFGMIV TEQSGLVFNP LADRWKLSAD MDVNYMVVAE

TAP
Length:253
Mass (Da):27,913
Last modified:March 7, 2006 - v1
Checksum:i976A18EE297EC7A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD04791.1
RefSeqiWP_011438981.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD04791; ABD04791; RPB_0079
KEGGirpb:RPB_0079

Similar proteinsi

Entry informationi

Entry nameiUBIG_RHOP2
AccessioniPrimary (citable) accession number: Q2J419
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health