Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine(37) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei113S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-352-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
Alternative name(s):
M1G-methyltransferaseUniRule annotation
tRNA [GM37] methyltransferaseUniRule annotation
Gene namesi
Name:trmDUniRule annotation
Ordered Locus Names:RPB_0350
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002574611 – 252tRNA (guanine-N(1)-)-methyltransferaseAdd BLAST252

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi316058.RPB_0350

Structurei

3D structure databases

ProteinModelPortaliQ2J399
SMRiQ2J399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 138S-adenosyl-L-methionine bindingUniRule annotation6

Sequence similaritiesi

Belongs to the RNA methyltransferase TrmD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D6X Bacteria
COG0336 LUCA
HOGENOMiHOG000016242
KOiK00554
OMAiILCGHYK
OrthoDBiPOG091H01WE

Family and domain databases

Gene3Di1.10.1270.20, 1 hit
3.40.1280.10, 1 hit
HAMAPiMF_00605 TrmD, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR002649 tRNA_m1G_MeTrfase_bac
IPR023148 tRNA_m1G_MeTrfase_C
IPR029026 tRNA_m1G_MTases_N
IPR016009 tRNA_MeTrfase_TRMD/TRM10
PANTHERiPTHR32125:SF1 PTHR32125:SF1, 1 hit
PfamiView protein in Pfam
PF01746 tRNA_m1G_MT, 1 hit
PIRSFiPIRSF000386 tRNA_mtase, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit
TIGRFAMsiTIGR00088 trmD, 1 hit

Sequencei

Sequence statusi: Complete.

Q2J399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWRATVLTL FPEMFPGPLG VSLAGRGLAA GLWALEARDI RDSATDRHRS
60 70 80 90 100
VDDTPAGGGP GMVLRADVLA AAIDAADPVP GRPRLVMSPR GRPLTQARVA
110 120 130 140 150
ELAAGPGPLI VCGRFEGIDQ RVIDARNLEE VSIGDYVLSG GEIAALALID
160 170 180 190 200
ACVRLLPGVM GKLDSSAEES FSAGLLEYPQ YTRPKSFEGR PIPEILTSGD
210 220 230 240 250
HAKVAAWRQA EAEALTRARR PDLWAARSVA RPAANAPAKG ESQKTPKNKT

DG
Length:252
Mass (Da):26,647
Last modified:March 7, 2006 - v1
Checksum:i59B90EBBB8FF993D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD05061.1
RefSeqiWP_011439251.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD05061; ABD05061; RPB_0350
KEGGirpb:RPB_0350

Similar proteinsi

Entry informationi

Entry nameiTRMD_RHOP2
AccessioniPrimary (citable) accession number: Q2J399
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health