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Q2J390

- DAPF_RHOP2

UniProt

Q2J390 - DAPF_RHOP2

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Protein
Diaminopimelate epimerase
Gene
dapF, RPB_0359
Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171Substrate By similarity
Binding sitei47 – 471Substrate By similarity
Binding sitei67 – 671Substrate By similarity
Active sitei76 – 761Proton donor/acceptor By similarity
Binding sitei164 – 1641Substrate By similarity
Sitei166 – 1661Important for catalytic activity By similarity
Binding sitei197 – 1971Substrate By similarity
Sitei215 – 2151Important for catalytic activity By similarity
Active sitei224 – 2241Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciRPAL316058:GHF1-365-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:RPB_0359
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000008809: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Diaminopimelate epimeraseUniRule annotation
PRO_1000011946Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 224UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_0359.

Structurei

3D structure databases

ProteinModelPortaliQ2J390.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 152Substrate binding By similarity
Regioni76 – 783Substrate binding By similarity
Regioni215 – 2162Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiKMRIFNN.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2J390-1 [UniParc]FASTAAdd to Basket

« Hide

MSALDNRLFA KMNGIGNEIV VVDLRDQPAP VTPDDARAVA AHVPYDQLML    50
LQPARLPGTE AFVRIYNNDG SESGACGNGM RCVARQLFAG SDQQGLTFET 100
RAGLLNCWRG PAEGLFTVDM GAPKFGWQDI PLAEEFRDTR GIELQIGPID 150
APILHTPSVV SMGNPHAIFW VDDIHAYDLG QFGPLLENHP IFPERANITL 200
AHIVDRQHIT MRTWERGAGL TRACGSAACA TAVAAARLRR TDRIVEMTLP 250
GGKLTIEWRE GDDHVLMTGG AELEFEGRFD PALFVGACDT TAA 293
Length:293
Mass (Da):31,861
Last modified:March 7, 2006 - v1
Checksum:iAEB7454D530C9A54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD05070.1.
RefSeqiYP_483981.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD05070; ABD05070; RPB_0359.
GeneIDi3908625.
KEGGirpb:RPB_0359.
PATRICi23295149. VBIRhoPal125544_0378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD05070.1 .
RefSeqi YP_483981.1. NC_007778.1.

3D structure databases

ProteinModelPortali Q2J390.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316058.RPB_0359.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD05070 ; ABD05070 ; RPB_0359 .
GeneIDi 3908625.
KEGGi rpb:RPB_0359.
PATRICi 23295149. VBIRhoPal125544_0378.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi KMRIFNN.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci RPAL316058:GHF1-365-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HaA2.

Entry informationi

Entry nameiDAPF_RHOP2
AccessioniPrimary (citable) accession number: Q2J390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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