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Q2J364

- SYL_RHOP2

UniProt

Q2J364 - SYL_RHOP2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei633 – 6331ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRPAL316058:GHF1-391-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RPB_0385
    OrganismiRhodopseudomonas palustris (strain HaA2)
    Taxonomic identifieri316058 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000008809: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 874874Leucine--tRNA ligasePRO_1000009409Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316058.RPB_0385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2J364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi630 – 6345"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2J364-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNERYNARE SEPKWQAKWD EAKIFATRND DPRPKYYVLE MFPYPSGRIH    50
    MGHVRNYTMG DVVARTMRAR GHNVLHPMGW DAFGLPAENA AIERKVAPKA 100
    WTYDNIASMK KQLQTMGLSL DWAREFATCD PTYYKHQQKM FLDFLKVGLA 150
    ERETRKLNWD PVDMTVLANE QVIDGRGWRS GAVVEQREMN QWVFKITRYA 200
    QDLLDALETL DRWPDKVRLM QRNWIGRSEG LLVRFALDAA TTPAGETELK 250
    IFTTRPDTLF GAKFMAIAPD HPLAQAAAAK NEKIAAFVEE CKKRGTAQAE 300
    IDTAEKQGID TGIRALHPFD PTWQIPVYVA NFVLMEYGTG AIFGCPAHDQ 350
    RDLDFVNKYQ LGNTPVVCPE GQDPLSFVIT DEAYDGDGRL INSRFLDGMS 400
    IADAKEEVAK RLETATLGNA PVGERKVNFR LRDWGISRQR YWGCPIPVIH 450
    CEVCGVVPVP DKDLPVVLPE DVSFDKPGNA LDHHPTWKHV PCPQCGGKAQ 500
    RETDTMDTFV DSSWYFARFT DPWNETAPTT PDVVNRMLPV DQYIGGVEHA 550
    ILHLLYSRFF TRAMKATGHL GLDEPFRGMF TQGMVVHETY RTADGHFASP 600
    AEVAIVAEGD GRRATLLDGG TPVEIGPIEK MSKSKRNTVD PDDIIGSYGA 650
    DTARWFMLSD SPPDRDVIWS EEGVKGASRF VQRLWRMVND AAAIARSAPA 700
    ERPATFGPEA LAVRKAAHGA LDKVLSGIER LAFNVSLAHI REFANSFGEA 750
    LAKPGQPSPD LAWAIREAAV ILVQLFHPMM PHLAEECWAA LGRPGLVSEA 800
    LWPQIERDLL VEDSITLPVQ VNGKKRGDIT VARDANTQEI EAAVLALDAV 850
    RQALDGKPVR KVIVVPQRIV NVVG 874
    Length:874
    Mass (Da):97,628
    Last modified:March 7, 2006 - v1
    Checksum:iC5CB05782C840BC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000250 Genomic DNA. Translation: ABD05096.1.
    RefSeqiYP_484007.1. NC_007778.1.

    Genome annotation databases

    EnsemblBacteriaiABD05096; ABD05096; RPB_0385.
    GeneIDi3908823.
    KEGGirpb:RPB_0385.
    PATRICi23295203. VBIRhoPal125544_0405.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000250 Genomic DNA. Translation: ABD05096.1 .
    RefSeqi YP_484007.1. NC_007778.1.

    3D structure databases

    ProteinModelPortali Q2J364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316058.RPB_0385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD05096 ; ABD05096 ; RPB_0385 .
    GeneIDi 3908823.
    KEGGi rpb:RPB_0385.
    PATRICi 23295203. VBIRhoPal125544_0405.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RPAL316058:GHF1-391-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HaA2.

    Entry informationi

    Entry nameiSYL_RHOP2
    AccessioniPrimary (citable) accession number: Q2J364
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3