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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei633ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-389-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RPB_0385
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094091 – 874Leucine--tRNA ligaseAdd BLAST874

Proteomic databases

PRIDEiQ2J364

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_0385

Structurei

3D structure databases

ProteinModelPortaliQ2J364
SMRiQ2J364
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi630 – 634"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q2J364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNERYNARE SEPKWQAKWD EAKIFATRND DPRPKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYTMG DVVARTMRAR GHNVLHPMGW DAFGLPAENA AIERKVAPKA
110 120 130 140 150
WTYDNIASMK KQLQTMGLSL DWAREFATCD PTYYKHQQKM FLDFLKVGLA
160 170 180 190 200
ERETRKLNWD PVDMTVLANE QVIDGRGWRS GAVVEQREMN QWVFKITRYA
210 220 230 240 250
QDLLDALETL DRWPDKVRLM QRNWIGRSEG LLVRFALDAA TTPAGETELK
260 270 280 290 300
IFTTRPDTLF GAKFMAIAPD HPLAQAAAAK NEKIAAFVEE CKKRGTAQAE
310 320 330 340 350
IDTAEKQGID TGIRALHPFD PTWQIPVYVA NFVLMEYGTG AIFGCPAHDQ
360 370 380 390 400
RDLDFVNKYQ LGNTPVVCPE GQDPLSFVIT DEAYDGDGRL INSRFLDGMS
410 420 430 440 450
IADAKEEVAK RLETATLGNA PVGERKVNFR LRDWGISRQR YWGCPIPVIH
460 470 480 490 500
CEVCGVVPVP DKDLPVVLPE DVSFDKPGNA LDHHPTWKHV PCPQCGGKAQ
510 520 530 540 550
RETDTMDTFV DSSWYFARFT DPWNETAPTT PDVVNRMLPV DQYIGGVEHA
560 570 580 590 600
ILHLLYSRFF TRAMKATGHL GLDEPFRGMF TQGMVVHETY RTADGHFASP
610 620 630 640 650
AEVAIVAEGD GRRATLLDGG TPVEIGPIEK MSKSKRNTVD PDDIIGSYGA
660 670 680 690 700
DTARWFMLSD SPPDRDVIWS EEGVKGASRF VQRLWRMVND AAAIARSAPA
710 720 730 740 750
ERPATFGPEA LAVRKAAHGA LDKVLSGIER LAFNVSLAHI REFANSFGEA
760 770 780 790 800
LAKPGQPSPD LAWAIREAAV ILVQLFHPMM PHLAEECWAA LGRPGLVSEA
810 820 830 840 850
LWPQIERDLL VEDSITLPVQ VNGKKRGDIT VARDANTQEI EAAVLALDAV
860 870
RQALDGKPVR KVIVVPQRIV NVVG
Length:874
Mass (Da):97,628
Last modified:March 7, 2006 - v1
Checksum:iC5CB05782C840BC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD05096.1
RefSeqiWP_011439286.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD05096; ABD05096; RPB_0385
KEGGirpb:RPB_0385

Similar proteinsi

Entry informationi

Entry nameiSYL_RHOP2
AccessioniPrimary (citable) accession number: Q2J364
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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