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Q2J364

- SYL_RHOP2

UniProt

Q2J364 - SYL_RHOP2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL316058:GHF1-391-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RPB_0385
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000008809: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Leucine--tRNA ligasePRO_1000009409Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_0385.

Structurei

3D structure databases

ProteinModelPortaliQ2J364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi630 – 6345"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2J364-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNERYNARE SEPKWQAKWD EAKIFATRND DPRPKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYTMG DVVARTMRAR GHNVLHPMGW DAFGLPAENA AIERKVAPKA
110 120 130 140 150
WTYDNIASMK KQLQTMGLSL DWAREFATCD PTYYKHQQKM FLDFLKVGLA
160 170 180 190 200
ERETRKLNWD PVDMTVLANE QVIDGRGWRS GAVVEQREMN QWVFKITRYA
210 220 230 240 250
QDLLDALETL DRWPDKVRLM QRNWIGRSEG LLVRFALDAA TTPAGETELK
260 270 280 290 300
IFTTRPDTLF GAKFMAIAPD HPLAQAAAAK NEKIAAFVEE CKKRGTAQAE
310 320 330 340 350
IDTAEKQGID TGIRALHPFD PTWQIPVYVA NFVLMEYGTG AIFGCPAHDQ
360 370 380 390 400
RDLDFVNKYQ LGNTPVVCPE GQDPLSFVIT DEAYDGDGRL INSRFLDGMS
410 420 430 440 450
IADAKEEVAK RLETATLGNA PVGERKVNFR LRDWGISRQR YWGCPIPVIH
460 470 480 490 500
CEVCGVVPVP DKDLPVVLPE DVSFDKPGNA LDHHPTWKHV PCPQCGGKAQ
510 520 530 540 550
RETDTMDTFV DSSWYFARFT DPWNETAPTT PDVVNRMLPV DQYIGGVEHA
560 570 580 590 600
ILHLLYSRFF TRAMKATGHL GLDEPFRGMF TQGMVVHETY RTADGHFASP
610 620 630 640 650
AEVAIVAEGD GRRATLLDGG TPVEIGPIEK MSKSKRNTVD PDDIIGSYGA
660 670 680 690 700
DTARWFMLSD SPPDRDVIWS EEGVKGASRF VQRLWRMVND AAAIARSAPA
710 720 730 740 750
ERPATFGPEA LAVRKAAHGA LDKVLSGIER LAFNVSLAHI REFANSFGEA
760 770 780 790 800
LAKPGQPSPD LAWAIREAAV ILVQLFHPMM PHLAEECWAA LGRPGLVSEA
810 820 830 840 850
LWPQIERDLL VEDSITLPVQ VNGKKRGDIT VARDANTQEI EAAVLALDAV
860 870
RQALDGKPVR KVIVVPQRIV NVVG
Length:874
Mass (Da):97,628
Last modified:March 7, 2006 - v1
Checksum:iC5CB05782C840BC2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD05096.1.
RefSeqiYP_484007.1. NC_007778.1.

Genome annotation databases

EnsemblBacteriaiABD05096; ABD05096; RPB_0385.
GeneIDi3908823.
KEGGirpb:RPB_0385.
PATRICi23295203. VBIRhoPal125544_0405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000250 Genomic DNA. Translation: ABD05096.1 .
RefSeqi YP_484007.1. NC_007778.1.

3D structure databases

ProteinModelPortali Q2J364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316058.RPB_0385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD05096 ; ABD05096 ; RPB_0385 .
GeneIDi 3908823.
KEGGi rpb:RPB_0385.
PATRICi 23295203. VBIRhoPal125544_0405.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RPAL316058:GHF1-391-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HaA2.

Entry informationi

Entry nameiSYL_RHOP2
AccessioniPrimary (citable) accession number: Q2J364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3