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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85S-adenosyl-L-methionineUniRule annotation1
Binding sitei110S-adenosyl-L-methionineUniRule annotation1
Binding sitei137S-adenosyl-L-methionineUniRule annotation1
Active sitei159By similarity1
Binding sitei159S-adenosyl-L-methionineUniRule annotation1
Binding sitei163SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:RPB_0596
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002882161 – 256tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST256

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_0596

Structurei

3D structure databases

ProteinModelPortaliQ2J2K3
SMRiQ2J2K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000073969
KOiK03439
OMAiPDPWHKS
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q2J2K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTIDRRVQP IAHLACNHQR AFIDMNESVH HQGSFFGRRK GHKLRAHQAD
60 70 80 90 100
LVDKLLPHLA LAIDGPAPAS LVELFDPPVE AVRLEIGFGG GEHLIAEALA
110 120 130 140 150
HPSTGFIGAE PYVNGMAKIL ARIEQENIRN IRLFAGDAAA LMAWVPAHDL
160 170 180 190 200
NRIDLIHPDP WPKRRHWKRR FVQDAMVGAM ARALRANGEF RFVSDIDSYN
210 220 230 240 250
AWTLAHLLRA PDFDWTAERA DDWRKPWPNY TMTRYGRKAE REGRRAAYLR

FRRRAA
Length:256
Mass (Da):29,241
Last modified:March 7, 2006 - v1
Checksum:iE5909A66946C4D53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD05307.1

Genome annotation databases

EnsemblBacteriaiABD05307; ABD05307; RPB_0596
KEGGirpb:RPB_0596

Similar proteinsi

Entry informationi

Entry nameiTRMB_RHOP2
AccessioniPrimary (citable) accession number: Q2J2K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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