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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Rhodopseudomonas palustris (strain HaA2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi487MagnesiumUniRule annotation1
Metal bindingi493MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciRPAL316058:G1G5V-612-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:RPB_0605
OrganismiRhodopseudomonas palustris (strain HaA2)
Taxonomic identifieri316058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000008809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003298131 – 718Polyribonucleotide nucleotidyltransferaseAdd BLAST718

Interactioni

Protein-protein interaction databases

STRINGi316058.RPB_0605

Structurei

3D structure databases

ProteinModelPortaliQ2J2J4
SMRiQ2J2J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini554 – 613KHUniRule annotationAdd BLAST60
Domaini623 – 691S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218327
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 1 hit
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q2J2J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNKHSVEID WGGRPLKLET GKVARQADGA VVATYGETIV LATVVAAKTP
60 70 80 90 100
REGVDFLPLT VDYQEKTYAA GRIPGGYFKR EGRPTEKETL VSRLIDRPIR
110 120 130 140 150
PLFADGWRNE TQVIVTVLSH DMENDPDILA MVAASAALTL SGAPFKGPIG
160 170 180 190 200
AARVGFINDE YVLNPVLDEM PETQLELVVA GTADAVLMVE SEAKELSEEI
210 220 230 240 250
MLGAVMFGHR HFQPVIDAII ELAEKAAKEP RELVVIDDSA IEKEMLGLVE
260 270 280 290 300
QELRAAYAIP VKQERYAAVG KVKEKAIAHF FPEGEEPKYD KLRIAGVFKE
310 320 330 340 350
LEAKIVRWNI LDTGKRIDGR DSKTVRSIIA EAGVLPRAHG SALFTRGETQ
360 370 380 390 400
ALVVTTLGTG EDEQYVDSLA GTYKETFLLH YNFPPYSVGE TGRLGGTKRR
410 420 430 440 450
EIGHGKLAWR AIRPVLPPHH EFPYTIRVVS EITESNGSSS MASVCGASLA
460 470 480 490 500
LMDAGVPLKR PTAGIAMGLI LEGERFAVLS DILGDEDHLG DMDFKVAGTE
510 520 530 540 550
QGITSLQMDI KIAGITEEIM KVALGQAKDG RIHILGEMSK ALDRARAELG
560 570 580 590 600
EHAPRIETFK IPTDKIREVI GTGGKVIREI VEKTGAKVNI EDDGTVKVAS
610 620 630 640 650
SDGESIKAAI KWIKSIASDP EVGEIYEGTV VKVMEFGAFV NFFGAKDGLV
660 670 680 690 700
HISQLASGRV QKTSDVVKEG DKVKVKLLGF DDRGKTRLSM RVVDQETGED
710
LEAKQKAEGE APAQATGE
Length:718
Mass (Da):78,029
Last modified:March 7, 2006 - v1
Checksum:iD6297DD775038D2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000250 Genomic DNA Translation: ABD05316.1
RefSeqiWP_011439506.1, NC_007778.1

Genome annotation databases

EnsemblBacteriaiABD05316; ABD05316; RPB_0605
KEGGirpb:RPB_0605

Similar proteinsi

Entry informationi

Entry nameiPNP_RHOP2
AccessioniPrimary (citable) accession number: Q2J2J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 7, 2006
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health